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Examining prionogenic domains in the Swi1 protein, yeast evolution, and novel disease-related aggregators

Description:

Prions are self-perpetuating, alternative protein conformations associated with neurological diseases and normal cellular functions. Saccharomyces cerevisiae contains many endogenous prions – providing a powerful system to study prionization. Previously, the Li Lab demonstrated that Swi1, a component of the SWI/SNF chromatin-remodeling complex, can form the prion [SWI+]. A small region,...

Keyword:

[SWI+], yeast, protein aggregation, prions, Saccharomyces cerevisiae, and Swi1

Subject:

Molecular biology, Bioinformatics, and Neurosciences

Creator:

Goncharoff, Dustin Kenneth

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/28/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_816388 and http://dissertations.umi.com/northwestern:15538
Regulation of the Rsp5 HECT Domain Ubiquitin Ligase

Description:

Rsp5 is a ubiquitin ligase that controls a broad range of cellular processes in budding yeast and is part of a large family of proteins that controls analogous processes in mammalian cells. Although Rsp5 targets a number of different substrates for ubiquitination, the mechanisms that regulate Rsp5 catalytic activity are...

Keyword:

yeast, Rsp5, polyubiquitin chain, Nedd4, ubiquitin, and HECT

Subject:

Interdepartmental Biological Sciences Program

Creator:

Michael French

Owner:

Scholarly Digital Publishing

Date Uploaded:

09/20/2018

Date Modified:

09/20/2018

Date Created:

2008-12-03

Resource Type:

Dissertation

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Examining prionogenic domains in the Swi1 protein, yeast evolution, and novel disease-related aggregators

Regulation of the Rsp5 HECT Domain Ubiquitin Ligase

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