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The Role of Alpha-Synuclein Aggregation in Endoplasmic Reticulum Protein Folding and Homeostasis

Description:

Protein homeostasis, or proteostasis, is essential for preserving all cellular functions and involves a balance of protein synthesis, folding, trafficking, and degradation. A collapse in proteostasis is a common feature of many neurodegenerative disorders that are characterized by the accumulation of insoluble protein aggregates in the brain. Parkinson’s disease (PD)...

Keyword:

induced pluripotent stem cell models, ER stress, protein aggregation, protein folding, and lysosomal dysfunction

Subject:

Molecular biology and Neurosciences

Creator:

Stojkovska, Iva

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/02/2022

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_850723 and http://dissertations.umi.com/northwestern:15793
Examining prionogenic domains in the Swi1 protein, yeast evolution, and novel disease-related aggregators

Description:

Prions are self-perpetuating, alternative protein conformations associated with neurological diseases and normal cellular functions. Saccharomyces cerevisiae contains many endogenous prions – providing a powerful system to study prionization. Previously, the Li Lab demonstrated that Swi1, a component of the SWI/SNF chromatin-remodeling complex, can form the prion [SWI+]. A small region,...

Keyword:

[SWI+], yeast, protein aggregation, prions, Saccharomyces cerevisiae, and Swi1

Subject:

Molecular biology, Bioinformatics, and Neurosciences

Creator:

Goncharoff, Dustin Kenneth

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/28/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_816388 and http://dissertations.umi.com/northwestern:15538

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The Role of Alpha-Synuclein Aggregation in Endoplasmic Reticulum Protein Folding and Homeostasis

Examining prionogenic domains in the Swi1 protein, yeast evolution, and novel disease-related aggregators

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