T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease, affecting children and adults. Chemotherapy regimens show high response rates but have debilitating effects and carry risk of relapse. Until now, no targeted therapy has been approved. In addition, 40% of patients will relapse and their treatment options are limited because...
Language models are the foundation of many natural language tasks such as machine translation, speech recognition, and dialogue systems. Modeling the probability distributions of text accurately helps capture the structures of language and extract valuable information contained in various corpora. In recent years, many advanced models have achieved state-of-the-art performance...
The logistics of policy implementation can lead to a delay from when the actual change in behavior occurs, leading to a shift in a time series. Using change point analysis allows for the data to determine where a change in mean, or other parameters, occurred. But when policy is implemented...
We live in an increasingly computational world; one that, in the near term, may require everyone to be computationally literate. Computer science (CS) education has greatly increased its reach in the last two decades with an increasing number of students having access to formal computer science classroom experiences in the...
Materials science has been central to human advancement since time immemorial. There has always been curiosity around studying the processes required to extract materials, examine their structure, and ultimately tailor their properties to meet human needs. Over the last few centuries, the ability to tailor material properties was driven by...
To be tempted is to be conflicted, but the conflict is not one of oscillation between two good options. Rather, it is normally easy to act on temptation and difficult to act against it. But this is puzzling, because unless temptation is a force that acts on us, it’s not...
Object Detection is a core computer vision problem and can facilitate many image understanding problems. Object Detection has witnessed significant progress in the past decade especially after deep learning is successfully applied to this field. Most of the detection models focus on generalizing the trained model to unseen samples of...
Engineering heat transport in materials is essential for thermal management in a wide range of technologies, from batteries to thermoelectrics. Materials host a wide spectrum of heat-carrying phonons, which vary in their frequency, spatial extent, and degree of plane-wave character. This diversity in phonon properties leads to complex behavior, especially...
In this dissertation, we aim to develop efficient algorithms with theoretical guarantees for several data-driven decision making problems. Specifically, we study the data-driven deci- sion making from three different perspectives: statistical learning, nonconvex optimization, and control of stochastic system. This dissertation contains three parts. In the first part, we study...
Nanocarriers as structures with at least one dimension in the nanometer scale are capable of loading small molecule therapeutics that would otherwise have poor bioavailability, non- specific uptake, and off target effects. Polymeric nanocarriers can be modified to tune their chemical and biological behavior to better suit the intended application....
The dissertation builds on my current research to demonstrate the connection between affect and learning through machine learning and qualitative analysis of interactions where players use a complex systems game. The project is threefold: First, I developed a thinking and learning intervention, the agent-based modeling simulation Ant Adaptation. I showed...
Abstract A significant component of the repetitive dynamics during locomotion in vertebrates is generated within the spinal cord. The legged locomotion of mammals is most likely controled by a hierarchical, multi-layer spinal network structure, while the axial circuitry generating the undulatory swimming motion of animals like lamprey is thought to...
This introductory chemistry textbook was compiled by Shelby Hatch at Northwestern University and is adapted from the following sources:
"Introductory Chemistry" by David W. Ball, The Saylor Foundation, Cleveland State University, is licensed
under CC BY-NC-SA 4.0 and is available at https://open.umn.edu/opentextbooks/textbooks/introductory-chemistry ; "Chemistry of Cooking" by Sorangel Rodriguez-Velazquez, American...
This data set was curated as part of an exercise for the LSSTC Data Science Fellowship Program (DSFP). The data are sourced from the Sloan Digital Sky Survey (SDSS; sdss.org).
The following query of the SDSS database was used to select these data (note - use of "TOP" in the...
This data set includes photometric features as measured by the Sloan Digital Sky Survey (SDSS; sdss.org) that can be used as a training set in a machine learning model to separate galaxies and stars. It is used as part of a problem developed for the LSSTC Data Science Fellowship Program....
These data are packaged as a "tarball" which includes main files. There are two main files:
training_sources.csv – list of sources in the training_lcs/ folder, including name, classification, mean mag, total number of observations, and duration of observations
test_sources.csv –list of sources in the test_lcs/ folder, including name, classification, mean...
A study to investigate the role of population sex ratio in gender switching in an A. Triphyllum population along with the role of different environmental factors and management activities on plant size and population sex ratio in two different populations
The ability of a cell to regulate its mechanical properties is central to its function. Emerging evidence suggests that interactions between the cell nucleus and cytoskeleton influence cell mechanics through poorly understood mechanisms. Here we conduct quantitative confocal imaging to show that loss of A-type lamins tends to increase nuclear...
Attitude control in quadrotor Unmanned Aerial Vehicle (UAV) systems is traditionally managed by optimal control loops tuned to minimize errors in performance. While robust, these loops perform sub-optimally in dynamic and unpredictable environments which inspire new interest in sophisticated solution and approaches such as reinforcement learning (RL) approaches which should...
Queer Velocities: Time, Sex, and Biopower on the Early Modern Stage explores how seventeenth-century French theater represents queer desire. In this book, the first queer theoretical treatment of canonical French theater, Jennifer Eun-Jung Row proposes that these velocities, moments of unseemly haste or strategic delay, sparked new kinds of attachments,... and This book is freely available in an open access edition thanks to TOME (Toward an Open Monograph Ecosystem)—a collaboration of the Association of American Universities, the Association of University Presses, and the Association of Research Libraries—and the generous support of the University of Minnesota. Learn more at the TOME website,...
On February 22, 2022, I gave a talk hosted by the African Studies Program of Georgetown University. Two days later, Russian battalions were sent across Ukraine’s borders by President Vladimir Putin. In real time, viewers around the world have seen immense distress unleashed on innocent citizens. In Africa, distress has...
This book is freely available in an open access edition thanks to TOME (Toward an Open Monograph Ecosystem)—a collaboration of the Association of American Universities, the Association of University Presses, and the Association of Research Libraries—and the generous support of Michigan State University. Learn more at the TOME website, available... and This book begins by tracing the history of naturalist fiction from the 1860s into the twentieth century and the reasons it spread around the world. Hill explores the development of three naturalist figures—the degenerate body, the self-liberated woman, and the social milieu—through close readings of fiction from France, Japan, and...
This book is freely available in an open access edition thanks to TOME (Toward an Open Monograph Ecosystem)—a collaboration of the Association of American Universities, the Association of University Presses, and the Association of Research Libraries—and the generous support of the University of Tennessee. Learn more at the TOME website,... and A century ago, activists confronting racism and colonialism—in India, South Africa, and Black America—used print media to connect with one another. Then, as now, the most effective medium for their undertakings was the English language. Imperfect Solidarities: Tagore, Gandhi, Du Bois, and the Global Anglophone tells the story of this...
This book is freely available in an open access edition thanks to TOME (Toward an Open Monograph Ecosystem)—a collaboration of the Association of American Universities, the Association of University Presses, and the Association of Research Libraries—and the generous support of the University of Tennessee. Learn more at the TOME website,... and Drawing on and responding to the writings of theorists such as Judith Butler, Sara Ahmed, Lauren Berlant, and Lisa Lowe, this book proposes the notion of “precarious intimacies” to navigate a dilemma: how to recognize, affirm, and value love, touch, and care while challenging the racialized and gendered politics in which...
Lichess is an online chess platform where players can play against each other in different rating brackets. Our idea was to visualize the chess opening hierarchy by experience level on the Lichess platform catered to beginner to advanced chess players. Chess openings are specific sequences of moves played by both...
In this video of simulated galaxy formation there are three panels, each showing the same scene from a different perspective. The leftmost is a view of interstellar gas, the coldest (blue) of which will eventually form into stars like the Sun. In the middle panel, which shows what the Hubble...
Different cancers are dependent on distinct genes for their survival. The Broad institute previously ran assays on cancer cell lines that knocked out individual genes. Cell survival was subsequently measured to discover what genes were most essential to cancer survival. This dashboard uses the “essentiality” scores produced from these assays...
My submission seeks to describe the consequences of the Russian invasion of Ukraine on civilians using recent data from the United Nations. However, my work acknowledges the fallibility and lack of granularity of data collected during armed conflict, as well as the tendency of quantification to dehumanize those it describes....
Cook County has high rate of vaccination across one of the largest populations in the country. But now that vaccine uptake is beginning to stagnate, what can Cook County do to close the gap? We used unsupervised learning to cluster Cook with 480 counties across the US, then used Tableau...