Voltage-gated potassium (KV) currents play a crucial role in shaping and controlling the firing patterns that serve as the fundamental basis for the differential signal processing from the ear to the auditory cortex, with distinct firing patterns observed with high- and low-frequency phenotypes. This is an interesting phenomenon, in the...
Lackluster BA completion rates have made it clear that improving postsecondary outcomes in the U.S. is not simply a matter of raising college enrollment rates. In addition to increasing the number of people who attend college, it is also important to increase the number of people who graduate. Over the...
Tailoring the design of surfaces and interfaces with nanoscale features has the ability to significantly impact biological functions for a swath of applications including drug delivery, structure assembly, and biomedicine. For example, creating spatially defined nanoscale patterns has been known to contribute to changes in cellular architecture and mechanical properties,...
The Ohio River Valley was the site of an intense rivalry between Protestants and Catholics in the nineteenth century, as members of each group vied to extend their control through the development of churches, schools, orphanages, and other institutions. This dissertation explores the process and analyzes the effects of Catholic...
Popular histories of United States mass incarceration often focus on federal wars on crime, law and order policing, and the passage of harsh sentencing laws to explain how the United States transformed into the world’s leader in incarceration. My dissertation on the crisis of state prison overcrowding and prisoner resistance...
In this thesis, we discuss classical and recent results around the damped wave equation on compact and noncompact manifolds. We firstly show that on asymptotically cylindrical and conic manifolds, the geometric control condition and the network control condition give exponential and logarithmic decay rates respectively. We then show that a...
Stimulation of the cGAS-STING (cycle GMP-AMP synthase-Stimulator of Interferon Genes) pathway increases T cell activation and tracking into the tumor and reverses the immunosuppressive phenotype of myeloid cells. Direct targeting of the STING receptor using synthetic cyclic dinucleotide (CDN) ligands represents an attractive immunotherapeutic strategy for the treatment of lymphocyte-depleted...
Political theorists generally ascribe to the state a decisive role in the formation and protection of property rights, a view especially prevalent in the historiography of financial property in the United States. Given the capacities of government at the American Founding, however, such accounts are implausible. Drawing on writings composed...
Recent developments have enabled L12-strengthened Co-based superalloys, which have thepotential to surpass Ni-based superalloys as the material of choice for the hottest sections of turbine
blades due to cobalt’s 40 ºC higher melting point. The most-studied branch of Co-based
superalloys are based on the L12 phase Co3(Al,W); however, there is...
Caught between world wars and Stalin’s consolidation of power, citizens of Soviet Russia of the 1920s and 1930s had little to laugh about. Yet a unique tendency toward disruptive humor surfaces in poetry and prose over these two decades. I explore disruptive humor in select longer poetry of Nikolai Zabolotsky,...
This dissertation consists of three chapters about education policies in developing countries. The first chapter examines two extrapolation approaches to make out-of-sample predictions using cash transfer experiments in Malawi and Morocco. The second chapter evaluates India's workfare program in terms of targeting efficiency and effects on school enrollment, in comparison...
We present both semiclassical asymptotics for the wave equation on a stationary Kaluza-Klein spacetime and an index theorem describing the difference of the positive-frequency
spectral projectors for two stationary regions in a globally hyperbolic spacetime. The
first result involves analyzing the restrictions of the wave trace to isotypic subspaces for...
This dissertation focuses on two topics in international macroeconomics: the identification of the international spillovers of US interest rate shocks, and the study of its main transmission channels. In Chapter 1, I present the Spillover Puzzle of US Monetary Policy - the fact that in response to a US interest...
Chapter 1 investigates asks the question how do financial frictions affect the type of human capital investments that students make in college? To study this question, I build a novel dataset covering more than 700,000 U.S. students, merging commencement records with address histories, credit bureau records, and professional resumes. I...
From daily hygiene habits, such as brushing teeth, to the ingestion of pharmaceuticals, many forms of healthcare are commonly practiced in daily life, at home. How have household healthcare practices changed over time in urban America? Taking Washington, DC as my case study, I examine patterns of household pharmaceuticals access...
This dissertation aims to understand how Black Chicagoans work with institutions and neighbors they distrust to pursue common policy goals – in this case, to remedy state and community violence. I introduce the theory of distrustful cooperation. Using three Chicago neighborhoods as cased studies: Greater Englewood, Bronzeville, and Calumet Heights,...
Motor abnormalities (e.g., dyskinesia, psychomotor slowing, neurological soft signs) are core features of schizophrenia observed from the premorbid period through chronic illness, suggesting motor dysfunction may reflect the pathophysiology of psychosis. Among this list of motor abnormalities, psychomotor slowing in particular is one of the most consistently observed and robust...
Atomistic methods offer a powerful set of tools in the study of materials systems, as they allow materials scientists to ask questions with a high degree of specificity. They are well suited for studying and designing energy materials, critical due to the climate crisis, in part due to their ability...
The importance of understanding indoor microbial exposure is increasingly recognized, particularly concerning the emergence of pathogens and antimicrobial resistance. With the advancements of sequencing technologies, our capability of exploring indoor microbial communities has dramatically increased. However, huge challenges remain to translate sequence-based knowledge to actionable interpretations to support human health...
Every music theorist has their own personal reasons for engaging in the craft of theorizing about music. Many discover that there is something special about a theoretic disposition which differs from other sorts of interactions with music. It is often this special something that draws musicians into the discipline: specifically,...
This dissertation explores the economics of health and housing policies. In the first chapter, I discuss information disclosure policies in healthcare. Information disclosure programs can help consumers make better choices, but the consumers who respond the most to the information may not benefit the most or generate the most savings...
Heteroanionic materials are a class of materials of interest for their unique and tunable electronic, ionic, thermal, and optical properties, which are distinct from their homoanionic counterparts due to their multi-anionic nature. Oxynitrides, a type of heteroanionic material, are useful catalysts due to the effect of mixing oxygen and nitrogen...
Astronomy has entered a “multimessenger” era: one that combines electromagnetic “sight” with gravitational “touch.” This dissertation serves as a roadmap of the multimessenger frontier, to join the littered environments of dead and dying starswith their unclear origins. To uncover stars’ innermost secrets, we explore rare, transient glimpses into single, double,...
Very few studies have examined school racial climate in racially diverse school contexts. School racial climate refers to “perceptions of interracial interactions and the socialization around race and culture in a school” (Byrd, 2017, p. 700). The association between interracial peer interactions, psychological well-being, and academic outcomes is well documented,...
This dissertation comprises three essays in distinct areas of economic theory, yet all are related to experimentation and learning. In the first chapter, I study how organizations assign tasks to identify the best candidate to promote among a pool of workers. Task allocation and workers’ motivation interact through the organization’s...
Systems of accountability for police who violate the U.S. Constitution are broken. Among other mechanisms of accountability, the judicial system should provide a path for victims to obtain a remedy when their constitutional rights are violated. Yet unless the law is clearly established beyond debate, the doctrine of qualified immunity...
Bio-integrated electronics with advanced monitoring capabilities have garnered considerable interest as a means of expanding patient care beyond traditional hospital and clinic settings. These mechanically soft microsystems, many of which are bioresorbable and wireless, have the potential to replace bulky, rigid, and wired medical technologies by matching or exceeding their...
This dissertation explores accounting information's role in forming R\&D alliances and subsequent innovation. Specifically, I utilize the effect of the recent revenue recognition rule change, Accounting Standard Codification (ASC) 606, on drug development firms. ASC 606 allows managers to change revenue recognition timing and increases disclosure requirements. I first document...
``Hazy decisions: The effect of dementia on medical decision-making'' \\ I estimate the causal effect of having dementia on the course of treatment for unrelated diseases by leveraging differences in the relative time of onset of dementia and the other condition in a difference-in-differences event-study framework. To demonstrate this approach...
Lithium-ion battery technology is a critically important component of the emerging renewable energy infrastructure. Since battery technology was first commercialized in the 1990s, significant progress has been made in materials development, motivated by the prospect of higher energy and power densities, increased cycling longevity, and faster charging and discharging rates....
Every day, we communicate through computers on projects ranging from a group lunch order to booking a flight to learning critical medical information. And every day, we also miscommunicate through computers: We don’t pick up on an intentionally humorous response, or we miss the criticality of a request. This is...
SCN2A encodes the NaV1.2 voltage-gated sodium channel, which is thought to contribute to the development of the central nervous system. Pathogenic variants in SCN2A have been associated with neurodevelopmental disorders (NDD), including developmental and epileptic encephalopathies (DEE), intellectual disability (ID), and autism spectrum disorder (ASD). These disorders represent a significant...
The speed of the storage device has long lagged behind the computation speed of processors.As a result, the I/O performance of storage systems in a supercomputer fails to keep up with its computational power.
This gap continues to widen in modern supercomputers.
On future exascale supercomputers, this issue can worsen...
Visual processing often requires the coordination of different neurophysiological regions in the visual system to independently represent and then re-integrate the different features of an object to gain an accurate and coherent representation of that object. Yet, under certain circumstances, this process can go awry and result in illusory misbindings,...
The basal ganglia operate largely in closed parallel loops, including an associative circuit for goal-directed behavior originating from the dorsomedial striatum (DMS) and a somatosensory circuit important for habit formation originating from the dorsolateral striatum (DLS). An exception to this parallel circuit organization was proposed to explain how information is...
This dissertation consists of three chapters on theoretical and empirical industrial organization. The first chapter highlights a previously unnoticed property of commonlyused discrete choice models, which is that they feature parallel demand curves. The second chapter studies how a behavioral consumer preference with “price reference effect” can overturn the standard...
This dissertation is a collection of three studies on topics in economic history and labor economics, in the United States. In the first chapter, I investigate the relationship between temporary paternal absence and long-term labor market outcomes. Specifically, I exploit the natural experiment of fathers’ WWII conscription, combined with longitudinal...
Simple sensorimotor tasks, such as lifting a cup or balancing a tray, requires not only controlled motor output, but also the ability to accurately perceive sensory information. After a hemiparetic stroke, individuals often experience sensory deficits in addition to motor impairments. However, research on the extent of changes in sensory...
As more thermoelectric materials/devices make it into the market for various applications, severalaspects need to be explored and optimized, beyond simply targeting high conversion efficiency at
the material levels. One critical aspect is the guarantee of mechanical stability at both the material
and the device level, which demands deeper understanding...
The potential association between Female Genital Mutilation (FGM) and the incidence of Human Immunodeficiency Virus (HIV) has been a part of academic discourse for three decades. By considering the mixed reports on the association between FGM and HIV so far, this dissertation contributes to the current state of research by...
This dissertation considers how women’s spectatorship—how women are imagined as viewing subjects, and what are defined as feminine ways of watching—is transformed by digital technologies, and what it reveals about the shifting nature of privacy and visibility. It maps the contours of our current configuration of gendered looking relations by...
Machine learning is seeping into every fabric in various practical domains such as autonomous driving, wearable computing, and smart buildings. However, in the actual development and integration, especially when the learning-based components are frequently included as components of large complex systems where the physical instances can be included as interactable...
As polymer science has advanced as a field, so too have the uses for polymeric materials. We encounter polymers and plastics on a daily basis, and while their presence has greatly improved our quality of life, they have also had a profound and often negative impact on our environment. Plastic...
Task-oriented conversational systems are becoming increasingly popular, as shown by the rise of conversational recommendation systems across multiple platforms (e.g., Google Home, Alexa, and Siri) and domains (e.g., local establishments, e-commerce, books, music, and movies). However, users are still largely limited in what preferences they can express and how, as...
Increasingly, governments contract with private firms to provide publicly funded or subsidized goods and services, ranging from defense contracts, social insurance programs to small business loans. In such publicly funded, privately provided markets, governments set specific rules and policies to allow efficient provision or allocation of goods and services. Given...
Russia and Turkey occupy a significant portion of current global news as the rest of the world analyzes the trajectories of these countries. Most scholars focus on the socio-political landscapes of the two while disregarding cultural and literary studies. Such a top-down approach fails to consider the profound identity crises...
The physical structure of chromatin has recently emerged as a key contributor to genome regulation and cellular function. Chromatin packing dictates the conformation of the 2-meter-long DNA polymer within the ~10 μm cell nucleus. This conformation can influence gene function by regulating the accessibility of molecular regulators to DNA, altering...
Pediatric high-grade gliomas (pHGGs) are aggressive pediatric CNS tumors and an important subset are characterized by mutations in H3F3A, the gene that encodes Histone H3.3 (H3.3). Substitution of Glycine at position 34 of H3.3 with either Arginine or Valine (H3.3G34R/V), was recently described and characterized in a large cohort...
In this thesis, we consider the categories of sheaves with singular support on certain Lagrangians and the categories of microlocal sheaves with support on certain Lagrangians obtained by microlocalization, and study properties of functors between these categories.First, we study one class of the microlocal restriction functor for open inclusions, namely...
In my dissertation, I explore the connection between economic history and political economy in three ways.Chapter 1, studies the effects of a postal program in the U.S. at the turn of the 20th century and its role in increasing access to higher education. Chapter 2, co-authored with Alexey Makaring and...
Social networks play a crucial role in developing economies. One of their most important functions is facilitating the flow of information, particularly about the efficacy of new technologies. This dissertation explores three aspects of this research agenda. First, I study how economists can estimate the structure of a social network...
In this paper, I analyze a piece of music that I wrote called The Health, a 90-minute musical ceremony that comprises speech, action, video projections, costumes, lights, chant, song, recomposed hold music, diagnostic exams, and renaissance magic. I wrote the piece for Mocrep and myself to perform, the initial run...
This dissertation reconstructs North and South Carolina Lowcountry plantation waterfronts as a means of better understanding mobility, inequality, and human-environment interactions in the antebellum Lowcountry. Using a theoretical framework of hydrosociality, the author undertook archaeological and archival research to investigate the question: how did the built environment of navigable waterways...
Colloidal crystals engineered with DNA are fascinating structures that constitute an emerging form of programmable matter. Indeed, the use of DNA as a programmable bond has led to thousands of new crystal types, with exquisite control over crystal symmetry and lattice parameters. However, synthesizing large (> 100 µm) single-crystals has...
In the United States, those who have lower income, education level, and occupational prestige, are more likely to develop, have worse symptoms of, and die from a wide range of chronic diseases. This phenomenon prompted much research trying to delineate the underlying pathways, and inflammation has been highlighted as a...
This dissertation has three chapters. Chapter one evaluates the effects of Short-Time Workin Germany during the great financial crisis. Chapter two describes how British inventors
during the industrial revolution worked on more central technologies. This in turn resulted
in faster growth. Chapter three builds on a novel patent data set...
Deduplication, also referred to as "entity resolution", is a common and crucial pre-processing step in the construction of social networks. Traditional deduplication methods compare the attributes (such as name and age) of potential matching pairs to estimate a match probability for a pair. Recently research has used clustering techniques for...
How do exporting firms react to changes in the cost of credit? To answer this question, we exploit an exogenous variation in banking regulation which increases the cost of financ- ing for exports in the European Union. Using a unique dataset which combines customs, firm-level, and credit registry data on...
Over the past decade the market for children’s digital play activities focused on science, technology, engineering, and mathematics (STEM) has grown exponentially. One benefit to the growth in digital STEM play is that it can provide children opportunities to engage the cognitive skills and practices that can be valuable for...
Different features of the visual world are conveyed to the retino-recipient regions of the brain by more than 40 types of retinal ganglion cells (RGCS). Feature detection by RGCs depends on a combination of intrinsic and morphological properties where the interplay of excitatory and inhibitory inputs occurs through local retinal...
Meiosis is a specialized form of cell division that gives rise to haploid reproductive cells by replicating the genetic material once and undergoing two rounds of partitioning. While most forms of cell division require centrosomes to assemble a bipolar microtubule-based spindle that segregates chromosomes, female gametes (oocytes) are unique in...
As opposed to the nanoscale deposition techniques often used for material syntheses, here, I focus on mesoscale material depositions and how to design interfaces to efficiently manage such deposition and potential accumulation. These deposition processes include condensation, condensation frosting, particle capture, and vaporization. Through the lens of energy and sustainability,...
Mindfulness is the dynamic process of building and maintaining awareness of one’s environment and paying attention to stimuli (Langer, 1989; Brown, Ryan, & Creswell, 2007). A cognitively effortful endeavor, mindfulness requires “the capacity to respond to unanticipated cues or signals from one’s context” (Levinthal & Rerup, 2006, p. 504). Mindful...
This thesis focuses on exploring the explanatory and discovery potential of the four-neutrino and enhanced neutrino magnetic and electric dipole moments hypotheses when
applied to the NOvA/T2K discrepancy and the XENON1T anomaly, respectively. Firstly,
we study the effect of a very light (sub eV) sterile neutrino on the NOvA/T2K anom-...
Recommender systems (RSs) have become essential tools that provide personalized recommendations to their users. These systems may consider user, item provider, and system requirements simultaneously. With the inclusion of possibly clashing considerations, there is a growing focus on solving multiple-objective recommender system (MORS) problems as efficiently as possible. The constrained...
We establish the criterion for chaos in three-planet systems, for systems similar to those discovered by the Kepler spacecraft. Our main results are as follows: (i) The simplest criterion, which is based on overlapping mean motion resonances (MMRs), only agrees with numerical simulations at a very crude level. (ii) Much...
A great deal of work has been done in recent years to construct algebraic invariants ofLegendrian knots, and their higher-dimensional analogues. Here we employ the diagram-
matic calculus developed in [3], in order to develop an iterative method for computing the
so-called vexillary functions of a class of Legendrian surfaces....
Autism spectrum disorder (ASD) and intellectual disability (ID) are two of the most highly prevalent neurodevelopmental disorders (NDDs), each affecting roughly 2% of the population. Despite the need for therapies, few exist due to a myriad of challenges, such as the complex underlying genetic etiology and historic inaccessibility of neural...
The production and spread of digital news involves a wide range of actors: journalists and the organizations that employ them, social media platforms, audiences, and myriad commentators, citizen journalists, bloggers, and other actors who contribute to the news ecosystem without inhabiting an official role. These actors interact in flexible, often...
This dissertation presents an affect-centered approach to the analysis and interpretation of the experience of music and its attendant meaning in selected works of literature and cinema. Music’s interpretative mutability often charges it with meaning, though in infinite gradations of singularity rather than any universal sense. Rather than undertake a...
Vertebrate brains evolved to facilitate a diverse array of behaviors and internal cognitive processes. Theories of neural function have proposed that neural computation is organized within populations or ensembles of neurons. Here, we identify ensembles of neurons in the striatum, the main input nucleus of the basal ganglia, in which...
This dissertation studies three markets with regulated prices. I focus on how these regulations shape the behavior of firms along non-price dimensions. Chapter 1 studies the effects of community rating regulations in the US individual health insurance exchange market. In this market, the Affordable Care Act established community rating areas...
The dissertation project considers the generative possibilities to envision Black subjectivity that emerges from a sustained consideration of different forms of difficult racial and sexual intimacies. The artists whose work is engaged throughout the project, Leasho Johnson, Ajamu X, and NIC Kay recognize that to be Black is to always...
Chapter 1. Caste, Bureaucracy, and the Limits to Political Affirmative Action. The aim of political affirmative action policies is to ensure that disadvantaged groups are represented in their governments and, in turn, that laws preferred by this group are more likely to be instituted. Often, however, they have not been...
Human olfactory function is important for a myriad of behaviors, including food seeking, social cognition, memory, emotional regulation, and detecting environmental threats. In animal models, particularly dense olfactory inputs have been shown to target orbitofrontal cortex (OFC), a region involved in multimodal sensory integration, reward coding, and flexibly guiding our...
In the first part of the thesis we,given a dg-Lie algebra $\g$, a commutative
dg-algebra $A$ and a twisting cochain $\mu$ in
$A \otimes \g$, we construct a map
from the functor of curved deformations of $\g$ to the
functor of curved deformations of the twisted tensor product
$A \otimes_\mu...
Neuroblastoma is one of the most common childhood cancers with one of the lowest survival rates, accounting for 15% of childhood cancer mortality. Approximately 15% of patients do not respond to initial treatment, and about half of children treated for high-risk neuroblastoma will relapse following remission. Ionizing radiation has long...
Amyloid beta oligomers (AβOs) are a key instigator of neurodegeneration in Alzheimer’s disease (AD). The work presented in this thesis includes three disease-modifying approaches to disrupt pathological AβO-related mechanisms in AD: (1) inhibiting AβO buildup, (2) blocking AβO-induced tau phosphorylation, and (3) neutralizing AβOs. These three approaches were tested in...
Technology that processes text, audio and video, as well as location data, has revolutionized many industries by enabling innovative operations for customer retention. To retain transactions for a platform and viewers for advertisers, this dissertation leverages novel digital tools to analyze consumer behavior, proposes original economic frameworks to guide platform...
The on-going demand for miniaturized optical and on-chip photonic systems of the future has led to a few potential solutions in the literature. Recent advances in van der Waals and 2-dimensional materials signal a bright future for the next generation, compact electronic and photonic devices. With reduced dimensionality and material...
Human communication has become increasingly reliant on systems made and managed by large technology companies like Google, Apple, Twitter, and Meta (formerly Facebook). These systems offer people many benefits, but they also present new challenges for society. In recent years, researchers, lawmakers, and journalists have suggested that large technology companies...
The retina detects light, processes the visual signal, and sends a complex set of parallel information channels to the brain via a functionally diverse set of retinal ganglion cells types. This manuscript examines these retinal ganglion cell types, the visual features they encode, and the computational mechanisms leading to their...
The esophagus plays a crucial role in the functioning of the gastrointestinal tract and esophageal disorders are associated with reduced quality of life. Several studies have reported that there is a high worldwide prevalence of esophageal disorders. Esophageal disorders are related to the mechanical properties and function of the esophageal...
Nanomaterials present an exciting landscape of innovation at length scales below 100 nm, wherein controllable synthesis and materials metrology have led to tunable structure-property relationships and next-generation products. The disruptive field of nanotechnology is poised to capitalize upon the exotic chemistry and physics of these nanomaterials to enable more efficient...
In Chapter 1, I analyze optimal capital structure using a model in which firms issue securities in order to (1) finance investments in operations and (2) recapitalize the firm. In this trade-off model, firms balance the tax benefits of debt against the costs of financial distress. Key to the analysis,...
As the technology enabling touch-sense rendering of virtual textures grows in efficacy and prevalence, so too grows the need for a standardized means of storing, transferring, and reconstituting textural signals. Furthermore, to achieve the ultra-low-latency requirements of the next generation of global communications networks, this digital texture representation must be...
In this essay I examine George Aperghis’ process-based compositional thought in the score and performance practice of Retrouvailles, with a focus on the non-hierarchical and simultaneous use of interdisciplinary elements. I demonstrate how Aperghis sets up the complex dramaturgy of superimposed, suggestive narratives in this work as a case-study of...
The purpose of this thesis is to study the empirical measure of the t-distributed stochastic neighbor embedding algorithm (t-SNE) when the input is given by n independent, identically distributed inputs.We show that this sequence of measures converges to an equilibrium measure, which can be described as the solution of a...
Relative to individual level exposures (such as childhood trauma, life events, and bullying exposure), contextual or systems level environmental factors have received relatively less attention in the psychology literature. While landmark epidemiological and sociological studies have uncovered key insights with regards to systems, this knowledge has not often been translated...
This dissertation is an in-depth exploration of Clarke Distributions (for 10), an original musical composition based on the use of text to establish interrelational listening and performance patterns between performers, in place of any fixed musical material. Inspired by research into improvisation, cognition, aesthetics, and linguistics, these patterns manifest as...
The societies of the former Yugoslavia are only a quarter-century removed from extensive warfare, yet collectively represent one of the fastest-growing tourism destinations in the world. This dissertation employs a global and relational lens to examine how contested narratives of recent conflict history are marketed, performed, and narrativized in settings...
This thesis explores the potential of two-dimensional (2D) or van der Waals (vdW) materials for printed optoelectronic devices. The research focuses on the development of processing, imaging, and modeling of materials and thin-film devices to optimize performance and introduce novel properties. A gate-dependent resistor network model is presented that establishes...
Much of our understanding of human becoming and the process by which possible futures are developed has been based on narrow samples of human experience, which are usually more privileged and provide a narrow view of variability in human life and development. The developmental and educational pathways of minoritized young...
This dissertation introduces several novel computational imaging techniques that capture and analyze the 3D surface shapes and internal layered materials. The research proposes user-friendly and non-invasive imaging systems, constructed using only commercial off-the-shelf (COTS) components, which provide accurate measurement of 3D information that was previously inaccessible. The dissertation focuses on...
Soft materials are inherently fluxional, with morphologies and behaviors that are dictated by their solvation state. Thus, many organic systems cannot be reliably imaged by static dry state or cryogenic-transmission electron microscopy (TEM). This motivated us to pursue liquid cell (LC) TEM method development to study our own materials and...
CD95/Fas ligand (CD95L) is a well characterized activator of extrinsic apoptosis. CD95L protein binds to its cognate receptor, CD95/Fas/APO-1, inducing apoptotic signaling in sensitive cells. However, expression of CD95L is toxic even in the absence of CD95. We previously reported that the CD95L open reading frame (ORF) is enriched for...
Involuntary motor activities such as spasms arise from hyperreflexia in about 70% of individuals with spinal cord injuries (SCI). Despite this prevalence and the negative impact on health and safety, it is unclear what determines the severity of the spasms that develop. This study investigated the impact of injury severity...
Uranium is a unique, multifaceted element that possesses rich chemistry and promise for challenging reactions. Pressing demands within nuclear stockpile stewardship and the nuclear energy sector call for development of this relatively understudied element. Uranium metal–organic frameworks (U-MOFs), a class of nanoscale hybrid materials, harness the exceptional attributes of uranium...
In the 1960s, the International Theatre Institute (ITI), the organization sponsored by the United Nations Educational, Scientific and Cultural Organization (UNESCO) with a mission to represents the world’s theaters, was faced with a crisis of representation. After twenty years of existence, the institution had not succeeded in substantially expanding beyond...
Monetary Policy plays a crucial role in modern economies by supporting price, financial and economic stability. Its efficacy, however, exhibits variation both over time and across space leading to partially unpredictable and inconsistent outcomes. This thesis shows that the variation in the efficacy of monetary policy crucially relates to the...