Prostate cancer (PCa) is the second most common cancer in American men and has led to approximately 29K deaths in 2018. The androgen signaling pathway plays a pivotal role in the pathogenesis of PCa, and androgen deprivation therapy (ADT) has been the main therapeutic approach for PCa. However, almost all...
Discrete molecules, linear and branched polymers, and disordered cross-linked networks are well studied objects of chemical synthesis. However, two-dimensional polymers (2DPs) have been long missing from this continuum of molecular architectures, both in chemical synthesis and in Nature. Recently, new polymerization strategies and characterization methods have enabled the unambiguous realization...
From visualizing thousands of social relationships, operationalizing measures that offer us insight into our theories, to characterizing cultural change over the span of centuries, computational methods appear to provide sociology a means to reveal patterns otherwise unknowable. While these methods are persistently critiqued for their inability to generate social theory,...
The BCR-ABL negative Myeloproliferative Neoplasms (MPNs) are clonal hematopoietic stem-cell disorders characterized by abnormal proliferation of differentiated myeloid lineages. MPNs include 3 clinically distinct disorders: Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF). 95% of MPNs are characterized by driver mutations in Janus Kinase 2 (JAK2), Thrombopoietin receptor...
The dissertation’s topic is the creation of quotidian judgements and practices related to food, amid the enduring social and spatial stratification of everyday life. The sites are two large and diverse cities: Paris and Chicago. The method is ethnographic and contextual.Chapter 1 documents the dietary tastes and culinary practices of...
ABSTRACT In the past two decades, the number of African and Afro-Caribbean immigrants arriving in the U.S. has been increasing. Black immigrants (36% of whom migrated from Africa and 50% from the Caribbean since 2000) now account for nearly 10% of the Black population in the U.S. This growing demographic...
This dissertation explores black litigation strategies, black legal culture, and the effect of black litigation on civil law. Not only did African Americans sue white southerners and white-owned companies for white-on-black violence under Jim Crow, they shared their collective legal knowledge through a network of black newspapers and contributed to...
Does the Russian Federation in the Putin-Medvedev era follow a grand strategy, and if so, what does it look like, and how can we discern the making of Russian grand strategy? However, Russian grand strategy is neither formally codified nor readily accessible, and it remains opaque at best. In this...
Throughout history, the development of materials has relied heavily on the empirical judgment of scientists and engineers and on prolonged experiments proton to errors. Due to the complexity of material behavior, successful discovery of new candidates has been serendipitous, and down-selection of candidates remains a time-consuming process that requires repetitive...
This dissertation investigates how US Americans in the nineteenth century began to apply the category of religious fanaticism to individuals and communities deemed dangerous. Contributing to scholarship on secularism, racial governance, and American religious history, this dissertation argues that fanaticism is not a neutral category of description. It tracks how...