From peacekeeping to telecommunication standards, the number, level of detail, and subject matter of international agreements have grown exponentially in recent decades. What are the consequences of the sheer complexity of international governance today? This symposium suggests a new framework to understand this proliferation of international accords: "international regime complexity."...
The European Coal and Steel Community (ECSC) was the first step in the process of European integration. Its founders had lofty aspirations that integration in the coal and steel would spill into a larger endeavor, and early scholarly analyses suggested that coal and steel integration was spurring more fundamental political...
This final report contains information on years 6-7-8 (2004-2007) of TEA-21 funded projects designated A487, W420, and A212. The report was submitted by Morris E. Fine and Semyon Vaynman in 2007.
PilD is an enzyme that processes prepilins that are part of the type II protein secretion apparatus and the type IV piliation machinery. Using a <em>Legionella pneumophila pilDlacZ</em> fusion strain to measure transcription, we observed a 20% increase in beta-galactosidase levels at 30°C vs. 37°C. At 25°C and 17°C vs....
Living organisms grow precisely controlled assemblies of inorganic crystals using organic substrates. This observation has inspired the strategy of using synthetic organic templates for the growth of tailored inorganic thin films. It has been previously shown that monomolecular organic layers floating on supersaturated aqueous subphases (Langmuir monolayers) select the structure...
In this thesis, we study routing and resource allocation problems which have probabilistic objective functions. This class of problems has received limited attention in literature despite its promising applications. A probabilistic objective function is capable of incorporating business targets into the problem modeling and representing the risk attitude of a...
Multiple Myeloma (MM) is an incurable plasma cell malignancy occurring within the bone marrow. Glucocorticoids (GCs) are widely used in the treatment of MM patients due to potent induction of apoptosis. Though known to occur via the glucocorticoid receptor (GR), the molecular details of GC-induced apoptosis in MM cells remain...
Oxide surface structures play a key role in many technological processes, including catalysis, thin film growth, and layered structures, and a thorough understanding of surface structures and surface structure dynamics is required in order to better engineer materials systems for these processes. This research works towards understanding these fundamental principles...
Motivated by applications to microfluidic separation systems like Capillary Electrophoresis (CE) and Capillary Electrochromatography (CEC), the research described in this dissertation analyzes through numerical and asymptotic methods the effect of variation in the wall zeta potential (or surface charge) on the electroosmotic flow field in a microchannel and the effect...
At the heart of nonlinear optimization methods lies the solution of linear systems of equations. As the size of the problem increases, it is imperative to use iterative methods, such as the conjugate gradient algorithm, to solve these linear systems. In the context of constrained optimization, it has proved to...