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-
- Description:
- Episodic memory provides a means by which we are able to reflect on the past, make decisions about the future, and form a learned identity. Even subtle changes to our memory can have a detrimental impact on our daily lives. Memory declines as we age, and clinically salient impairment is...
- Keyword:
- aging, hippocampus, transcranial magnetic stimulation, precision, recollection, and human memory
- Subject:
- Cognitive psychology, Aging, and Neurosciences
- Creator:
- Nilakantan, Aneesha S
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_674620 and http://dissertations.umi.com/northwestern:14737
-
- Description:
- Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are non-selective cation channels expressed in the brain and heart where they exert control over many diverse physiological properties. In the hippocampus, HCN channels are enriched in a dendritic gradient within CA1 pyramidal cells where they reduce dendritic integration and dampen neuronal excitability. HCN channels...
- Keyword:
- Temporal Lobe Epilepsy, HCN channels, Phosphorylation, and TRIP8b
- Subject:
- Neurosciences
- Creator:
- Foote, Kendall Marie
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_682272 and http://dissertations.umi.com/northwestern:14781
-
- Description:
- Decision making is an essential and indispensable element in everyday life. It is posited that parallel, distinct systems subserving deliberative, goal-directed control and automatic, habitual control underlie decision making. Computational accounts suggest that model-based and model-free learning strategies give rise to these two systems respectively. The model-based system is a...
- Keyword:
- Reward, fMRI, and Decision making
- Subject:
- Neurosciences
- Creator:
- Zhong, Wanting
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14552 and etdadmin_upload_647965
-
- Description:
- For years, neuroscientists have strived to understand memory consolidation, where salient memories are sorted and organized into distributed cortical networks for long-term storage. A large body of sleep research suggests that slow-wave sleep is an optimal opportunity for memory consolidation, and that consolidation is driven, at least in part, by...
- Keyword:
- olfactory reactivation, functional MRI, slow-wave sleep, ventromedial prefrontal cortex, memory replay, and memory consolidation
- Subject:
- Neurosciences
- Creator:
- Shanahan, Laura Kathleen
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14493 and etdadmin_upload_634332
-
- Description:
- This thesis focuses on the development of a cochlear implant (CI) that uses photons to stimulate surviving auditory neurons in severe-to-profoundly deaf individuals. The benefit of optical over electrical stimulation is its spatial selectivity with the potential to create significantly more independent channels to encode acoustic information and likely enhances...
- Subject:
- Audiology, Psychology, and Neurosciences
- Creator:
- Xu, Yingyue
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14587 and etdadmin_upload_660188
-
- Description:
- The brain is known to shrink in normal aging or neurodegenerative disease and yet the neurobiological underpinnings of the cortical atrophy remain elusive. The structural changes that represent cortical atrophy can be measured during life using the reliable and quantitative method known as magnetic resonance imaging (MRI). Primary progressive aphasia...
- Keyword:
- primary progressive aphasia, neurons, cortical atrophy, activated microglia, and Alzheimer's disease
- Subject:
- Pathology, Medical imaging, and Neurosciences
- Creator:
- Ohm, Daniel Timothy
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_640035 and http://dissertations.umi.com/northwestern:14532
-
- Description:
- Slow-wave sleep (SWS) is important for overall health since it affects many physiological pathways from cardio-metabolic health to cognitive function. Sleep and autonomic nervous system (ANS) functioning are closely coupled at anatomical and physiological levels. Sleep-related changes in ANS function are likely the main pathway through which SWS affects many...
- Keyword:
- Memory, Sleep, Acoustic Stimulation, Aging, Autonomic Nervous System, and Mild Cognitive Impairment
- Subject:
- Neurosciences
- Creator:
- Papalambros, Penelope Ann
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_635017 and http://dissertations.umi.com/northwestern:14497
-
- Description:
- Store-operated Ca2+ entry (SOCE) is a principal mechanism for generating cellular Ca2+ signals. Store-operated Ca2+ release-activated Ca2+ (CRAC) channels serve an essential role in generating Ca2+ elevations needed for transcriptional, enzymatic, and secretory effector cascades in many cell types. CRAC channels, comprised of the ER Ca2+ sensor STIM and the...
- Subject:
- Biology and Neurosciences
- Creator:
- Toth, Anna
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14766 and etdadmin_upload_679006
-
- Description:
- Rhythmic oscillations in the brain are widespread. Extracellular recordings of local field potentials (LFPs) using methods ranging from microelectrodes to scalp electroencephalography (EEG) have demonstrated that oscillatory dynamics play a vital role in operations such as network synchronization, sensory tuning and information packaging. Empirical and computational evidence suggest that these...
- Subject:
- Neurosciences
- Creator:
- JIang, Han
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_641773 and http://dissertations.umi.com/northwestern:14545
-
- Description:
- Frontotemporal dementia (FTD) encompasses a group of neurodegenerative disorders characterized by cognitive and behavioral impairments. Heterozygous mutations in progranulin (PGRN) cause familial FTD and result in decreased PGRN expression, while homozygous mutations result in complete loss of PGRN expression and lead to the neurodegenerative lysosomal storage disorder neuronal ceroid lipofuscinosis...
- Keyword:
- Progranulin, Frontotemporal Dementia, Lysosome, and Cathepsin D
- Subject:
- Neurosciences
- Creator:
- Valdez, Clarissa
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2017-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14449 and etdadmin_upload_626172
-
- Description:
- The presence of subjective cognitive decline (SCD) among cognitively normal-for-age older adults is increasingly hypothesized to represent a preclinical stage in the development of Alzheimer’s dementia (Jessen et al., 2014). This project aimed to characterize this construct with regard to its cognitive, motor, emotional, and functional features. The first study...
- Keyword:
- subjective cognitive decline, cognitive aging, and Alzheimer's disease
- Subject:
- Clinical psychology and Neurosciences
- Creator:
- Kielb, Stephanie
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14814 and etdadmin_upload_685763
-
- Description:
- One of the most fascinating observations in the brain is that the neural connections change with experience and this phenomenon is called synaptic plasticity. Patterns of activity or neuromodulators can acutely induce changes in the synaptic strength in the brain. My thesis is focused on understanding the mechanisms of plasticity...
- Keyword:
- LTP, PKA, Synaptic potentiation, and Sex differences
- Subject:
- Neurosciences
- Creator:
- Jain, Anant
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_676778 and http://dissertations.umi.com/northwestern:14753
-
- Description:
- Birds such as the barn owl and zebra finch are known for their remarkable hearing abilities that are critical for survival, communication and vocal learning functions. A key to achieving these hearing abilities is the speed and precision required for the temporal coding of sound; a process heavily dependent on...
- Keyword:
- Development, Tonotopy, Voltage dependent sodium channel, Auditory system, Voltage dependent potassium channel, and Nucleus magnocellularis
- Subject:
- Neurosciences
- Creator:
- Hong, Hui
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14516 and etdadmin_upload_638995
-
- Description:
- We have a remarkable ability to perform complex, coordinated movements without much conscious effort. In addition to the computations required to generate commands for muscles, a key aspect of coordinated motor control is incorporating sensory feedback about the movement. One of the most important feedback routes is through proprioception, the...
- Keyword:
- musculoskeletal model, somatosensory cortex, reaching, motion tracking, monkey, and cat hindlimb
- Subject:
- Biomedical engineering and Neurosciences
- Creator:
- Chowdhury, Raeed Hasan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14692 and etdadmin_upload_666011
-
- Description:
- After stroke, inappropriate muscle activity phasing during the locomotor cycle is a key contributor to locomotor impairment. Muscle phasing has been shown to vary between behaviors post-stroke, but the degree to which individuals can voluntarily modulate activity is unclear. This dissertation consists of a series of three studies that investigate...
- Subject:
- Neurosciences
- Creator:
- Mullens, Christopher Howard
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14729 and etdadmin_upload_672305
-
- Description:
- The apolipoprotein E (APOE) E4 isoform is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). While APOE is predominantly expressed by astrocytes in the central nervous system, neuronal expression of APOE is of increasing interest in age-related cognitive impairment, neurological injury, and neurodegeneration. Here we show that endogenous...
- Keyword:
- APOE, Alzheimer, Stem Cells, and CRISPR
- Subject:
- Molecular biology, Medicine, and Neurosciences
- Creator:
- Wadhwani, Anil R
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14520 and etdadmin_upload_639542
-
- Description:
- We perform many movements every day without much deliberation. However, moving can be seen as a form of decision-making since one of many possible movements must be selected and executed. The decision-making processes that underlie movements are influenced by various factors, including sensory perception, energetics, time, perceived rates of failure...
- Keyword:
- hind brain, reticulospinal, decision, escape, spinal cord, and looming
- Subject:
- Biomedical engineering, Neurosciences, and Biomechanics
- Creator:
- Bhattacharyya, Kiran
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_653282 and http://dissertations.umi.com/northwestern:14560
-
- Description:
- Identifying key molecular mechanisms and targets for therapeutic development in sporadic neurodegenerative diseases has been challenging. Therefore, in-depth investigation of genetic forms of disease can provide valuable insight into pathogenic disease mechanisms. The discovery of genetic forms of Parkinson’s disease (PD) has highlighted the importance of the autophagy/lysosomal and mitochondrial/oxidative...
- Subject:
- Neurosciences
- Creator:
- Nguyen, Maria Bac-Ai
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14484 and etdadmin_upload_630756
-
- Description:
- Recent studies have begun to examine white matter connectivity aberrations in psychiatric populations, such as major depressive disorder. Several studies have found reduced white matter integrity (WMI) in depressed samples, though the location of this reduction is not clear. Incorporating symptom measures of depression severity and rumination may allow for...
- Keyword:
- rumination, women's health, depression, and white matter
- Subject:
- Clinical psychology, Psychology, and Neurosciences
- Creator:
- Satyshur, Maureen
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_676234 and http://dissertations.umi.com/northwestern:14751
-
- Description:
- New neurons are continuously produced in the subgranular zone of the dentate gyrus of the hippocampus throughout life. These newborn dentate granule cells (DGCs) undergo a stereotyped process of morphological and functional maturation during the first few weeks after differentiation that recapitulates some aspects of postnatal neuronal development. The inhibitory...
- Keyword:
- running, Fragile X, adult neurogenesis, GABA, dentate gyrus, and synapse
- Subject:
- Neurosciences
- Creator:
- Remmers, Christine L
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_634151 and http://dissertations.umi.com/northwestern:14492
-
- Description:
- Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are two devastating neurodegenerative diseases that affect 100,000s of people globally. They have a severe adverse impact on society, yet there are currently no early diagnostic tools or disease-modifying therapies available. Despite their clinical heterogeneity, evidence points to these diseases being on...
- Keyword:
- microRNA, Compositional Data Analysis, TDP-43 Proteinopathy, FUS Proteinopathy, RNA-Seq, and Mitochondria
- Subject:
- Molecular biology, Bioinformatics, and Neurosciences
- Creator:
- McGee, Warren A
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14675 and etdadmin_upload_663037
-
- Description:
- The cerebellum is involved in sensorimotor processing and motor control in the brain. What has been found across many species for many behaviors is cerebellar Purkinje (Pkj) cells and cerebellar nuclear (CbN) cells show activity that is related to and predictive of movements. Less is known about how patterns of...
- Subject:
- Neurosciences
- Creator:
- Brown, Spencer T
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_669457 and http://dissertations.umi.com/northwestern:14720
-
- Description:
- In mature neurons, postsynaptic NMDARs are segregated into two populations, synaptic and extrasynaptic NMDARs, which differ in localization, function, and associated intracellular cascades. These two pools are connected via lateral diffusion, and receptor exchange between them modulates synaptic NMDAR content (NMDAR-plasticity). Here, we identify the phosphorylation of the PDZ-ligand of...
- Keyword:
- NMDAR, NMDAR-plasticity, Extrasynaptic NMDAR, GluN2B, and PP1
- Subject:
- Pharmacology and Neurosciences
- Creator:
- Chiu, Andrew Michael
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_669024 and http://dissertations.umi.com/northwestern:14717
-
Peripheral Neural Representations of Naturalistic Tactile Stimuli in the Vibrissal-Trigeminal System
- Description:
- Many species of rodents rely on the set of exquisitely sensitive facial vibrissae (whiskers) to guide rich behaviors in which other senses are inadequate. Although whiskers are, like all hairs, inert strands of keratin, they provide the animal with a rich landscape of tactile information which is used to guide...
- Keyword:
- Mechanics, Afferent, Vibrissal, Trigeminal, and Whisker
- Subject:
- Neurosciences
- Creator:
- Bush, Nicholas E
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14697 and etdadmin_upload_666783
-
- Description:
- Contactin associated protein like 2 (CNTNAP2) has emerged as a prominent susceptibility gene implicated in multiple complex neurodevelopmental disorders, including autism spectrum disorders (ASD), intellectual disability (ID), and schizophrenia (SCZ). The presence of seizure comorbidity in many of these cases, as well as inhibitory neuron dysfunction in Cntnap2 knockout (KO)...
- Keyword:
- Epilepsy, Dendrites, Autism, CASK, CNTNAP2, and Interneurons
- Subject:
- Physiology, Molecular biology, and Neurosciences
- Creator:
- Gao, Ruoqi
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14243 and etdadmin_upload_595693
-
- Description:
- Motor planning is fundamental to the performance of everyday reaching movements. The influence of planning is not limited to voluntary movements but extends to involuntary movements initiated in response to sensory stimuli, such as postural perturbations applied to the arm. Stroke alters voluntary reaching and the involuntary response to perturbations,...
- Keyword:
- Startle, Stroke, Motor Planning, and Reaching
- Subject:
- Biomedical engineering and Neurosciences
- Creator:
- Heckman, Rosalind Lauren
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_625731 and http://dissertations.umi.com/northwestern:14442
-
- Description:
- Neurodegenerative diseases (NDs) commonly involve the accumulation and aggregation of neurotoxic proteins that impair and ultimately destroy specific neurons. Considerable evidence from human and animal studies indicates that many NDs show disrupted circadian and sleep as symptoms. Yet little is known about the molecular mechanisms by which genes cause NDs...
- Keyword:
- genetic screen, neurodegeneration, Huntington’s disease, and circadian
- Subject:
- Biology and Neurosciences
- Creator:
- Xu, Fangke
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14655 and etdadmin_upload_662687
-
- Description:
- Dystonia is a movement disorder characterized by involuntary and repetitive co-contractions of the agonist and antagonist muscles. Dystonia 6 (DYT6) is an autosomal dominant dystonia caused by loss of function mutations in the zinc finger transcription factor THAP1. I have generated Thap1 knock-out mice with a view to understanding its...
- Subject:
- Neurosciences
- Creator:
- Frederick, Natalie
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14680 and etdadmin_upload_663120
-
- Description:
- Spinal cord injury (SCI) is a devastating injury, which can be caused by motor vehicle accidents, violence, and non-traumatic causes. These injuries can leave patients with lifelong paralysis, as well as incontinence and life threatening autonomic dysreflexia. There is currently no FDA approved treatment for SCI. Spinal injury disrupts the...
- Keyword:
- Nanotechnology, Fibronectin, Spinal Cord Injury, Fibrosis, Mechanical Properties, and Gliosis
- Subject:
- Biology, Biomechanics, and Neurosciences
- Creator:
- Cooper, John Gregory
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14557 and etdadmin_upload_650745
-
- Description:
- Individuals following a stroke suffer from a host of movement impairments that affect the upper extremity. Hand use is often significantly compromised, especially in individuals with more severe impairments, which makes it difficult for individuals to participate in activities of daily living. One of the major goals of rehabilitation is...
- Keyword:
- Upper Extremity, Stroke, Neuroimaging, Hand, Rehabilitation, and EEG
- Subject:
- Neurosciences
- Creator:
- Wilkins, Kevin Bryant
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14743 and etdadmin_upload_675263
-
- Description:
- Rhythmic fluctuations of electrical activity in the brain provide insights into the proposed mechanism by which we encode experiences and then maintain, forget, modify, and retrieve them. Yet there is still much to learn about how neural oscillations relate to memory function. The purpose of this research is to discover...
- Keyword:
- EEG, Memory, Oscillation, Reactivation, Sleep, and Consolidation
- Subject:
- Cognitive psychology, Psychology, and Neurosciences
- Creator:
- Creery, Jessica Danielle
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_615973 and http://dissertations.umi.com/northwestern:14395
-
- Description:
- To survive, animals, including human beings, have developed an amazing ability to learn the constantly changing environment. Specifically, detecting specific odorants in a noisy, variable background is crucial for finding food and water, mating, and avoiding potential dangers. For this purpose, rodents have developed an olfactory system that is powerful...
- Keyword:
- Synchronization, Olfactory Bulb, Neuron, Structural Plasticity, Learning, and Rhythms
- Subject:
- Applied mathematics and Neurosciences
- Creator:
- Meng, Hongyu
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/28/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14966 and etdadmin_upload_713722
-
- Description:
- Maneuvering your limbs requires both accurate commands for how to move, and accurate feedback of their true movements. Conventional prosthetic arms currently lack this sense of proprioceptive feedback, which can make daily tasks difficult without close visual monitoring. Although studies have successfully provided artificial proprioceptive feedback to improve control, this...
- Keyword:
- motor adaptation, sensory feedback, and myoelectric prosthesis
- Subject:
- Biomedical engineering and Neurosciences
- Creator:
- Earley, Eric Joseph
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/28/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_713001 and http://dissertations.umi.com/northwestern:14963
-
- Description:
- Neurons are sensitive to the mechanical properties of their environment and show better growth, survival and differentiation when they are cultured in soft environments with mechanical properties similar to those of the brain compared to other tissues. Within the central nervous system (CNS), there is also a range of mechanical...
- Keyword:
- Hydrogels, Peptide amphiphiles, Mechanical properties, aza-glycine, Neurons, and Supramolecular
- Subject:
- Chemistry, Biomedical engineering, and Neurosciences
- Creator:
- Godbe, Jacqueline M
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/28/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15006 and etdadmin_upload_719165
-
- Description:
- Episodic memory provides a means by which we reflect on the past, make decisions about the future, and form a learned identity. Episodic memory depends on the hippocampus as well as on the distributed set of regions that form a hippocampal-cortical network (HCN), including medial prefrontal, posterior cingulate, and medial...
- Keyword:
- memory, hippocampus, brain network, and stimulation
- Subject:
- Neurosciences
- Creator:
- Warren, Kristen N
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14985 and etdadmin_upload_717587
-
- Description:
- In susceptible individuals, episodic memories of overwhelmingly stressful experiences can give rise to debilitating socio-affective symptoms, including social dysfunction. This occurs even when such memories are not easily accessed for retrieval. In this case, it is generally accepted that the restricted retrieval of such memories is due to their having...
- Keyword:
- Chemogenetics, Hippocampus, Stress, Dentate gyrus, Social behavior, and Oxytocin
- Subject:
- Neurosciences
- Creator:
- Meyer, Mariah Alexie Azuz
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_718313 and http://dissertations.umi.com/northwestern:14995
-
- Description:
- The hippocampus has been identified as a critical structure for supporting spatial memory processes in both humans and animals alike. Many of these processes such as the ability to self-localize in a given environment as well as engage in goal-directed navigation are thought to depend on the location-specific firing of...
- Subject:
- Behavioral sciences, Biophysics, and Neurosciences
- Creator:
- Adoff, Michael David
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_718033 and http://dissertations.umi.com/northwestern:14990
-
Exploring the effects of phonetic overlap and background noise on incremental processing in children
- Description:
- In everyday conversation, individuals actively process speech in order to comprehend and respond in real-time. As a word unfolds, listeners activate possible lexical candidates and actively determine the target word as they receive more information, a process referred to as incremental processing. This process requires knowledge of one’s native spoken...
- Keyword:
- background noise, phonetic overlap, and incremental processing
- Subject:
- Neurosciences
- Creator:
- Sophia Liu
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 06/08/2020
- Date Modified:
- 07/23/2020
- Date Created:
- 2020-06-01
- Resource Type:
- Conference Proceeding
-
- Description:
- Dynamic decision-making is a complex process that relies on our ability to generate, evaluate and implement a variety of strategies. Understanding how people navigate this process is a difficult problem that requires a wide range of methodologies. This study details a combination of behavioral experiments, computational modeling, and neuroimaging that...
- Keyword:
- Memory Systems, Decision Making, Computational Neuroscience, Learning, Cognitive Modeling, and Category Learning
- Subject:
- Cognitive psychology, Psychology, and Neurosciences
- Creator:
- Reuveni, Ben
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15045 and etdadmin_upload_732002
-
- Description:
- Brain network organization, the emergence of cognition, and the accumulation of neurodegenerative pathology are interwoven concepts frequently studied under the umbrella of behavioral neurology, neuropsychiatry, neuropsychology, and neuropathology. One approach to studying the organization of cognitive processes is to study those with selective deficits in such networks. To understand how...
- Keyword:
- primary progressive aphasia, cortical atrophy, neuroimaging, Alzheimer disease, and brain networks
- Subject:
- Pathology, Medical imaging, and Neurosciences
- Creator:
- Martersteck, Adam Christopher
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_743337 and http://dissertations.umi.com/northwestern:15111
-
- Description:
- The basal ganglia are a remarkably complicated and interconnected tangle of subcortical nuclei whose exact function and composition are hotly debated to this day. What is plainly obvious, however, is that loss of dopaminergic modulation in the basal ganglia, as is the case in Parkinson’s disease (PD) following the progressive...
- Keyword:
- in vivo electrophysiology, anesthesia, basal ganglia, optogenetics, and 6-hydroxydopamine
- Subject:
- Neurosciences
- Creator:
- Kovaleski, Ryan Francis
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_720363 and http://dissertations.umi.com/northwestern:15020
-
- Description:
- The mammalian retina contains three classes of photoreceptors: rods, cones and the recently discovered intrinsically photosensitive retinal ganglion cells (ipRGCs). ipRGCs express the photopigment melanopsin and were initially thought to be a homogeneous population of cells that drive subconscious visual behaviors such as circadian photoentrainment and pupil constriction. However, recent...
- Subject:
- Neurosciences
- Creator:
- Sonoda, Takuma
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15030 and etdadmin_upload_724350
-
- Description:
- Interactions between working memory and long term memory systems are still not well understood, as the systems have long been thought to be mostly separate. An interesting intersection of these memory systems is domain-specific expertise, whereby individuals are able to show supra-span memory for information related to the area of...
- Keyword:
- Domain-specific expertise, Long term memory, Working memory, and Expertise
- Subject:
- Psychology and Neurosciences
- Creator:
- Gigler, Kathryn Lee
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_743356 and http://dissertations.umi.com/northwestern:15112
-
- Description:
- Voltage-gated Na channels are expressed in all neurons, and are responsible for the upstroke of the action potential. They are part of a complex of proteins that includes pore-forming α subunits and auxiliary subunits that modify their trafficking, gating, and function. The modulation of Na channels by auxiliary subunits is...
- Keyword:
- sodium channels, FGF14, resurgent current, beta4, and purkinje cells
- Subject:
- Neurosciences
- Creator:
- White, Hayley Virginia
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15070 and etdadmin_upload_740150
-
- Description:
- Background: Glioblastoma (GBM) tumors are the most malignant brain cancers and are characterized as Grade IV astrocytomas by the World Health Organization. GBM tumors can be classified into three molecular subtypes known as proneural, classical, and mesenchymal. In addition, GBM tumors also have a small population of cells known as...
- Keyword:
- LY6K, Methylation, Glioblastoma, ERK1/2, and CAV-1
- Subject:
- Molecular biology, Oncology, and Neurosciences
- Creator:
- Sastry, Namratha G
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_733180 and http://dissertations.umi.com/northwestern:15049
-
- Description:
- Stroke is the leading cause of permanent adult disability. Subcortical unilateral (hemiparetic) stroke affecting the internal capsule or basal ganglia is the most common of all strokes and usually results in hemiparesis of the contralateral arm and leg. About 80% of the individuals with a moderate to severe hemiparetic stroke...
- Keyword:
- Sensorimotor pathways, brainstem, stroke, spinal cord, and magnetic resonance imaging
- Subject:
- Neurosciences
- Creator:
- Karbasforoushan, Haleh
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15187 and etdadmin_upload_754987
-
- Description:
- Leptin, a peptide mainly secreted in proportion to adipose tissue mass, increases energy expenditure with a parallel increase in breathing. The existence of a leptin-mediated neural circuit linking breathing to metabolism has been speculated, yet the precise central mechanisms were unknown. In my thesis, I show that optogenetic activation of...
- Keyword:
- NALCN, obesity, and Nucleus of the Solitary Tract
- Subject:
- Neurosciences
- Creator:
- Do, Jeehaeh
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_763656 and http://dissertations.umi.com/northwestern:15246
-
- Description:
- Mitochondrial complex I is the primary entry point for electrons into the mitochondrial electron transport chain that is composed of 45 individual protein subunits that are encoded in both the nuclear and mitochondrial genomes. Mitochondrial complex I sits at an important nexus in the essential bioenergetic, biosynthetic, and signaling functions...
- Keyword:
- NDI1, NDUFS2, NDUFS4, Mitochondria, Leigh Syndrome, and Metabolism
- Subject:
- Biology, Aging, and Neurosciences
- Creator:
- McElroy, Gregory Scott
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_746970 and http://dissertations.umi.com/northwestern:15152
-
- Description:
- Considerable progress has been made in characterizing the neural circuits that underlie stress, fear, feeding, and pain. However, little is known about how they affect each other. Stress bidirectionally regulates feeding, either increases (e.g., stress-induced binge eating) or decreases (e.g., stress-induced anorexia), depending on the types of stressors, duration of...
- Keyword:
- LTD, feeding, locus coeruleus, endocannabinoid, and fear
- Subject:
- Neurosciences
- Creator:
- Yang, Ben
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15324 and etdadmin_upload_770239
-
- Description:
- The interaction of amyloid-β (Aβ) with endogenous metal ions is thought to play a role in the pathogenesis of Alzheimer’s disease (AD). However, limited tools exist to study and modulate Aβ-metal binding. The Meade lab has developed cobalt(III) Schiff base (Co(III)-sb) complexes as protein inhibitors that competitively displace metals from...
- Keyword:
- amyloid-beta, aggregation, cobalt(III) Schiff base, and coordination complex
- Subject:
- Biology, Biochemistry, and Neurosciences
- Creator:
- Roberts, Kaleigh Filisa
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_773649 and http://dissertations.umi.com/northwestern:15349
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