Metabolic conditions affect the developmental tempo of most animal species. Consequently, developmental gene regulatory networks (GRNs) must faithfully adjust their dynamics to a variable time scale. We find evidence that weak repressors of gene expression provide the necessary coupling between GRN output and cellular metabolism. Using a mathematical model that...
Patients with sickle cell disease (SCD) experience lifelong struggles with both chronic and acute pain, often requiring medical intervention. Pain can be managed with medications, but dosages must balance the goal of pain mitigation against the risks of tolerance, addiction and other adverse effects. Setting appropriate dosages requires knowledge of...
Readme for Federal Circuit data file created by Melissa F. Wasserman and Jonathan D. Slack. The data file contains Federal Circuit opinions in each row and case/opinion attributes on the columns. The data file covers opinions issued from 10.13.2004 through 1.30.2018. This data file is the basis for the article...
The data file contains federal criminal cases as observations and case attribute variables. This data file is the basis for the article Discretion and Disparity in Federal Detention, 115 Nw. U. L. Rev. 1261 (2021), available at: https://scholarlycommons.law.northwestern.edu/nulr/vol115/iss5/1/. This data file is created with data from the U.S. Sentencing Commission...
American communities of color have shouldered a disproportionate share of the COVID-19 pandemic’s burden. For instance, at peak, Hispanic/Latino Americans experienced a weekly all-cause death burden 130.9% in excess of previous years. Not all excess deaths are directly attributable to COVID-19—there is emerging evidence that delays in care associated with...