Nanocarriers are drug delivery vehicles that have at least one dimension at the nanoscale (10-9 m). Engineering the nanocarrier surface is a strategy for targeting drug delivery to specific cell types to enhance efficacy and minimize side effects. A useful analogy is to consider how the chassis of an automotive...
Vaccines, such as those against smallpox virus, polio virus, and yellow fever virus, have saved millions of lives. However, many infectious diseases, such as HIV-1, still lack a preventive vaccine. In addition, various vaccines, such as those against Influenza and SARS-CoV-2 require boosters and may not confer 100% lifelong protection...
Cyclic loading, from earthquake, has caused the instability and failure of slopes composed of sensitive clays. During the 1964 9.2 moment magnitude (M) earthquake in Anchorage, Alaska, several slopes comprised of Bootlegger Cove Formation (BCF) clays failed during the strong seismic motion. Some researchers have proposed the use of residual...
The cuprate superconductor HgBa$_2$CuO$_{4+\delta}$ (Hg1201) has one of the simplest physical structures of the cuprates making it an ideal candidate for nuclear magnetic resonance (NMR) measurements. Here we discuss our NMR experiments aimed at studying the mixed state of two under-doped single crystal Hg1201 samples at high magnetic fields.
This dissertation reports on a 16-week ethnographic study of politicized caring within a museum-based tinkering program for high school students called the FabYouth program. Drawing on a data set that includes 16 field notes, 785.83 minutes (about 13.1 hours) of ethnographic audio-video recordings, 280 photographs, and ten student interviews, I...
Realizing electromagnetic metamaterials which operate in the optical regime requires creating precise arrangements of sub-100 nm building blocks. As such, fabricating these materials using conventional lithographic methods is extremely costly. On the other hand, bottom-up assembly of nanoparticles into crystalline superlattices offers opportunities to explore the scalable fabrication of 2-...
In my dissertation, Knowing How to Feel: mapping affective epistemologies of ignorance through numbness, I examine the ways by which numbness contributes to harmful “epistemic resilience,” or the phenomenon whereby systems of meaning remain stable despite counter evidence or attempts to alter them (Dotson 2014). I am most importantly concerned...
Protein homeostasis, or proteostasis, is essential for preserving all cellular functions and involves a balance of protein synthesis, folding, trafficking, and degradation. A collapse in proteostasis is a common feature of many neurodegenerative disorders that are characterized by the accumulation of insoluble protein aggregates in the brain. Parkinson’s disease (PD)...
This dissertation examines the interactional mechanisms that undergird exercises of regulatory authority in expert work settings. In the first chapter, I argue that, in the aftermath of a crisis (in this case, induced by a major regulatory event), organizational actors face environments of high uncertainty which challenge rational models of...
In recent years, the social sciences have been ensnared in a crisis in which many research findings cannot be replicated (Ioannidis, 2005; Open Science Collaboration, 2015; Camerer et al., 2016; Makel & Plucker, 2014). This crisis has been attributed to a variety of problems including lack of transparency about research...
This dissertation addresses two distinct but related questions. First, how should we conceive of social freedom? Second, given this conception, what ideals would best satisfy the demands we are under as citizens and moral agents? In answer to the first question, I defend a novel account of social freedom, where...
Regulatory T (Treg) cells are required to control immune responses and maintain homeostasis, but are a significant barrier to antitumor immunity. Conversely, Treg instability, characterized by loss of the master transcription factor Foxp3 and acquisition of proinflammatory properties, can promote autoimmunity and/or facilitate more effective tumor immunity. A comprehensive understanding...
Existing nonlinear optimization methods have proven reliable over the past few decades for a wide range of applications but have critically relied on accurate function and gradient evaluations. Modern nonlinear optimization problems arising from machine learning and scientific computing applications are increasingly complex and large scale, which make accurate evaluations...
This dissertation reorients political theory to the concepts of use and utility for a more critical and emancipatory perspective on contemporary communal life. The reorientation entails a recovery of Aristotle’s and Marx’s overlapping approaches to use, whose contemporary reception indexes the surprising alignment of critical political theory with economics. That...
Semiconductor nanocrystals possess unique photophysical properties that make them desirable for many optoelectronic applications such as photovoltaics, LEDs, and quantum computing. When the size of a semiconductor is reduced to below the excitonic Bohr radius of the material, its carriers becomes quantum confined resulting in drastic changes to optical, electronic,...
Nanomaterials offer unique properties not seen in their macroscopic kin. They can be used in printed electronics, as catalysts, and so much more. However, their diminutive size complicates materials processing techniques. They can easily aggregate become no longer useful. A solution to this is to use a polymeric surfactant such...
The field of robot design mostly focuses on careful construction of complex control and planning algorithms (e.g., tuning neural network weights) which bear sole responsibility for improving task performance, while the robot’s body is often assumed to be part of the environment. In nature, however, biological organisms co-evolve both their...
One of the most pressing open questions in star formation is the role of magnetic fields relative to turbulence and gravity, and how these three processes set the stellar initial mass function and star formation efficiency. In this work, we present the state of BLAST-TNG (the Balloon-borne Large Aperture Submillimeter...
Critical pedagogies offer a particular orientation towards education that understands the process of learning as inherently political. These frameworks demand explicit political attention by teachers to support student development of practices needed to create a liberatory world. Recent work evidences the positive impact critical pedagogies have on students academically, civically,...
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease, affecting children and adults. Chemotherapy regimens show high response rates but have debilitating effects and carry risk of relapse. Until now, no targeted therapy has been approved. In addition, 40% of patients will relapse and their treatment options are limited because...
Language models are the foundation of many natural language tasks such as machine translation, speech recognition, and dialogue systems. Modeling the probability distributions of text accurately helps capture the structures of language and extract valuable information contained in various corpora. In recent years, many advanced models have achieved state-of-the-art performance...
The logistics of policy implementation can lead to a delay from when the actual change in behavior occurs, leading to a shift in a time series. Using change point analysis allows for the data to determine where a change in mean, or other parameters, occurred. But when policy is implemented...
We live in an increasingly computational world; one that, in the near term, may require everyone to be computationally literate. Computer science (CS) education has greatly increased its reach in the last two decades with an increasing number of students having access to formal computer science classroom experiences in the...
Materials science has been central to human advancement since time immemorial. There has always been curiosity around studying the processes required to extract materials, examine their structure, and ultimately tailor their properties to meet human needs. Over the last few centuries, the ability to tailor material properties was driven by...
To be tempted is to be conflicted, but the conflict is not one of oscillation between two good options. Rather, it is normally easy to act on temptation and difficult to act against it. But this is puzzling, because unless temptation is a force that acts on us, it’s not...
Object Detection is a core computer vision problem and can facilitate many image understanding problems. Object Detection has witnessed significant progress in the past decade especially after deep learning is successfully applied to this field. Most of the detection models focus on generalizing the trained model to unseen samples of...
Engineering heat transport in materials is essential for thermal management in a wide range of technologies, from batteries to thermoelectrics. Materials host a wide spectrum of heat-carrying phonons, which vary in their frequency, spatial extent, and degree of plane-wave character. This diversity in phonon properties leads to complex behavior, especially...
In this dissertation, we aim to develop efficient algorithms with theoretical guarantees for several data-driven decision making problems. Specifically, we study the data-driven deci- sion making from three different perspectives: statistical learning, nonconvex optimization, and control of stochastic system. This dissertation contains three parts. In the first part, we study...
Nanocarriers as structures with at least one dimension in the nanometer scale are capable of loading small molecule therapeutics that would otherwise have poor bioavailability, non- specific uptake, and off target effects. Polymeric nanocarriers can be modified to tune their chemical and biological behavior to better suit the intended application....
The dissertation builds on my current research to demonstrate the connection between affect and learning through machine learning and qualitative analysis of interactions where players use a complex systems game. The project is threefold: First, I developed a thinking and learning intervention, the agent-based modeling simulation Ant Adaptation. I showed...
This dissertation consists of three studies related to parental employment, maternity leave policy, and early care and education. In study 1, my coauthor and I evaluate the impact of parenthood on men and women’s job performance and career advancement using detailed data from the U.S. Marines. For parents who remain...
This dissertation explores the poetry and culture of the late-Soviet era of Stagnation (1964-1985) through a broadly conceived cultural metaphor of stagnation. The five Russian poets and one American poet in this study- Viktor Krivulin, Alexei Parshchikov, Aleksandr Eremenko, Ivan Zhdanov, Elena Shvarts, and Lyn Hejinian- each engage with a...
The prospect of being evaluated by others is oftentimes psychologically crippling. At the core of feeling evaluated is perceiving other minds capable of possessing (judgmental) thoughts and feelings. While research on mind perception in evaluative situations oftentimes examines positive aspects (e.g., increased prosocial behavior), this dissertation looks into how mind...
Recent developments in deep learning have led to breakthroughs in rendering novel views from sparse input views of a scene.While the accuracy of these algorithms has improved dramatically, it has come at a huge computational cost.
While developments in graphics hardware have ameliorated some of the computational burdens, deep learning-based...
Coherent diffractive imaging (CDI) methods are techniques that image a sample by illuminating it with a coherent beam and recording the intensity diffraction pattern produced by the wavefront outgoing from the sample. These are lensless methods that are not limited in resolution by the physical characteristics of an objective lens,...
The demand for low cost, unconventional electronics requires new materials with unique characteristics that the traditionally used silicon-based technologies cannot provide. Metal oxide semiconductors, such has amorphous indium gallium zinc oxide (a-IGZO), have made impressive strides as alternatives to amorphous silicon for electronics applications. However, to achieve the full potential...
Soft functional materials are fundamentally interesting from a chemistry standpoint and have exciting applications in robotics, chemical and biomolecule sensing, and biomedical engineering. In addition, soft materials are also useful in lithography, particularly cantilever-free scanning probe lithography (CFSPL). Because of their low modulus, biocompatibility, stimuli responsiveness, malleability, and other characteristics,...
In a new analysis of Renaissance pastoral that draws on ecocriticism, queer theory, and a historicist approach, this dissertation finds a green and inhuman world that opposes the modern view that humans differ significantly from, and enjoy a right of dominion over, nonhuman species and the environment. Through readings of...
Like many diseases, atherosclerotic cardiovascular disease is driven by the activity of inflammatory cells. Using molecular imaging to target and analyze populations of inflammatory cells is one promising strategy to non-invasively assess atherosclerosis progression. However, current molecular imaging contrast agents are not suited for such targeted imaging applications. Nanomaterial-based strategies...
Metal–organic frameworks (MOFs) are a class of crystalline materials composed of metal nodes connected by organic linkers. Due to their high degree of synthetic tunability, MOFs have been considered for a wide range of applications, including many that rely on a change in oxidation state. While most MOFs are generally...
The purpose of this study was (1) to examine the impact that small ensemble free improvisation experiences had on dispositional empathy development when compared with other forms of collective music making; and (2) to examine the relationship between co-performing musicians’ empathy levels and their performance achievement in small ensembles using...
This dissertation imagines the near future of teamwork, when AI agents will join teams,interacting, collaborating, and completing tasks as a team member. Broadly, I seek to answer the
questions: how do humans integrate a new AI teammate onto their team, and how does the AI
teammate’s function influence this integration...
This dissertation examines the following puzzle: Why have antitrust (competition) laws and policies failed in their mission to prevent concentrations of economic power globally? Corporate monopolization has grown more acute in the last three decades and created serious problems in consumer and worker protection, economic stability, and democratic representation worldwide....
We investigated the relationships between trauma, depression, and pelvic pain severity in patients with chronic pelvic pain. Previous research has demonstrated that pelvic pain is associated with trauma history (e.g., physical and sexual abuse). As one potential mechanism of this relationship, trauma may lead to increased susceptibility to pain by...
This thesis studies Bayesian-robustness of algorithm design. The main perspective requires for a single fixed algorithm that its performance is an approximation of the optimal performance when its inputs are independent and identical draws (i.i.d.) from every unknown distribution which is an element of a known, large class of distributions....
Parasitic nematode infections are common in both humans and livestock populations around the globe. In humans, these infections cause illness which can be debilitating. In livestock, parasitic nematode infections result in poor animal health and wellbeing as well as decreases in the yield of these animals. The decrease in yield...
The treatment of AML remains to be a challenge due to the high rates of resistance and relapse experienced by patients after initial therapy. The MAPK-interacting kinases 1 and 2 (MNK1/2) have generated increasing interest as therapeutic targets for AML due to their critical role in malignant hematopoietic transformation via...
Among the most valuable applications of organometallic chemistry is its implementation in the field of catalysis. Many industrial processes rely heavily on catalysis, employing organometallic complexes in the production of commodity chemicals, fine chemicals, materials, and even in the discovery and development of pharmaceuticals. Through decades of intense study, homogeneous...
The Gram-negative Stenotrophomonas maltophilia is naturally found in water, soil and the plant rhizosphere, and is increasingly recognized as an important opportunistic and nosocomial infection. Despite its rising prevalence and drug resistance, there is little known about S. maltophilia pathogenesis. In this dissertation, I explored two aspects of S. maltophilia...
We prove the uniqueness of equilibrium states for certain potentials satisfying the Bowen property for two flows related to geodesic flows on surfaces with sufficient hyperbolicity. Our first result is the uniqueness of equilibrium states for Hölder continuous potentials and the geometric potential for products of geodesic flows of rank...
Light provides a high-speed and coherent medium for controlling quantum states. In semiconductors, coherent optical effects have been used extensively to lift spin degeneracy on ultrafast timescales and demonstrate high-fidelity control of quantum spin states. Extending this approach to novel pseudospins in monolayer transition metal dichalcogenides (TMDs), in this thesis...
This dissertation explores ways to utilize physical parameters at the nanoscale interface to control the properties of mixed-dimensional heterojunctions (MDHJs). MDHJs combine the desirable properties of different classes of low-dimensional nanomaterials (materials that are quantum confined in at least one dimension). While MDHJs have achieved superlative performance for a variety...
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by motor neuron (MN) degeneration and resulting in progressive paralysis and death. ALS is genetically heterogeneous, disease pathophysiology is not completely understood, and there are no effective drug therapies. To develop broadly applicable therapeutics, we examine disease mechanisms in the...
Superconducting qubits are among the leading competitors in the race towards building the first full-fledged quantum computer. Using this platform, researchers have for the first time demonstrated computational capability that is beyond the reach of the current classical machines. (This achievement is nicknamed "Quantum Supremacy".) Up to date, however, the...
The nature of dark matter (DM) remains one of the largest open questions in modern physics despite the many searches for particle dark matter around the world. The search for dark matter particles with masses above 5 GeV/$c^2$ is led by the dual-phase xenon time-projection chamber (LXe-TPC) detector technology which...
My research goal is to develop first principles frameworks to interrogate multiphase, multiscale systems. One of my main focus areas is to consistently deconstruct highly nonequilibrium problems into their fundamental components. By using analytical, computational and experimental tools to grasp the key levers controlling such phenomenon, I aim to build...
A major distinction among different skeletal muscles in the human body is the number, size, and arrangement of its cells, referred to as a muscle’s architecture. Muscle architecture is indicative of a muscle’s ability to contract and produce force and, like muscle function, is plastic. While neuromuscular plasticity is the...
This dissertation asks how can researchers more equitably design sociotechnical interventions to support the information work of sheltered emerging adults. Through two research studies, I explore the technology use in fulfilling the information needs among this population as well as how their environment impacts their strengths and information practices. I...
In an era of personalized medicine, the clinical community has become increasingly focused on understanding diseases at the cellular and molecular level. Magnetic resonance imaging (MRI) is a powerful imaging modality for acquiring anatomical and functional information. However, it has limited applications in field of molecular imaging due to low...
Movement is achieved by combining synaptic inputs from various sources and activating motor unit populations. Motor units are the quantal elements of motor control which act as a neuromechanical transducer that converts sensory inputs into motor output. Because of the tight neuromuscular junctions between motoneuron axon terminals and a large...
This dissertation addresses inter alia the problem of certain intertextual discontinuities across Thomas Hobbes’s oeuvre regarding the issue of ecclesiology. I find that these disparities did not result from a change in Hobbes’s private opinions, but from the regicide of 1649 as an event that liberated Hobbes to unveil his...
The BV Laplacian Δ, first introduced by Batalin and Vilkovisky, is a second-order differential operator that appears in the quantum master equation for quantizing gauge theories. The geometric framework for the BV formalism was later recognized by Schwarz as the setting of odd symplectic geometry and Khudaverdian showed that Δ...
Mitochondria-lysosome contacts are recently identified sites for mediating crosstalk between both organelles, but their role in normal and diseased human neurons remains unknown. We used super-resolution and live-cell microscopy in human iPSC-derived neurons to demonstrate that mitochondria-lysosome contacts can dynamically form in the soma, axons, and dendrites of human neurons,...
In this dissertation we consider how simple operational levers affect a firm's revenue and consumer surplus. In particular, we focus on information disclosure as an useful control for omnichannel services.In the first chapter we consider a revenue-maximizing service firm that caters to price and delay-sensitive customers. The firm offers a...
Theoretical and empirical inquiries into queer geographies have focused primarily on how white gay subjects navigate urban landscapes. Consequently, there has been little empirical work that examines (1) queer placemaking within Black and brown urban spaces; (2) placemaking among queer women of color; and (3) the relationship and interplay between...
Two-dimensional (2D) hybrid halide perovskites have been the response to their exciting but woefully unstable 3D counterparts. These 2D perovskites have been shown to have respectable stabilities as photovoltaic absorbers, yet they lag behind the 3D perovskites in terms of efficiency. With the need to catch up to the efficiencies...
Symbiotic relationships involve a life-long interaction between host and bacteria, and there is much we do not understand about how these interactions are developed and maintained. During the horizontal recruitment of beneficial bacteria by hosts, a complex set of molecular signals and communication ensures specificity. On the bacterial side, these...
This dissertation argues that silence played a fundamental role in the Victorian novel and in Victorian novel writing, operating as a productive force in service of sympathetic exchange and creative labor. It examines Charles Lamb's and Thomas Carlyle’s foundational roles in detaching silence from its traditional Romantic associations with solitude,...
Nucleic acids such as DNA or RNA of various lengths and structures have a wide scope of functions as therapeutic entities compared to conventional drugs. For instance, native and modified forms of nucleic acids can be used for gene silencing, genome editing, gene replacement, immune system modulation, and theranostics. While...
This dissertation proposes a theory that views beats as probabilistic domains that I term “pockets,” taking a vernacular term commonly used by jazz, funk, and popular music performers to describe the state of being in a good groove and making it concrete through empirical methods. Pockets have three key properties:...
A framework is developed that models point defect diffusion and interaction with pre-existing microstructures during irradiation, including defect-defect interactions and defect sinks. This framework uses a modified diffusion potential that includes not only defect concentration, but also intrinsic stresses from the pre-existing microstructure. Various microstructures are studied in {Fe} by...
The ubiquitous role of water in biochemical, electrochemical, and geochemical systems has driven scientific interest in studying the fundamental hydrogen-bonding interactions that water molecules exhibit in the presence of different materials.Specifically, we focus on the interactions characterizing water at the interface between two bulk media, as these are essential to...
The highly flexible nature of 2D materials has led to them becoming fundamental building blocks for achieving novel device physics and potential breakthroughs in practical technologies. 2D layers can be interfaced in a wide array of methods with themselves, other 2D layered materials, or materials of entirely different type or...
Metal halide perovskites have recently emerged as one of the most promising active layers in solar cells for their high power conversion efficiency (>25%) and ease of synthesis and deposition. Spatial heterogeneity is inevitable with current fabrication methods for both monocrystalline and polycrystalline perovskite thin films and crystals. The morphology-dependent...
Molybdenum oxides and sulfides are earth-abundant materials known to catalyze a wide array of reactions, including dehydrogenation, hydrotreating, and higher alcohols synthesis. In particular, alkane and alcohol dehydrogenation are of interest given recent shifts in the energy landscape away from traditional petroleum feedstocks and towards natural gas and renewable energy...
In this thesis, we study the homological mirror symmetry for the Gross-Siebert program of local mirror symmetry. We construct a pair of mirror objects by lifting a tropical curve in the integral tropical manifold of the Gross-Siebert program. Furthermore, we evaluate the central charges of the mirror objects and show...
The leptonic and inclusive hadronic decay branching fractions of the W boson are studied using 35.9 $fb^{-1}$ of proton-proton collision data collected at $\sqrt{s}=13~TeV$ during the 2016 run of the CMS experiment. Events characterized by the production of pairs of W bosons from \ttbar and \tW processes are selected. Multiple...
In this thesis, we aim to develop efficient algorithms with theoretical guarantees for noisy nonlinear optimization problems, with and without constraints, under various different assumptions. Apart from Chapter 1 which provides relevant backgrounds, the remaining of thesis is divided into four chapters. In Chapter 2, we establish the theoretical convergence...
Materials that exist as well-defined individual entities at the nanoscale typically have properties that sets them apart from their bulk form. Consequently, there has been much time and effort invested in developing new well-defined nanoscale entities, but few attempts to assemble them into bulk materials. On the other hand, there...
This dissertation aims to: 1) characterize the range of beliefs museum practitioners have about racial, ethnic, and cultural diversity; 2) their understanding of the role of race, culture, and ethnicity in minoritized learners’ sensemaking; and 3) the areas of tension and symmetry between practitioners’ values and their perception of their...
Chemokines, such as Stromal Derived Factor 1 (SDF-1 or CXCL12) and their G protein coupled receptors (GPCRs) are well known regulators of the development and functions of numerous tissues. CXCL12 has two receptors: CXCR4 and CXCR7 or atypical chemokine receptor 3 (ACKR3). CXCR7 has been described as an atypical “biased”...
Herpes simplex virus (HSV) is a ubiquitous human pathogen capable of causing debilitating diseases such as herpes stromal keratitis (HSK) and herpes simplex encephalitis (HSE). Although HSV infection initiates disease pathogenesis, the resulting clinical manifestations are attributed to immunopathological events that occur following viral clearance. To elucidate the molecular mechanisms...
Natural Killer (NK) cell dysfunction is associated with poorer clinical outcome in cancer patients. What regulates NK cell dysfunction in tumor microenvironment is not well understood. NKG2D/NKG2DL pathway is very well recognized as an effective immune axis in tumor immunosurveillance. Abundant evidence from experimental preclinical animal models as well as...
Cytokines made by macrophages play a critical role in determining the course of Legionella pneumophila infection. Prior, murine-based modeling indicated that the cytokine response initiated upon recognition of L. pneumophila involves a subset of Toll-like receptors, namely TLR2, TLR5, and TLR9. Using shRNA/siRNA knockdowns and subsequently CRISPR/Cas9 knockouts (KO), I...
Humans have a remarkable ability to create stable walking patterns that can resist and recover from perturbations. Unfortunately, this ability is substantially impaired after a stroke, limiting mobility and contributing to a high fall rate. To facilitate gait training during post-stroke rehabilitation, clinicians often incorporate body-weight support (BWS) systems that...
Superconducting circuits are electrical circuits fabricated from superconducting materials. Due to the engineered strong interactions and suppressed sensitivity to environmental noise, such systems hold substantial promise as quantum bits, in which quantum information can be stored and manipulated with high fidelity. Over the decades, great efforts have been devoted to...
In nearly all Eukaryotes, the membrane-enclosed nucleus contains the vast majority of the cellular genome. Within this sub-cellular compartment, the nuclear architecture facilitates genomic chromatin organization. Controlling chromosomal loci’s spatial positioning relative to subnuclear structures and each other can have local and global effects on gene expression. Moreover, chromatin organization...
Competitive gaming, or esports, is a high-skill endeavor embedded in a highly gendered social context. Using multiple methodological approaches, this dissertation argues that gender-gaming inequality is a result of changeable stereotypes that impact women throughout their lives. Specifically, gender-gaming stereotypes limit women’s initial access to gaming, discourage their continued interest...
We structure our lives around social groups – belonging to them and thinking about them. In this dissertation, I develop a new stereotype content measure to assess the attributes associated with groups in America today, propose and support a theory of sociocultural essentialism, and explore the strategic activation of sociocultural...
This dissertation argues that the nineteenth-century construction of “emotional susceptibility” turned a much-derided quirk of psychology—the long retention of one’s earliest affective impressions—into a basis for radical interventions into thinking about attachment, ethics, and the Victorian novel. I focus in particular on the work of Henry Mackenzie, Charlotte Brontë, George...
Over the past decade as smartphones and wearable tracking devices have grown in popularity, more individuals have begun collecting their own health and behavioral data. Innovations in sensor technology now allow individuals to continuously collect data over long periods of time with minimal effort. As a result, more data has...
This work examines important heterogeneous processes of organic molecules on surfaces, in the contexts of atmospheric and indoor environments. In large forest ecosystems, biogenic secondary organic aerosols (SOAs) constitute a dominant fraction of organic particulate matter in the atmosphere. The formation of SOAs starts from the emission of volatile organic...
Although research has shown LGBTQ+ youth are overrepresented in counts of homeless youth, scholars have yet to investigate whether this trend exists among adults experiencing homelessness. This dissertation uses an organizational analysis of four Chicago homeless centers that cater to young adults to argue that most LGBTQ+ youth are not...
Despite its demonstrated effectiveness, exposure therapy – repeatedly approaching a fear/anxiety trigger – is not widely used in the treatment of anxiety disorders. This may be due to its image as an aversive (and even harmful) approach to treatment and its reduced rates of compliance among patients. However, if exposure...
The prevalence of obesity within the US continues to rise, and many individuals elect to involve supportive others in their weight loss. Social support is generally helpful in weight management, but its mechanisms are less understood. One construct that deserves further attention is homophily, or the notion that “birds of...
The translation of proteins as effective intracellular drug candidates is limited by the challenge of cellular entry and their vulnerability to degradation. To advance their therapeutic potential, cell-impermeable proteins can be readily transformed into protein spherical nucleic acids (ProSNAs) or encapsulated into liposomal spherical nucleic acids (L-SNAs), structures defined by...
Recent developments in research concerning organic photovoltaics (OPVs) have overseen massive increases in device performance and the ascension of electron acceptor materials that outclass the preeminent acceptor compounds, buckminsterfullerene (C60) derivatives. New design strategies in the molecular structure of perylenediimides (PDIs) and fused-ring electron acceptors (FREAs) have increased single-junction photovoltaic...
In this thesis we study the geometric limits under degree growth of Julia sets and filled Julia sets for complex polynomials with a unique critical point at $z = 0$. Specifically, for $c \in \mathbb{S}^1$, we are interested in the limit of the associated sequence of Julia sets $J(f_{n,c})$ in...
Metal-organic frameworks are crystalline, nanoporous materials formed by metal nodes connected by organic ligands. MOFs represent an exciting approach to materials design where a material with desired properties can be made by choosing the compatible nodes, linkers and topologies independently. MOFs are highly porous and have high surface areas...
The use of light to understand detailed electronic structure and chemical properties of a molecule through light-matter interaction is fundamentally essential to design and analyze any chemical system. Over the past decades, rapid developments on optics and laser techniques improved the detection efficiency of multiphoton processes with more detailed chemical...