Portrait of the Galaxy is a snapshot from a 3d rendering of a galaxy that displays the complex structure of the gas component of the simulation. This gas component is difficult to observe in real telescopes but with visualizations and simulations like these we can begin to understand how to...
This is a movie of three galaxy formation simulations I ran as part of my research.
The color of each pixel represents the temperature of the gas (blue for cold and green for hot) and the brightness of each pixel represents the density (dim for low density bright for high...
Three-dimensional imaging techniques have been widely used in both industry and academia. Time-of-flight (ToF) sensors offer a promising method of 3D imaging due to compact size and low complexity. However, state-of-the-art ToF sensors only have depth resolutions of centimeters due to limitations in the modulation frequencies that can be used....
This is a visualization of an event reconstructed in CMS HGCal. This event is consist of 10 pions with a transverse momentum of 35 GeV. The reconstruction algorithm groups all valid energy deposits (hits) into clusters, each incoming particle having one or a few corresponding clusters, so that the energy...
This dissertation examines the nature and development of Protestant ideology in Tudor England. Historians have traditionally seen Tudor Protestants as classic "magisterial" reformers. Unlike "radical reformers," who formed separated sects and rejected the union of church and state, English Protestants are seen as deeply committed to royal authority and the...
Measurements of the ratios of charged kaon decay rates for Ke3/K2pi, Kmu3/K2pi and Kmu3/Ke3 are presented. These measurements are based on charged kaon decays collected in a dedicated run in 2003 by the NA48/2 experiment at CERN. The results obtained are Ke3/K2pi = 0.2470 +- 0.0009 (stat) +- 0.0004 (syst)...
This dissertation investigates whether residents of Windhoek's squatter settlements are changing urban space through their efforts to secure housing and to conduct remunerative work from their dwellings. Studies about the informal economy have moved from analysis of it as a distinct sector to the social and political processes that create...
Self-assembly is the process by which objects autonomously assemble into complexes. It is believed that self-assembly technology will ultimately permit the precise fabrication of complex nanostructures. Of particular interest are self-assembly systems that are highly programmable. That is, we can view a self-assembly system as analogous to a program, the...
RNA interference (RNAi) is a newly discovered gene control pathway that silences gene expression in response to double-stranded RNA. This sequence-specific downregulation occurs at the level of mRNA stability, and is directed by the double-stranded RNA trigger itself. RNAi can be separated into two distinct steps; during the initiation phase,...
This thesis comprises three essays addressing theory and evidence on the household response to tax-favored saving incentive schemes, with a particular emphasis on household risk taking. The US tax code and related regulatory institutions offer a variety of incentives to encourage US households to save and participate in risky investment...
Epstein-Barr virus (EBV) is a human gamma-herpesvirus that primarily infects B cells and epithelial cells. While the glycoproteins required for entry into these two cell types differ, the gH/gL glycoprotein complex is essential for entry into both epithelial and B cells. Analysis of gH protein sequences from three gamma-herpesviruses: EBV,...
This dissertation is composed of readings of four novellas: two by the Swiss writer Gottfried Keller and two by the English novelist George Eliot. It focuses on the motif and concept of treasure (Schatz). Beginning with the figurative and rhetorical employment of "treasure" in the stories, each reading proceeds to...
This dissertation expands on the existing disclosure theory by considering the monitoring role of a firm's disclosure as well as recognizing how a firm's disclosure is influenced by the firm's monitoring mechanisms. The first chapter of the dissertation examines the effect of corporate governance on a firm's earnings reporting process....
The representation and communication of spatial information is important to the functioning of children and adults in the physical world. Yet little research has included both areas in the same studies. This research program was designed to investigate both the communication and representation of spatial information within a developmental context....
The stratigraphic record of the Phanerozoic provides key evidence of temporal changes in the global carbon cycle over the past 560 myr of Earth history. Measurements of carbon concentrations in ancient marine sediment, in conjunction with a chronological framework, provide a means to reconstruct burial flux history and, thus, evaluate...
This dissertation examines the impact of product returns on effective supply chain management. Within this area of research, known as Closed-Loop Supply Chain Management, we consider both strategic and tactical level reverse logistics and inventory management problems from the perspective of a firm which must efficiently process returned items. More...
The [(salen)CrCl + LB] catalyst system was found to be a highly active catalyst system for the [aziridine + CO<sub>2</sub>] coupling reaction, and exhibited a marked preference for the formation of 5-substituted oxazolidinone product, especially in the absence of cocatalyst. The activity of this catalyst system is optimized by modifying...
The ubiquitin-proteasome system degrades regulatory proteins and thereby controls a broad range of cellular processes such as the cell cycle, DNA-repair, gene transcription and signal transduction. The proteasome typically degrades its substrates completely into small peptides. However, biological exceptions do occur. For example, the activity of a handful of transcriptional...
The work described here includes both fundamental and application based studies centered around the use of plasmonic sensors. Fundamental studies focus on probing the optical properties of nanosphere lithography (NSL) fabricated Ag nanoparticles, while surface-enhanced Raman spectroscopy (SERS) sensors are applied to identify and characterize artists' red dye and red...
UV Raman spectroscopy is a powerful tool to investigate hydrocarbons-zeolite systems, including the coke formation mechanism during MTH reactions, the sorbet-framework interactions and the quantitative analysis of catalytic reactions.
First, methanol, dimethyl ether and ethylene reactions were carried out on H-MFI with different Si/Al atomic ratios to study the coke...
Assets are ubiquitous, required for consumer behaviors and meaningful in American society. Though assets have a central role in society, they have been considered primarily for what they can buy. This continual focus on assets as an instrument for exchange masks the fact that assets also may serve as a...
A spokesman for the American Revolution, John Adams, famously claimed that a third of colonists supported independence, a third supported Britain, and a third remained neutral. Since then historians have struggled to understand the mixed loyalties of the Revolutionary generation.
"The Popular Politics of Loyalism During the American Revolution, 1774-1790,"...
It has commonly been observed that a person's performance on a self-regulation activity is often impaired when he or she has already performed a prior task that requires substantial self-regulation, a phenomenon termed as the regulatory depletion effect. The prevailing explanation for this effect, as reported in the literature, is...
This dissertation describes the development and use of novel chemical affinity templates to direct the assembly and preserve the activity of biological molecules in surface- and solution-based biomolecular assays. The majority of work described herein focuses on advancing biological nanoarray technology to enable the study of fundamentally important biological processes...
A comprehensive understanding of human memory requires both cognitive and neural descriptions of memory processes along with a conception of how memory processing drives behavioral responses and subjective experiences. Noninvasive neuroimaging techniques have greatly extended our understanding of the functional characteristics of human memory, and how neural events give rise...
Since the beginning of the 21st century, the idea of building a Latin American musical discourse has returned to the artistic discussion, taking into account the peculiarities of cultural syncretism that manifest in the different countries of the region. From the most diverse aesthetics and through different musical media, a...
Skeletal sexual dimorphism presents itself in humans primarily through the anatomical shape of the cranium and pelvis. However, some physical anthropologists maintain that climate could have an effect on human sexual dimorphism. Despite ongoing research pertaining to climatic effects on soft tissue or size dimorphism, little to no research has...
Physiological linkage (i.e., the covariation of moment-to-moment physiology between individuals) is thought to play an important role in relationship functioning. The present study examined physiological linkage across interbeat interval (IBI) and skin conductance levels (SCL) in a sample of married spouses (N=106) during both a pleasant and a conflict conversation...
Expanding on research done on the mental health and happiness benefits associated with romantic relationships, this study investigates whether identity denial, the experience of being socially denied one’s chosen identity by having others refuse to acknowledge that identity, presents a challenge for bisexual people within committed romantic relationships. For straight,...
Posttraumatic stress disorder (PTSD) is an anxiety disorder characterized by flashbacks of the traumatic event and high comorbidity with major depressive disorder (MDD). Prior stress is known to increase the likelihood of developing PTSD after experiencing a traumatic event. Currently, PTSD is diagnosed clinically, its biological etiology is not known...
Anxiety disorders are the most common group of mental illnesses in the United States and affect over 15% of the population. Prior work utilizing electroencephalogram (EEG) to investigate event-related potentials (ERPs) from the scalp has shown success in isolating certain neural correlates related to increased risk for developing anxiety disorders....
Given any polyhedron in R3, we can cut it open along its edges, flatten it out, and obtain a polygon in the plane R2. In this project, we explored the opposite process, an open question that was first posed about 70 years ago: given a polygon in R2, what is...
The bacterial CRISPR/Cas9 system shows promise as a genome-editing tool to treat human disease. It is integral to understand the binding and unbinding kinetics of Cas9 to its target DNA to study specificity of the Cas9 protein. Standard practices involve the use of negatively charged polymer Heparin to reduce unspecific...
Due to their ability to be engineered for specific cellular targeting, nanoparticles (NPs) have emerged as promising drug delivery vessels for immunotherapeutic and vaccination treatments. However, a major unsolved obstacle for cell-specific nanoparticle delivery is non-specific circulatory clearance by the mononuclear-phagocytic system(MPS). Comprised of various phagocytic cells, the MPS removes...
This study aims to advance our basic understanding of how we perceive objects in our environment. It’s unclear whether we understand object structure based on only how we perceive or on how it truly exists in the world. Examining eye-movements provides insight into how our visual system represents and understands...
In indoor environments, bacteria face selective pressure to carry antibiotic resistant genes (ARGs) from antimicrobial substances used in furniture, building materials, and personal care products. Humans rely on antibiotics to clear bacterial infections, so understanding the way in which these genes are transferred, i.e., on mobile genetic elements, is critical....
With a large sphere of activity and ability to transfer data through wireless communication system, drones have proven to be more and more useful in both research and manufacturing. Whether by allowing researchers to collect measurements or filmmakers to attain aerial shots, the use of drone has allowed collection of...
Previous research has shown that bodily gesture aids in learning words and is useful for musical expression. However, no studies to date have examined the use of gesture in learning words and music together. The original impetus for the present study was observing students with cognitive disabilities learn musical songs,...
Patients with psychosis experience deficits in multisensory integration (MSI), or the communication between different sensory modalities, such as sound and sight. One way to assess multisensory integrations is by utilizing voice-pitch tasks in which participants hear the pitch of their own voice artificially altered by a computer. When healthy individuals...
Standard narratives on the relationship between art and urban development detail art networks as complicit agents in processes of upscaling and gentrification connected to the political and economic elite. My thesis challenges the conventional narrative by investigating the relationship between grassroots art spaces, tied to local, community- based interests, and...
Negative emotional behaviors, such as criticism, defensiveness, contempt, and stonewalling, that spouses may show during conflict are key predictors of marital dissatisfaction. Existing research has focused on middle-class couples, but little is known about how these negative emotional behaviors predict marital satisfaction among couples from socioeconomically diverse backgrounds. The present...
The goal of this research paper is to analyze concepts of armed conflict and peacebuilding from a gender perspective using a feminist epistemology approach.
I examine the impact of armed conflict on women, and the implications of women’s roles in armed conflict and in peacebuilding processes post-conflict. In doing so,...
In the Marvel Comics series Moon Knight, a mercenary believes an ancient Egyptian deity has brought him back from the dead so he can become the eponymous superhero. However, the mercenary’s symptoms of schizophrenia suggest he is instead simply suffering from a psychological break. From 1975-1999, Moon Knight stories used...
Over the last decades, there have been many changes in the business world that are associated with 52 percent of Fortune 500 companies either going bankrupt, being acquired by other companies, or ceasing to exist. One critical change is the transformation of the economy into a knowledge-based economy, where information...
It has been hypothesized that mindfulness-based programs with a primary focus on teaching self-compassion or empathy will have greater effects on self-compassion and empathy than will mindfulness-based exposure programs, which focus primarily on enhancing present moment awareness and reducing distress. However, because research on mindfulness-based exposure programs has centered on...
When navigating through space, the brain must integrate sensory information with past experiences to choose behaviors that are most likely to produce a positive outcome. Striatal medium spiny neurons (MSNs) expressing dopamine receptor 1 (D1) and dopamine receptor 2 (D2) receive sensory and motor information from cortical and midbrain regions...
There are few concerns greater than those of a parent with an adult with an intellectual or developmental disability (I/DD). How is she or he going to be taken care of as she or he ages? The government provides services and support in the pursuit of care and services, but...
In the Western classical art music tradition, a high level of music performance is achieved at the intersection of a musician's emotional, cognitive, and physical processes. Expert classical musicians have both an aural imagining of the sound they intend to produce and the physical associations of what it feels like...
The porphyrazines (pzs), a class of porphyrin derivatives, have shown potential as therapeutic and imaging agents due to a combination of their near-IR absorbance/fluorescence and their enhanced chemical flexibility. Cell viability/proliferation assays and fluorescence microscopy were carried out in both tumor and normal cells to characterize the biological activity of...
The variable effects of self-awareness may be a result of multiple states of awareness being condensed under the umbrella term, "self-awareness". We posit that the cognitive and behavioral effects of self-awareness are largely dependent on another variable, level of abstraction, which modulates self-awareness on a continuum between conceptual and perceptual...
Spontaneous regeneration in the adult mammalian central nervous system is rare, minimal, and generally does not lead to substantial functional recovery. Tissue engineering strategies to promote nerve regeneration aim to provide an environment that is physically and chemically engineered to enhance tissue formation. Strategic design of this environment is crucial...
The study of granular matter is both scientifically intriguing and industrially important, yet it presents several unique characteristics and challenges. The discrete nature of granular materials often precludes the use of the continuum descriptions that are so commonly used for fluids, so alternative methods must be developed. Particles interact via...
The detection of bio-molecules (e.g. nucleic acids and proteins) is the bedrock upon which research in the life sciences and diagnostic medicine rests. For nucleic acids, the polymerase chain reaction (PCR) is the ultimate in terms of target detection sensitivity (10s - 100s of copies/sample). For proteins, the enzyme-linked immunosorbent...
Frictionless Information Systems (FIS) are a class of software systems that automatically bring users information and services related to what they are doing. These systems bridge the gap between the information a user wants and the repositories that contain the information - making the user more effective and informed. By...
Downsizings are now so pervasive that millions of Americans are laid off each year with the stated purpose of improving their organizations' financial outcomes. However, one of the unforeseen negative consequences of downsizings is high attrition by employees who "survive" the layoffs. This dissertation seeks to extend our understanding of...
The emergence of antimicrobial resistance and the growing concern to produce new drugs have influenced an increase in the amount of research directed towards the engineering of novel polyketides. The polyketide carbon backbone is synthesized by a set of enzymes known as polyketide synthases (PKSs). These catalyze the formation of...
Hypoxia is a reduction in the normal level of oxygen tension and occurs during acute and chronic vascular disease, pulmonary disease, and cancer. The key transcription factor that regulates the cellular responses to hypoxia is hypoxia-inducible-factor-1 (HIF-1). Understanding how HIF-1 is regulated is fundamental for understanding the biology of tumor...
This dissertation addresses the process-pathways running between immigrant adolescents' life experiences and their engagement in school by providing an ecocultural perspective on self-regulation. While the role of social context, such as stress and resources, has been identified as critical in its influence on different dimensions of adolescent development, research on...
This dissertation studies two long-standing asset pricing anomalies: "Value and Growth Effects" and "Momentum Effects" via the channel of market imperfections. These market imperfections stem from basic information asymmetry problem, and take forms of contracting problems and less than perfectly competitive information intermediaries.
The first essay (joint with Zhi Da)...
This thesis concerns the development of robust algorithms for large-scale nonlinear programming. Despite recent advancements in high-performance computing power, classes of problems exist that continue to challenge the practical limits of contemporary optimization methods. The focus of this dissertation is the design and analysis of algorithms intended to achieve economy...
The ready-mix concrete industry is a fascinating laboratory for the study of industry dynamics. Concrete plants produce a single homogeneous product with technology and equipment that has changed little over the last 50 years. Building a plant entails substantial sunk costs since the machinery used to produce ready-mix cannot easily...
Nature often uses reaction-diffusion(RD) as a means of making structures and materials of unique properties or morphologies on scales from macro- (e.g., stripes in zebras, tigers, and seashells, and formations in trees, agates, and rocks) to microscopic (e.g., cellular growth, chemotaxis and biological waves). However, reaction-diffusion phenomena have not yet...
Bosnian women war refugees are not only trauma survivors, but are actively engaged in economic and social practices that shape their American sites of relocation. These economic activities--wage labor, and unremunerated volunteer and kin labor--are embedded in a moral framework of mutual obligation rooted in the concept veze / connections,...
The extracellular matrix (ECM) is an environment rich in structural and signaling molecules, including growth factors and cytokines. Together, these signals are capable of changing cellular morphology and gene expression in response to extracellular environmental cues. Structural proteins in the ECM such as laminin transduce their signals through integrin receptors...
Motivated by applications to microfluidic separation systems like Capillary Electrophoresis (CE) and Capillary Electrochromatography (CEC), the research described in this dissertation analyzes through numerical and asymptotic methods the effect of variation in the wall zeta potential (or surface charge) on the electroosmotic flow field in a microchannel and the effect...
The classic error bounds for quasi-Monte Carlo approximation follow the Koksma-Hlawka inequality based on the assumption that the integrand has finite variation. Unfortunately, not all functions have this property. In particular, integrands for common applications in finance, such as option pricing, do not typically have bounded variation. In contrast to...
Part 1. The complex folded structures associated with RNA allow for specific protein-RNA interactions and also create binding sites for small molecules. Developing organic molecules that can bind RNA with high affinity and specificity is a challenge that must be overcome for RNA to be considered a viable drug target....
It's quite common for the novice musician to forget their place in the song, miss the change to a new section, or be unable to play in the key or at the tempo chosen by the leader. Every type of improvisational playing requires the player to follow a set of...
This thesis consists of the synthesis and photophysical characterization of chlorophyll- and porphyrin- based multichromophore arrays designed for the purpose of studying energy and charge transfer therein. The first series of arrays consists of donor-acceptor dyads in which various arylene diimide electron acceptors are attached through a phenyl group to...
We prove the L<SUP>2</SUP>-convergence of polynomial ergodic averages of multiple commuting transformations for totally ergodic systems. We show that for each set of polynomials, each average is controlled by a particular characteristic factor introduced by Host and Kra, which is an inverse limit of nilsystems. We then investigate for which...
Initial studies described the ability of CD4+CD25+ T regulatory (Treg) cells in suppressing autoimmune diseases in animal models. An emerging interest has focused on the potential role of Treg cells in cancer development and progression as they have been shown to suppress anti-tumor immunity. In the present study, CD4+CD25- T...
The general goal of this dissertation research was to examine linguistic and cognitive mechanisms in foreign vocabulary learning within theoretical frameworks of working memory and connectionist word processing models.
In Study 1, the effect of bimodal (auditory-and-visual) vs. unimodal (auditory-only) presentation on foreign word learning was examined at different levels...
Supramolecular chemistry has proven to be an effective strategy for bottom-up fabrication of monodisperse, functional nanostructures. However, most applications require these nanostructures to be spatially or orientationally ordered. This thesis investigates patterning and spatial confinement as tools for controlling order in self-assembling systems.
We first look to improve the ordering...
The aim of the present investigation was to examine the nature of individuals' parasocial relationships (one-sided attachments to media figures, Horton & Wohl, 1956). Five studies were designed to assess the prevalence and strength of individuals' attachments to their favorite television characters, manipulate exposure to the character or control targets,...
This dissertation is a comprehensive study on mutual fund flows and the portfolio liquidity of mutual funds. The dissertation is organized into three chapters. In the first chapter, I consider the problem of aligning the incentives between the mutual fund investor and the mutual fund manager. I show that the...
Theoretical studies on electronic structure governing charge transport properties are investigated to understand and improve the prediction of electron charge carrier organic semiconductors used in field-effect transistors. Perfluorinated oligothiophene semiconductors have shown experimental n-type behavior, but placement of fluorinated aryl groups changes charge polarities. Models were developed to investigate how...
Homotopy Gerstenhaber structure is shown to exist on the deformation complex of a morphism of associative algebras. The main step of the construction is extension of a B-infinity algebra by an associative algebra. Actions of B-infinity algebras on associative and B-infinity algebras are analyzed, extensions of B-infinity algebras by associative...
This dissertation examines the transformation of the city-state of Florence from a republic to a principality during the first half of the sixteenth century. It explores how this fundamental change in political organization altered the culture and society of the Florentine office-holding class. The dissertation describes the course of socio-cultural...
This dissertation deploys an interdisciplinary methodology, extending what is conventionally understood as discourse to include performance. It brings together the fields of performance studies, discourse analysis and theatre studies to document, contextualize, and analyze the events after the Los Angeles rebellion of 1992. It examines gang youth who turned to...
The current research tested the principles of role congruity theory of prejudice, which states that prejudice arises from an incongruity between a group stereotype and social role characteristics (i.e., the attributes and behaviors prescribed by the social role), such that prejudice occurs when members of a group enter or attempt...
Studies on consolidated democracies have long concluded that there is a positive relationship between socioeconomic status and turnout. The strength of the empirical findings that linked electoral participation to socioeconomic variables elevated this correlation to a law-like principle and made it possible to assume that this electoral behavior would prevail...
This dissertation is a study of the figure of the intruder in postcolonial francophone literature, film and graphic novels published and released in the second half of the 20th and early 21st century which develop a discourse on the Maghreb or the Maghrebian dispora in France. Postcolonial critics have long...
This study examines the intersection between art and politics in the salons of Les XX, a group of some twenty, mostly Belgian, artists organizing international exhibitions of art in Brussels, Belgium between 1884 and 1893. The fact that Les XX derived a significant base of support from some of the...
Anthony Braxton’s Trillium J, part of an ambitious planned “complex” of 36 one-act operas, premiered in 2014. Very little writing—anecdotal, journalistic, nor scholarly—exists on these works, so this research provides a critical introduction, contextualizing the operas within Braxton’s oeuvre and discussing the works’ fundamental musical materials and organization.
Examples from...
Presentation slides from Open Repositories, 2018. Jekyll is an open source publishing system that relies on plain text files to produce websites. Because it was created as a simple blogging platform, Jekyll can be extended to support the journal publishing needs of any library with a scholarly communication or digital...
Several phosphonate-functionalized molecular
squares have been successfully synthesized,
and the fabrication of multilayer films
on both conductive and semiconducting
platforms has been demonstrated. These
films were grown using the well-documented
zirconium phosphonate multilayer method.
The layer-by-layer growth rate is uniform.
Experiments suggest, however, that the
molecular squares adopt a semi-collapsed...
The development and applications of
organic/DNA molecules for the use of DNA
detection systems are reported here. In particular,
two different hybrids are synthesized:
DNA/polymer hybrids and small-molecule
DNA hybrids. DNA/polymer hybrids are especially
useful considering that their functionality
may be varied according to the polymer
selected. The hybrids are...
Recent research suggests that ultraviolet
illumination is essential for the creation of
monolayers of Undecylenic Acid Methyl
Ester (UDAME), as it is believed that the
UV illumination initiates the radical-chain
polymerization. Samples created without
UV illumination, however, also show signs
of a monolayer. In this study, samples were
analyzed using...
This research project explores two different
processes that can be used to pattern
organic molecules on silicon. In the first
process, hydrogen-terminated silicon surfaces
were anodized in nanometer scale with
a contact-mode atomic force microscope
(AFM). Anodization was done by applying a
positive bias voltage to the surface with
respect...
Feedback-controlled lithography (FCL)
enables atomically precise patterning of
individual molecules on the technologically
significant Si(100)-2 x 1:H surface. However,
because it is performed in an ultrahigh vacuum
(UHV) environment, FCL has thus far
been restricted to surface chemistries that
can be delivered in the gas phase. The present
research attempts...
Transmission and reflection diffraction
gratings were fabricated by micropatterning
polymers on transparent substrates and
drop-coating polymers onto etched silicon
wafers. Exposure of these gratings to three
nerve toxin mimics at very low concentrations
resulted in mimic sorption by the polymers,
changing the polymer’s refractive
index. As a result, the grating’s...
The effects of 13 nm Au colloid and 10 nm Ag
colloid on the growth of the yeast species
Saccharomyces cerevisiae were compared
to control samples cultured in a growth
media of yeast extract, bacto peptone, and
dextrose (YPD) to determine the toxicity of
nanoparticles. Growth curves were generated
for...
In modern medicine, physicians destroy
otherwise healthy tissues in patients’ bodies
because of the lack of site-target specificity
and sensitivity in detecting and attacking
cancerous cells. Many cancer patients are
left with the difficult task of weighing the
benefits against the harm of undergoing
current cancer treatments. Members of the...
Chemists and physicists have been interested
in the optical properties of metal nanoparticles
since the time of Michael Faraday.1
New approximation techniques for different
sizes and geometries have created renewed
interest in and investigation of these particles.
Many different arrays of particle extinctions
of various shapes and sizes have been...