Epstein Barr Virus (EBV) is associated with malignancies of lymphoid and epithelial origin. While the precise role of EBV in oncogenesis remains elusive, latent membrane protein 2A (LMP2A) is detected in all EBV-associated malignancies, implicating LMP2A in their pathogenesis. Interestingly, LMP2A is expressed in EBV-associated malignancies such as Burkitt's Lymphoma,...
Chapter one investigates the impact of agents' expectations about future fundamental economic disturbances (news) on macroeconomic dynamics. Several intuitive tests provide insight into the information content of the yield curve and its' ability to identify these 'news' disturbances. Bayesian estimation of a dynamic stochastic general equilibrium (DSGE) model using conventional...
Tonia René Holverson The HPV genome contains a bipartite promoter system that regulates the expression of early and late gene transcripts. The early proteins include the replication proteins E1 and E2, the oncoproteins E6 and E7, and the late functioning proteins E4 and E5. The late proteins include the capsid...
Estrogens are traditionally thought to act through a nuclear receptor-mediated mechanism to regulate gene transcription in target tissues. The hippocampus has been shown to be sensitive to estrogen; estrogen regulates GABAergic inhibition and spine density of dorsal CA1 pyramidal cells. However, very few neurons expressing nuclear estrogen receptors (ERs) have...
The kinetoplastid protozoan <em>Trypanosoma brucei</em> is the causative agent of African trypanosomiasis, affecting humans, and Nagana disease, affecting cattle, prevalent in regions of sub-Saharan Africa. Our lab demonstrated that the flagellum of <em>T. brucei</em> is enriched in lipid rafts, membrane areas composed of sphingolipids, sterols, and proteins that serve as...
This dissertation explores the factors that influence the creation and interpretation of novel denominal verbs in English. Of particular focus is the potential influence of one factor, termed here the Semantic Category Distribution Effect. The Semantic Category Distribution Effect involves the type frequency distribution of existing forms of a given...
The last two decades in nineteenth-century West Africa witnessed a two-fold movement, namely the territorial expansion of French colonial empire and the first attempts to extend biomedicine through mass vaccination to control smallpox epidemics. This study provides both a deep history and conceptual framework to analyze the relationship between the...
This study examined the effects of swallow task on swallow physiology, respiratory phase relationships, and oxygen saturation in healthy adult males. This study hoped to provide a building block to clinically relevant research with individuals with compromised swallowing and respiration. Subjects included 40 healthy adult males with no history of...
High-performance scientific computing in a modern age uses parallel techniques at a scale of hundreds of thousands of processors. These large-scale applications have I/O system workloads that are primarily driven by small, sparse I/O operations. While parallel file systems have provided application developers with scalable peak I/O bandwidth for large,...
This dissertation explores a seventy-year period of community growth and activism among African Americans in nineteenth-century Iowa, showing how citizenship was defined, contested, expanded and confined. Antebellum black migrants lived on the margins of a hostile society and struggled for equal citizenship using their labor, their community institutions, the legal...