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Replication Data For: Ratiometric sensing of Pnt and Yan transcription factor levels confers ultrasensitivity to photoreceptor fate transitions in Drosophila

Description:

Cell state transitions are often triggered by large changes in the concentrations of transcription factors and therefore large differences in their stoichiometric ratios. Whether cells can elicit transitions using modest changes in the ratios of co-expressed factors is unclear. Here, we investigate how cells in the Drosophila eye resolve state...

Creator:

Carthew Lab, Amaral Lab, and Rebay Lab

Owner:

Sebastian Bernasek

Publisher:

Northwestern University

Date Uploaded:

04/06/2023

Date Modified:

04/06/2023

Date Created:

04/06/23

Resource Type:

Dataset
Replication Data for: Repressive gene regulation synchronizes development with cellular metabolism

Description:

Metabolic conditions affect the developmental tempo of most animal species. Consequently, developmental gene regulatory networks (GRNs) must faithfully adjust their dynamics to a variable time scale. We find evidence that weak repressors of gene expression provide the necessary coupling between GRN output and cellular metabolism. Using a mathematical model that...

Keyword:

Development, Gene Regulation , Gene Expression, and Metabolism

Subject:

Developmental Biology

Creator:

Bagheri Lab, Carthew Lab, and Amaral Lab

Owner:

Sebastian Bernasek

Language:

English

Date Uploaded:

01/24/2019

Date Modified:

11/03/2020

Date Created:

2019-01-24

Resource Type:

Dataset

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Replication Data For: Ratiometric sensing of Pnt and Yan transcription factor levels confers ultrasensitivity to photoreceptor fate transitions in Drosophila

Replication Data for: Repressive gene regulation synchronizes development with cellular metabolism

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