Three in ten people worldwide lack access to a safely managed source of drinking water, with one in ten lacking access to a drinking water service altogether. This is projected to worsen in the coming years as climate change, infrastructure degradation, and poor governance work to further increase global water...
Advances in biosensor engineering have enabled the design of programmable molecular systems to detect a range of pathogens, nucleic acids, and chemicals. Here, we engineer and field-test a biosensor for fluoride, a major groundwater contaminant of global concern. The sensor consists of a cell-free system containing a DNA template that...
Spherical Nucleic Acids (SNAs) are nanoparticle bioconjugates that have found use in a wide-range of diagnostic and therapeutic applications. These nanomaterials are composed from inorganic or organic core nanoparticle scaffolds that are functionalized with a dense surface layer of nucleic acids (typically DNA or RNA) that are oriented in a...