The study of tumor metabolism from the middle of the 20th century through the early 21st almost entirely ignored the mitochondria; instead, the field focused on cancer cells use of glycolysis even when oxygen was not limiting, termed aerobic glycolysis. Due to this observation, it was often speculated that malignant...
This dissertation explores a form of performance I call “ototheatre,” which is a mobile and participatory audience experience executed with portable sound technology. Ototheatre is an emergent artistic form that sits at a convergence of contemporary technologies and audience consumption habits. Case studies, including smartphone applications and new theatrical works...
My research interests, which span organic, inorganic, physical and biochemistry, have focused broadly on photo-, magneto- and redox-active molecules, especially those with potential applications in organic photovoltaics, spintronics and electronics. My research under the joint supervision of Professor Wasielewski and Professor Fraser Stoddart has concentrated upon understanding electronic and magnetic...
In his Nobel lecture Herbert Kroemer famously stated that “The interface is the device”. While he made this statement in the context of semiconducting heterostructures, it has proven to be just as relevant for more complex materials, such as the transition metal oxides. In particular, the 2-D conducting gas that...
In vivo, substantia nigra pars compacta (SNc) dopaminergic neurons exhibit three spiking patterns – irregular, regular, and bursting. These distinct modes of activity are thought to underlie the different roles that dopamine (DA) plays in target structures within the basal ganglia. In particular, burst spiking in SNc DA neurons is...
The promise of next-generation electronics, which combines features such as mechanical flexibility, optical transparency, and relatively low-cost, has stimulated tremendous research efforts during the past few years. As perhaps the most fundamental component of an electronic circuit, the design and optimization of the thin film transistor (TFT) is of great...
Some five years ago, during the first year of my assistantship at the Music Academy in Katowice, I required students to analyse some of Penderecki's early, so-called "sonoristic" pieces. The outcome of that assignment proved unsatisfactory, however, because the students tended to describe Penderecki's pieces as chaotic assemblages of sound...
In the near future, self-driving or driverless vehicles will operate without human control, enabling passengers to use their time in new ways. This opens up avenues for designing new interactions and experiences for individuals or groups traveling in an automobile. For that scenario, automobile manufacturers propose developing bigger and better...
Photovoltaic technology can help meet the exploding world energy demand in a sustainable and environmentally friendly way. Organic photovoltaics (OPVs) are especially attractive because they can be constructed with low-cost organic content and are amenable to high-throughput large-scale fabrication techniques. Synthetic modification of organic semiconductors has paved way for the...
The Pseudomonas aeruginosa type III secretion system delivers effector proteins directly into target cells, allowing the bacterium to modulate host cell functions. ExoU is the most cytotoxic of the known effector proteins and has been associated with more severe infections in humans. Previous studies have shown that ExoU is a...
Most lubricants contain a series of additives that reduce friction and wear, and protect contacting surfaces. The design of these additives must be modernized to meet the challenges involved with high operating temperatures, extreme environmental conditions, and increasingly stringent environmental regulations. This research demonstrates three novel lubricant additive strategies that...
This dissertation asks how a dynamic of vengeance involving the United States and anti-imperialist political organizations in the Middle East emerged and persisted between the 1967 Middle East war and the battle of Tora Bora in Afghanistan in December 2001. It tracks the construction of channels—ideological, institutional, emotional, and personal—through...
Of the thousands of planetary candidates discovered by the Kepler mission, roughly a third are in known multiple transiting-planet systems. High-multiplicity Kepler systems (referred to as Kepler Multis) are often tightly packed and may be on the verge of instability. Many systems of this type could have experienced past instabilities,...
The Bcl-2 family is considered the guardian of the mitochondrial apoptotic pathway. While there are numerous endogenous Bcl-2 antagonists that share similar homology, structure, topology, and expression pattern, only the loss of Bim in mice is sufficient to lead to the development of a systemic autoimmunity. Even loss of both...
Many species have lost their natural habitat due to anthropogenic land use change. Ecologists are increasingly looking at habitat in cities to bolster efforts to conserve biodiversity. Green roofs are examples of urban habitats that are becoming more common globally. Green roofs can provide resources to support life in an...
Psychosocial stress is part of everyday life, and while ubiquitous, stress plays a huge role disease development and treatment. Though the stressor’s intensity, predictability, and frequency (acute vs chronic) are important determinants of disease development, interactions with one’s genetic and epigenetic make-up also play a causal role. Major Depressive Disorder...
Eosinophils are major effector cells in diseases including asthma, rhinitis, certain gastrointestinal disorders and atopic dermatitis. Current treatments include mediator antagonists and anti-inflammatory drugs that reduce allergic cell numbers and inhibit mediator release, but they are not fully effective or curative. On their surface, eosinophils selectively express Siglec-8 (sialic acid-binding...
The expanding use of nanomaterials in consumer products challenges scientists to understand the impact of these materials before their inevitable release into the environment. In the same way that the widespread use of DDT and asbestos has caused unforeseen negative impacts on both the environment and on human health, the...
In the past few years, educators have been pushing for an integration of the arts into science, technology, engineering, and math (STEM) learning to promote innovation and creativity in these fields. The present study explores the relation between creativity and STEM learning among young children in digital and non-digital contexts,...
Metabolic conditions affect the developmental tempo of most animal species. Consequently, developmental gene regulatory networks (GRNs) must faithfully adjust their dynamics to a variable time scale. We find evidence that weak repressors of gene expression provide the necessary coupling between GRN output and cellular metabolism. Using a mathematical model that...
Many stroke survivors are left with residual movement impairments. Treating these impairments has proven difficult, because it is often unclear which mechanisms drive movement impairment. While the exact mechanisms are still uncertain, at present, evidence suggests that neuromuscular function is disrupted in two key domains following stroke: muscle biomechanics, and...
The rodent whisker system is a widely used model to study the sense of touch. Its neuroanatomy parallels that of the human, but its mechanics are vastly simplified compared to that of the human tactile system. Just like other modalities with complex sensor accessory structures, the geometry, mechanics, and material...
This dissertation develops a framework to approach musical hybridity by considering style and genre interactions as an analytical layer of combinations of identities. It engages with the structural, contextual, and perceptual aspects of music by mixing perspectives from music studies with postcolonial studies, situated cognition, and genre studies. Hybridity is...
What follows is a strictly post-genomic dissertation. Over the past five years, I have strived to leave the nucleus behind, and even the endoplasmic reticulum and golgi apparatus. The human genome was sequenced over 15 years before the submission of this document, and the world changed somewhat less than anticipated—besides...
Literary critics typically oppose chronological and anachronistic historiographical schemes. In paired readings of early modern and contemporary poets, my dissertation, “The Shock of the Old: Periodization, Poetics, and Diachronic Exchange between the Renaissance and the Avant-Garde” investigates a series of poetic texts that defy this opposition. The poetic objects I...
Wind pollination has evolved from animal pollination at least 65 times in flowering plants, but the reverse transition is rare. Wind pollination is usually accompanied by the loss of traits that attract pollinators, and re-evolving them may be difficult. This dissertation examines this rare transition using Artocarpus (ca. 70 spp.,...
Mechanisms for sensing fluid flow are well studied in arthropods and in some aquatic mammals, but we know very little about how terrestrial mammals detect and localize airflow (Chapter 1). In this thesis, I will describe a series of studies in rodents that investigate the behavioral, mechanical, and neural basis...
The limits of miniaturization of electronic device components and the steady need for faster computation power have motivated the discovery and cultivation of low-dimensional materials. Among these, two-dimensional (2D) materials have exhibited a wide range of superlative optoelectronic, thermal and mechanical properties. The interest in 2D materials took-off with the...
Metabolic engineering of microorganisms to produce useful compounds from renewable substrates is a promising means for sustainable, on-demand production of chemicals. However, efforts to design and engineer microbial cell factories are constrained by costly and slow “build” times in which each genetic variation requires re-engineering a new strain for each...
Totipotent cells have the highest developmental potential and can only be created by nuclear transfer into oocytes. Identities of maternal factors that can induce this reprogramming remain a mystery. In this report, we demonstrate induction of totipotency on mouse embryonic stem cells by introducing six factors, Hist1h2aa, H3f3b, H1foo, p-Npm2,...
X-ray Fluorescence Microscopy (XFM) is a useful technique for study of biological samples. XFM was used to map and quantify endogenous biological elements as well as exogenous materials in biological samples, such as the distribution of titanium dioxide (TiO2) nanoparticles. TiO2 nanoparticles are produced for many different purposes, including development...
Understanding electrical circuits can be difficult for novices of all ages (Grotzer & Sudbury, 2000; Osborne, 1983; Shipstone, 1984; Tarciso Borges, 1999). Research shows that novices tend to have inadequate understandings of what happens at the level of atoms and electrons, leading to difficulty predicting the outcomes of electrical circuits...
Greater interest in self-directed professions, like entrepreneurship, have led to a growth in informal workplace communities and social technologies that support new ways of working. However, we have little understanding of how these socio-technical environments support opportunities for professional skill development. The goal of this dissertation is to understand how...
One seismologist’s noise is another seismologist’s signal. What was once disregarded is now routinely processed as dense arrays of broadband seismometers continuously record small amplitude Earth motions, presenting an immense wealth of data. This dissertation presents three projects where ambient seismic noise, generated by ocean wave interactions with the solid...
The studies presented in this dissertation combine radiogenic and stable strontium isotope ratios (87Sr/86Sr and 88/86Sr, respectively), radiogenic and stable carbon isotope ratios (Δ14C and 13C, respectively), and bulk ion geochemistry to trace the sources and cycling of C in three glaciated environments (New Zealand, Iceland, and Greenland). A primary...
The anode and cathode are main components in a battery system. In this dissertation, Group IV inter-metallics and LiMn2O4 are studied as anode and cathode materials for Li-ion batteries respectively. Preliminary investigation of a multi-valent cathode material for next generation batteries is also introduced.
Group IV inter-metallics electrochemically alloy with...
The unprecedented crimes of World War Two, especially those committed by the Nazi state, unleashed an equally unprecedented effort to hold perpetrators accountable and secure justice for millions of victims. This effort encompassed hundreds of trials of thousands of individuals in the immediate postwar period and continues to the present...
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The analysis of citations to scientific publications has become a tool in the evaluation of a researcher’s work, especially due to an ever-increasing production volume. Despite its acknowledged shortcomings and the ongoing debate on their meaning, citations are still primarily viewed as endorsements and as indicators of the...
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Socially relevant situations that involve strategic interactions are widespread among animals and humans alike. To study these situations, theoretical and experimental research has adopted a game theoretical perspective, generating valuable insights about human behavior. However, most of the results reported so far have been obtained from a population...
This working paper focuses on the themes, authors, and changing modes of production of 152 booklets published (or purchased) in Nigeria relating to marriage. The author obtained them from bookshops mainly in Ibadan and Lagos, from church bookstores in Ado-Ekiti and Kabba, but also from motor parks in Lokoja, Kaduna,...
This paper examines conflictual relationships among British members of the Gold Coast administration. It adds to the literature that problematizes earlier notions of colonialism by highlighting tensions and contradictions inherent in colonial governance structures. This paper argues that at its inception, the Gold Coast colonial administration had deep cracks as...
Spinal cord injury occurs with a worldwide incidence of 13-33 cases per million per year, and more than 2.5 million patients worldwide suffer from spinal cord injury (SCI)-related disability (1, 2). Different methods have been attempted to promote axonal regeneration, including neurotrophin injection, hydrogel injection, olfactory ensheathing cells implantation and...
The aim of this dissertation is to make sense of nearly a century and a half's worth of observations concerning skin based electroadhesion phenomena. While this is a noble goal in and of itself, further motivation of this work is drawn from fact that the electroadhesive effect is increasingly being...