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Filtering by: Keyword Parkinson's disease Keyword autonomous activity Keyword subthalamic nucleus Subject Interdepartmental Neuroscience Program (NUIN)

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Autonomous Subthalamic Nucleus Activity in a Mouse Model of Parkinson's Disease: Mechanisms of Disruption and Consequences of Its Restoration

Description:

Parkinson's disease (PD) is a movement disorder that arises following the degeneration of dopamine-producing neurons of the substantia nigra pars compacta (SNc). Patients experience a host of limiting motor symptoms such as rigidity, tremor, and a paucity of controlled movement generation. These symptoms often correspond with a predominance of abnormally...

Keyword:

KATP channel, chemogenetics, basal ganglia, subthalamic nucleus, Parkinson's disease, and autonomous activity

Subject:

Interdepartmental Neuroscience Program (NUIN)

Creator:

Eileen McIver

Owner:

Scholarly Digital Publishing

Date Uploaded:

10/21/2019

Date Modified:

10/21/2019

Date Created:

2018-01-01

Resource Type:

Dissertation

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Autonomous Subthalamic Nucleus Activity in a Mouse Model of Parkinson's Disease: Mechanisms of Disruption and Consequences of Its Restoration