During the 1870s and 1880s, state governments in the former slaveholding South established eleven public institutions for black higher learning. Given the volatile, impoverished, often repressive climate of the region, how did black political and educational leaders mobilize to expand state support for black higher education? Furthermore, how did they...
Cardiac Magnetic Resonance (CMR) is a promising non-invasive imaging technique capable of assessing cardiovascular function and anatomy for both adult and pediatric patients without the need for ionization energy. Even with the stated benefits, CMR utilization in the clinic is low (~1-2%) due in large part to long acquisition time...
Recent studies have shown that many high profile studies in biology could not be reproduced, calling into questions the legitimacy of their findings. These reports have the potential to greatly jeopardize the credibility of scientists in the field as well as erode public confidence in the scientific enterprise. Computational research...
Historically, there have been large disparities in the degree to which different communities have access to resources and representation within society. With the increased availability of the internet and the growth of user-generated content platforms like Twitter and Wikipedia, there are opportunities to alleviate some these long-standing barriers to access...
Promyelocytic leukemia (PML) nuclear bodies act as quality control centers in the nucleus, participating in a plethora of nuclear functions. As such, PML bodies are a signature model for functional nuclear organization. PML bodies have a dynamic protein composition that responds to changing conditions of the cell. Many of the...
Neisseria gonorrhoeae (Ng), a strict human pathogen, is the sole causative agent of gonorrhea. Gc possess a complex gene conversion system, the pilin antigenic variation system, (pilin Av), which alters the DNA sequence of the major pilin, PilE. Pilin Av results in the constant alteration of the surface exposed appendage,...
Chapter 1 presents analysis comparing the effectiveness of two mechanisms of regulation enforcement: (1) the frequency of inspections and (2) penalties for violations. Recent policy changes regarding enforcement of mining safety regulations are exploited to quantify the effectiveness of each mechanism. It is concluded that increasing the frequency of inspections...
Thinkers attempting to challenge existing conceptions of political life often find that they encounter limitations in dominant modes of spectatorship and communication. If popular audiences are unsuitably oriented toward the presentation of certain content, this introduces a fundamental obstacle for political theoretic efforts to shape ideas and interactions. This dissertation...
Mortgage brokers originate a large share of residential real estate lending. Exploiting state-level regulatory changes to local entry costs I am able to study the effect on credit quality and access. Using data from a major mortgage lender in the run up to the financial crisis I study how the...
The purpose of this multiple-case study was to examine the lived experiences of current collegiate music education majors, both students from under-represented minorities and their well-represented peers, with attention to racial/ethnic identity and social class. Dyads of current music education students at 8 separate colleges/universities—a student from an under-represented racial...
Two-dimensional (2D) materials are a promising class of electronic materials that have generated great interest to improve and create new and existing technologies. The promise of this family of materials relies on their high surface-to-volume ratio and atomic thickness in addition to their unique (opto)electric properties. However, these morphological properties...
Synthesis opens the pathway to examine a plethora of complex structures. Whether the target is a naturally occurring compound or a proposed molecule never observed before, synthetic routes can be developed to help understand a variety of properties that the molecule can contain. Synthetic efforts have helped elucidate the absolute...
If I mistakenly hear you ask for directions to the “shore” when instead you asked for directions to the “store,” the miscommunication is probably an innocent mistake. If, on the other hand, a man misunderstands a woman’s refusal of his sexual advances as consent, the mistake seems like it might...
This dissertation explores an intellectual and political tradition that questioned the use of natural resources and the socioeconomic structures of rural Brazil in the early 20th century. “Organicist agrarianism” postulated an orderly transformation of the Brazil under the guidance of the state in the name of a natural and eternal...
Recent advances in combinatorial chemistry, synthetic biology, and ‘omics’ research require high-throughput methods for performing and analyzing thousands to millions of reactions in one day. However, it is a challenge to engineer high-throughput systems that can autonomously conduct and analyze such a large number of reactions in a generalizable and...
We perform many movements every day without much deliberation. However, moving can be seen as a form of decision-making since one of many possible movements must be selected and executed. The decision-making processes that underlie movements are influenced by various factors, including sensory perception, energetics, time, perceived rates of failure...
At the turn of the twentieth century, the Russian Orthodox Church established a dense network of social and material aid for thousands of migrants who travelled from the Russian and Austro-Hungarian Empires to find work in the United States. The church’s growth followed the path of Progressive Era industrialization, with...
In the United States and around the world, the growing energy demands and climate concerns necessitate renewable and efficient energy production. Thermoelectric materials could be one small part of this larger picture movement, but their high cost and low efficiency must be improved to realize commercial use. To decrease the...
The US yogurt market has been volatile in the last decade, marked by striking sales increases and dramatic market structure changes. According to an industry report, dollar sales of yogurt in 2017 reached $8.8 billion---a more than 80% increase from 2007. Such remarkable sales growth can be attributed to the...
This thesis forcuses on the development of the transition-edge sensor (TES) for various X-ray science applications, especially for synchrotron beamline experiments. The ultimate aim is to build a detector that has a higher energy resolution than semiconductor detectors, and a higher operation speed than crystal spectrometers. The possible applications include...
Histamine is a well-known potent mediator during the elicitation of IgE-mediated allergic diseases. The most robust, and potentially fatal, response of histamine is observed in patients with food allergy that undergo IgE-mediated anaphylaxis. The key mechanisms of the biology of histamine in allergic disease are well-established, however there are still...
Problems in interpersonal functioning are a major concern. In adults, interpersonal dysfunction is often investigated as it relates to personality disorders (PDs). In fact, researchers have argued that a core of interpersonal dysfunction is what defines personality disorders (Hopwood, Wright, Ansell, & Pincus, 2013). This is perhaps most evident for...
This dissertation explains the heterogeneous effects of armed conflict on sub-national governance in the North Caucasus. While acknowledging the role of inherited institutions, my multimethod investigation shows how they were strategically transformed during the breakup of the Soviet Union, creating unintended consequences and the basis for governance today. My main...
Nonlinear systems with many interacting components often exhibit behaviors that cannot be anticipated, even in principle, by only knowing the properties of the constituent parts and thereby emerge as a result of interactions between the parts. Examples of such systems range from power grids and financial markets to food networks...
The literature has established glucokinase (GCK) to be the principal hexokinase (HK) in the liver, operating as a glucose sensor to regulate glucose metabolism and lipid homeostasis. We have recently proposed Hexokinase Domain Containing-1 (HKDC1) to be a novel 5th HK with expression in the liver. Here, we reveal HKDC1...
Identifying key molecular mechanisms and targets for therapeutic development in sporadic neurodegenerative diseases has been challenging. Therefore, in-depth investigation of genetic forms of disease can provide valuable insight into pathogenic disease mechanisms. The discovery of genetic forms of Parkinson’s disease (PD) has highlighted the importance of the autophagy/lysosomal and mitochondrial/oxidative...
Public memory studies in rhetoric have typically neglected how we use shared memories to form, maintain, and pass down social norms through the objects we encounter and the practices we participate in during our everyday lives. This is especially true for children’s toys, because they are understood as essential objects...
Recent studies have begun to examine white matter connectivity aberrations in psychiatric populations, such as major depressive disorder. Several studies have found reduced white matter integrity (WMI) in depressed samples, though the location of this reduction is not clear. Incorporating symptom measures of depression severity and rumination may allow for...
New neurons are continuously produced in the subgranular zone of the dentate gyrus of the hippocampus throughout life. These newborn dentate granule cells (DGCs) undergo a stereotyped process of morphological and functional maturation during the first few weeks after differentiation that recapitulates some aspects of postnatal neuronal development. The inhibitory...
Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are two devastating neurodegenerative diseases that affect 100,000s of people globally. They have a severe adverse impact on society, yet there are currently no early diagnostic tools or disease-modifying therapies available. Despite their clinical heterogeneity, evidence points to these diseases being on...
Biological tubes are essential for animal survival, and their functions are highly dependent on tube shape. Analyzing the contributions of cell shape and organization to the morphogenesis of small tubes has been hampered by the limitations of existing programs in quantifying cell geometry on highly curved tubular surfaces and calculating...
The presence of unwanted biofilms on surfaces is a great concern for industrial, naval, and healthcare fields, and many other settings. To better inhibit, remove, or harness the properties of biofilms, an explanation of how specific structural or chemical features of biofilm matrix components leads to enhanced adhesion and persistence...
Flowing granular mixtures with species differing in some property, such as size, shape or density of the grains, tend to segregate (de-mix) during flow. Since flowing granular materials are common in industry, and since segregation is often unwanted and costly, understanding and mitigating segregation is an important concern in industrial...
This dissertation is a history of religious conservatism between 1880 and the onset of the Great Depression in 1929. Its main argument is that conservative religion in America, rather than being defined by fundamentalism, theological disputes, or cultural antipathy towards pluralism, was an outgrowth of a profound faith in capitalism...
The analytical paradigm in philosophy has as a pillar an analysis of the sentence as a basic entity. New sentences may be built from old sentences recursively through the application of logical constants, recently including intensional operators. Models are built on how these logical constants interact with each other, and...
Soft materials such as colloids and polymers often exhibit a variety of mesoscopic structures that are governed merely by weak physical interactions. Due to these intermediate structures, they can be easily taken out of thermal equilibrium by introducing external stimuli such as a shear flow and electromagnetic fields. This thesis...
While Li-ion batteries are currently the preferred energy storage technology, multivalent alternatives such as Mg should be considered. Magnesium metal has a high volumetric capacity and has been shown to cycle with no dendrite formation. However, the highly charged Mg2+ ion cannot easily diffuse into the oxide cathodes favored in...
This project traces the efforts by Scottish Protestants to achieve complete religious uniformity in the decades following the Reformation. Discontented with outward conformity, the via media that long characterized our understanding of religious reform in England, Scotland’s ministers sought to work genuine conversions among those who resisted the new order....
One of the grand challenges in science is development of soft materials that mimic living organisms to optimize the way we use energy, translate or morph reversibly or sense their envi- ronment and respond in a useful fashion. Using the insights from studying biological structures, we hope to design soft...
In this dissertation I study the effects of mortgage leverage policies. These policies have become widely used in recent years, both as a macroprudential tool and to protect consumers, yet their effects are still not well understood. In Chapter 1, I show that mortgage leverage rules implemented under the Dodd-Frank...
Deep neural networks have shown impressive performance for many applications. In this dissertation, leveraging the capabilities of neural networks for modeling the non-linearity exists in the data, we propose several models that can project data into a low dimensional, discriminative, and smooth manifold. The suggested models can transfer knowledge from...
This dissertation studies three distinct problems in econometrics. Chapter 1 proposes an adaptive randomization procedure for two-stage randomized controlled trials. The method uses data from a first-wave experiment in order to determine how to stratify in a second wave of the experiment, where the objective is to minimize the variance...
The cerebellum is involved in sensorimotor processing and motor control in the brain. What has been found across many species for many behaviors is cerebellar Purkinje (Pkj) cells and cerebellar nuclear (CbN) cells show activity that is related to and predictive of movements. Less is known about how patterns of...
Many human diseases are chronic and ultimately fatal because they damage organs and tissues beyond the body’s normal repair mechanisms. Therefore, there is significant medical interest in developing pharmaceuticals that enhance the body’s natural injury repair mechanisms and engineering organs in the lab for transplantation. However, comparatively little is known...
The emerging paradigm of quantum information science (QIS) vows to transform a wide range of fields, such as computation, communication, and sensing. The fundamental unit at the core of any QIS system is a quantum bit, or qubit. Rather than be restricted to one of two classical states (0 or...
As the global population grows, consumption of water, energy, and food will also increase, placing stresses on these sectors, raising the importance of the Water-Energy-Food Nexus (WEFN). However, operation of WEFN systems are currently not sustainable. It is thus crucial to design WEFN systems to be sustainable from local to...
This dissertation consists of three essays on corporate governance. In the first essay of the dissertation (“The Effects of Succession Planning on CEO Succession Events: Implications for Both Focal and Competing Firms”), I examine whether and how both focal and competing firms are affected by sudden CEO deaths. By using...
This dissertation examines how the maintenance and adaptation of heritage monuments and ritual traditions have contributed to the sustainability of communities on the islands of Inishark and Inishbofin along the west coast of Ireland. My analysis combines archaeological investigation of a pilgrimage tradition on Inishark, from its origins in the...
For women, age is one of the best predictors of fertility. Younger women are typically more fertile, and ability to conceive declines until a woman reaches menopause. However, the age at which an individual woman becomes less fertile varies depending on many factors unique to her individual body, including genetic...
This dissertation explores two factors that affect innovation. The first factor studied is extrinsic, namely, the legal environment. The second factor is a factor of input into innovation - culture of the inventors. The first chapter studies the impact of a weakened patent environment on research investments. Departing from the...