Index Catalog // Arch : Northwestern University Institutional Repository

Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy

Description:: Immune checkpoint inhibitors have not been effective for immunologically “cold” tumors, such as prostate cancer, which contain scarce tumor infiltrating lymphocytes. We hypothesized that select tissue-specific and immunostimulatory bacteria can potentiate these immunotherapies. Here we show that a patient-derived prostate-specific microbe, CP1, in combination with anti-PD-1 immunotherapy, increased survival and...
Keyword:: Cancer
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Jonathan Forrest Anker
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/22/2019
Date Modified:: 04/22/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

Characterization of Rare Genetic Variation in Polycystic Ovary Syndrome

Description:: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting approximately 1 in 10 reproductive-age women and remains the leading cause of female factor infertility among women of childbearing age. PCOS presents with features of hyperandrogenism, irregular menses and polycystic ovaries. Twin and family studies have demonstrated high heritability estimates...
Keyword:: lamin A/C, hyperandrogenism, anti-Mullerian hormone, genetic association, PCOS, and insulin receptor
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Lidija Kristina Gorsic
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/09/2019
Date Modified:: 04/09/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

Toxicity Mediated by Seed-Dependent Off-Target Effects in RNA Interference

Description:: Post-transcriptional gene silencing (PTGS) and, more specifically, RNA interference (RNAi) include the processes by which a small double-stranded RNA, 19 to 22 nucleotides (nts) long, negatively regulates the expression and/or translatability of a target RNA, which harbors reverse complementarity to that small RNA, by recruiting the so-called RNA-Induced Silencing Complex...
Keyword:: siRNA, RNA Interference, Cell Death, Cancer, shRNA, and DISE
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: William Edward Putzbach
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/01/2019
Date Modified:: 04/01/2019
Date Created:: 2018-01-01
Resource Type:: Dissertation

In Vitro Characterization of the Pseudomonas aeruginosa Cytotoxin ExoU

Description:: The Pseudomonas aeruginosa type III secretion system delivers effector proteins directly into target cells, allowing the bacterium to modulate host cell functions. ExoU is the most cytotoxic of the known effector proteins and has been associated with more severe infections in humans. Previous studies have shown that ExoU is a...
Keyword:: Pseudomonas aeruginosa, ExoU, and oligomerization
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Angelica Zhang
Owner:: Scholarly Digital Publishing
Date Uploaded:: 01/18/2019
Date Modified:: 01/18/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

Mitochondria Dictate Biological Outcomes in Malignancy, Regeneration and Immunity

Description:: The study of tumor metabolism from the middle of the 20th century through the early 21st almost entirely ignored the mitochondria; instead, the field focused on cancer cells use of glycolysis even when oxygen was not limiting, termed aerobic glycolysis. Due to this observation, it was often speculated that malignant...
Keyword:: Outcomes and Biological
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Samuel Edward Weinberg
Owner:: Scholarly Digital Publishing
Date Uploaded:: 01/16/2019
Date Modified:: 01/30/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

Rethinking the Biology of IL-33 Outside of Disease: Distinct Functions in Eosinophil Development and Microbiome Dysbiosis

Description:: Allergic diseases, including asthma, atopic dermatitis, and food allergy, are a widespread health issue. The prevalence of these diseases has been increasing, but the mechanism behind this increase and how allergies develop is not well understood. Although the immune system is central to the pathology of allergy, recent work has...
Keyword:: microbiome, eosinophils, ST2, IL-33, stem cells, and allergy
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Laura Katrina Ng Johnston
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/22/2018
Date Modified:: 01/29/2019
Date Created:: 2017-01-01
Resource Type:: Dissertation

Src Family Kinase Phosphorylation of the Motor Domain of the Human Kinesin-5, Eg5

Description:: Spindle formation in mammalian cells requires precise spatial and temporal regulation of the kinesin-5 motor proteins which generate outward force to establish spindle bipolarity. A growing body of work suggests that phosphorylation of kinesin-5 motor domains is an important regulator of their motor characteristics and function in cells. My thesis...
Keyword:: mitosis,, kinesin-5, cytoskeleton, phosphorylation, Src family kinases, and drug resistance
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Kathleen Gifford Bickel
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/12/2018
Date Modified:: 10/12/2018
Date Created:: 2017-01-01
Resource Type:: Dissertation

The MHC Ib Molecule Qa-1 Plays Multiple Roles in the Immune Response to Mycobacterium tuberculosis Infection

Description:: A number of nonclassical MHC Ib molecules recognizing distinct microbial antigens have been implicated in the immune response to Mycobacterium tuberculosis (Mtb). Due to the low polymorphism of MHC Ib molecules within the human population, these molecules and Mtb antigens are attractive targets for better vaccine development. Among these, HLA-E...
Keyword:: T cells and Mycobacterium tuberculosis
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Yao Bian
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/30/2018
Date Modified:: 04/30/2018
Date Created:: 2017-01-01
Resource Type:: Dissertation

Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-Induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells

Description:: The hormone prolactin (PRL) contributes to breast cancer pathogenesis through various signaling pathways, one of the most notable being the JAK2/signal transducer and activator of transcription 5 (STAT5) pathway. PRL-induced activation of the transcription factor STAT5 results in the upregulation of numerous genes implicated in breast cancer pathogenesis. However, the...
Keyword:: Transcription factor, HMGN, Histone H1, Chromatin, STAT5, and Prolactin
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Suzanne Marie Schauwecker
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/18/2018
Date Modified:: 04/18/2018
Date Created:: 2017-01-01
Resource Type:: Dissertation

Lipid Rafts and Acyl Protein Thioesterase in the protozoan parasite Trypanosoma brucei

Description:: The African trypanosome Trypanosoma brucei is a single-celled eukaryotic protozoan parasite with a single cilium/flagellum. It cycles between its mammalian host (bloodstream cell), in which it scavenges cholesterol, and its tsetse fly host (procyclic cell), in which it both scavenges cholesterol and synthesizes ergosterol. For the first part of the...
Keyword:: Lipid rafts, Sterols, Trypanosome, and Palmitoylation
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Aabha Sharma
Owner:: Scholarly Digital Publishing
Date Uploaded:: 03/28/2018
Date Modified:: 03/28/2018
Date Created:: 2017-01-01
Resource Type:: Dissertation

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Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy

Characterization of Rare Genetic Variation in Polycystic Ovary Syndrome

Toxicity Mediated by Seed-Dependent Off-Target Effects in RNA Interference

In Vitro Characterization of the Pseudomonas aeruginosa Cytotoxin ExoU

Mitochondria Dictate Biological Outcomes in Malignancy, Regeneration and Immunity

Rethinking the Biology of IL-33 Outside of Disease: Distinct Functions in Eosinophil Development and Microbiome Dysbiosis

Src Family Kinase Phosphorylation of the Motor Domain of the Human Kinesin-5, Eg5

The MHC Ib Molecule Qa-1 Plays Multiple Roles in the Immune Response to Mycobacterium tuberculosis Infection

Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-Induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells

Lipid Rafts and Acyl Protein Thioesterase in the protozoan parasite Trypanosoma brucei

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