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- Description:
- Inter-organelle contact sites have become increasingly appreciated as important regulators of cellular homeostasis, and disruption of inter-organelle contact site dynamics and function has been observed in various pathologies. Recently, inter-organelle contact sites between mitochondria and lysosomes were discovered, offering a new mechanism by which these two organelles may directly interact,...
- Keyword:
- Calcium, Neurological Disease, Mitochondria, Lysosome, Contact Sites, and Imaging
- Subject:
- Medicine, Biology, and Neurosciences
- Creator:
- Peng, Wesley J
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15610 and etdadmin_upload_827420
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- Description:
- Atrial fibrillation (AF) is the most common cardiac arrhythmia, and associated with increased risk for ischemic stroke and mortality. While the risk of stroke has been shown to be reduced with the use of oral anticoagulants like Warfarin, these medications are predictably linked with an increased risk of bleeding, and...
- Keyword:
- Multidimensional imaging, Atrial fibrillation, Unicuspid aortic valves, Magnetic Resonance Imaging, Cardiac MRI, and 4D flow MRI
- Subject:
- Medical imaging, Engineering, and Biomedical engineering
- Creator:
- Ma, Liliana Esther
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15025 and etdadmin_upload_723481
-
- Description:
- Pathogenic bacteria scavenge essential nutrients including metals, amino acids and peptides to survive within the hostile host environment. Bacteria utilize ATP-binding cassette (ABC) transporters, powered by the energy of ATP hydrolysis, to move substrates across cellular membranes. The substrate-binding protein (SBP) shuttles substrate in the periplasm and directs the substrate...
- Keyword:
- ABC transporters, substrates, peptides, binding proteins, and heme
- Subject:
- Biology and Biophysics
- Creator:
- Tanaka, Kari J
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_640137 and http://dissertations.umi.com/northwestern:14534
-
- Description:
- Sound is one of the most important mediums to understand the environment around us. Identifying a sound event in prerecorded audio (such as a police siren, a dog bark, or a creaking door in soundscapes) leads to a better understanding of the context where the sound events occurred. To do...
- Keyword:
- Sound event detection, Machine learning, Human-in-the-loop interface, Sound event annotation, and Audio signal processing
- Subject:
- Computer science and Artificial intelligence
- Creator:
- Kim, Bongjun
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15064 and etdadmin_upload_739320
-
- Description:
- This dissertation investigates a number of models and algorithms in the context of optimization under uncertainty. The focus is on risk-averse optimization, where risk aversion is modeled via stochastic dominance, utility theory, and distributionally robust optimization. We first investigate an investment model with fixed contribution rates, optimize asset-allocation decisions in...
- Keyword:
- Distributionally robust optimization, Stochastic Programming, and Wasserstein distance
- Subject:
- Operations research
- Creator:
- Duque Villarreal, Daniel
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_763341 and http://dissertations.umi.com/northwestern:15241
-
- Description:
- Supported vanadium oxide materials have been extensively studied for alkane oxidative dehydrogenation (ODH) reactions due to their high activity and selectivity. The catalytic activity of supported VOx materials is influenced by the surface coverage of VOx sites and hence the distribution of V=O, V-O-V, and V-O-S (S, support) bonds. The...
- Keyword:
- heterogeneous catalysis, oxidative dehydrogenation, atomic layer deposition, and vanadium oxide
- Subject:
- Chemical engineering
- Creator:
- Samek, Izabela Anna
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14740 and etdadmin_upload_675097
-
- Description:
- Active lateral force feedback is essential for haptic applications in which forces on the fingertip is perpendicular to or in the same direction of finger movement, such as virtual shape rendering and button click rendering. In this thesis, I first present a novel device, the UltraShiver, that can provide large...
- Keyword:
- Active lateral force feedback, Ultrasonic oscillation, Localized control, Shape rendering, Button click rendering, and Electrostatic
- Subject:
- Mechanical engineering
- Creator:
- Xu, Heng
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15498 and etdadmin_upload_800297
-
- Description:
- In recent decades, mass loss from glaciers and ice caps (GICs) worldwide has accelerated, contributing significantly to the observed sea–level rise. Their continued melt is also expected to alter local hydrological systems, affecting freshwater availability and quality. Despite these problematic impacts, little is known about GIC variations prior to the...
- Keyword:
- Glaciers, Arctic, Holocene, and Ice caps
- Subject:
- Climate change, Geographic information science and geodesy, and Limnology
- Creator:
- Larocca, Laura Jennifer
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15847 and etdadmin_upload_861088
-
- Description:
- Increasingly high global energy consumption demands effective approaches to high energy efficiency and, at the same time, paths to reduced release of carbon dioxide, a primary greenhouse gas behind global climate change. Friction reduction is a vital aspect towards making energy systems more efficient and one of the most crucial...
- Keyword:
- tribology, wear, friction, and lubrication
- Subject:
- Mechanical engineering and Materials Science
- Creator:
- Khan, Arman Mohammad
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15582 and etdadmin_upload_819626
-
- Description:
- The investigation of ceria-related materials has a long history since 1920s. The first publication on web of science traces back to 1928. Ever since that, more studies come out and surge starting from 1987. This material has attracted extensive attention due to its wide applications in electrochemical devices, catalysis, and...
- Keyword:
- oxygen vacancy, ceria, redox kinetics, thermochemical fuel production, zirconium, and catalysis
- Subject:
- Materials Science
- Creator:
- Yuan, Weizi
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15180 and etdadmin_upload_753575