Histamine is a well-known potent mediator during the elicitation of IgE-mediated allergic diseases. The most robust, and potentially fatal, response of histamine is observed in patients with food allergy that undergo IgE-mediated anaphylaxis. The key mechanisms of the biology of histamine in allergic disease are well-established, however there are still...
Problems in interpersonal functioning are a major concern. In adults, interpersonal dysfunction is often investigated as it relates to personality disorders (PDs). In fact, researchers have argued that a core of interpersonal dysfunction is what defines personality disorders (Hopwood, Wright, Ansell, & Pincus, 2013). This is perhaps most evident for...
This dissertation explains the heterogeneous effects of armed conflict on sub-national governance in the North Caucasus. While acknowledging the role of inherited institutions, my multimethod investigation shows how they were strategically transformed during the breakup of the Soviet Union, creating unintended consequences and the basis for governance today. My main...
Nonlinear systems with many interacting components often exhibit behaviors that cannot be anticipated, even in principle, by only knowing the properties of the constituent parts and thereby emerge as a result of interactions between the parts. Examples of such systems range from power grids and financial markets to food networks...
The literature has established glucokinase (GCK) to be the principal hexokinase (HK) in the liver, operating as a glucose sensor to regulate glucose metabolism and lipid homeostasis. We have recently proposed Hexokinase Domain Containing-1 (HKDC1) to be a novel 5th HK with expression in the liver. Here, we reveal HKDC1...
Identifying key molecular mechanisms and targets for therapeutic development in sporadic neurodegenerative diseases has been challenging. Therefore, in-depth investigation of genetic forms of disease can provide valuable insight into pathogenic disease mechanisms. The discovery of genetic forms of Parkinson’s disease (PD) has highlighted the importance of the autophagy/lysosomal and mitochondrial/oxidative...
Public memory studies in rhetoric have typically neglected how we use shared memories to form, maintain, and pass down social norms through the objects we encounter and the practices we participate in during our everyday lives. This is especially true for children’s toys, because they are understood as essential objects...
Recent studies have begun to examine white matter connectivity aberrations in psychiatric populations, such as major depressive disorder. Several studies have found reduced white matter integrity (WMI) in depressed samples, though the location of this reduction is not clear. Incorporating symptom measures of depression severity and rumination may allow for...
New neurons are continuously produced in the subgranular zone of the dentate gyrus of the hippocampus throughout life. These newborn dentate granule cells (DGCs) undergo a stereotyped process of morphological and functional maturation during the first few weeks after differentiation that recapitulates some aspects of postnatal neuronal development. The inhibitory...
Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are two devastating neurodegenerative diseases that affect 100,000s of people globally. They have a severe adverse impact on society, yet there are currently no early diagnostic tools or disease-modifying therapies available. Despite their clinical heterogeneity, evidence points to these diseases being on...