FOXA1 is a FKHD family protein that plays pioneering roles in lineage-specific enhancer activation and gene transcription. Through genome-wide location analyses, here we show that FOXA1 expression and occupancy are, in turn, required for the maintenance of these epigenetic signatures, namely DNA hypomethylation and histone 3 lysine 4 methylation. Mechanistically,...
Analytic jurisprudence is the field organized around the “What is law?” question. When most scholars approach the “What is law?” question, they suppose that the goal of such inquiry is to discover, or to accurately represent, the true nature of law. Consequently, these scholars reject the notion that the goal...
This dissertation explores the renewed historical significance of the (geo)political demand to redraft national constitutions in the Americas. Building on previous work, my dissertation constructs a transnational lens to underline the intersectionality of the social struggles that catalyzed the Venezuelan Constituent Assembly process begun in 1999 and the Ecuadorian experience...
How can gatekeeping theory in the circulation of cultural objects, including knowledge production, inform the way cultural sociology investigates the role of the producer and the cultural object as “gated” entities? Using the case of producers working under the rubric of “Contemporary African art” to investigate opportunities and restrictions to...
Dopaminergic neurons in the substantia nigra pars compacta are richly innervated by GABAergic neurons. The postsynaptic effects of GABA on SNc DA neurons are mediated by a mixture of GABAA and GABAB receptors. Although activation of GABAA receptors inhibits spike generation, the consequences of GABAB receptor activation are less well...
This dissertation presents a Nuclear Magnetic Resonance (NMR) study of a novel anisotropic superconductor, HgBa$_{2}$CuO$_{4+\delta}$ (Hg1201) and unconventional strain dependence of the mean free path of silica aerogel. Hg1201 is one of the most structurally simple cuprates known. Therefore, it is an ideal compound in investigation of various phases in...
Increasing energy demand due to rapid growth in population and industrialization along with environmental crisis has led to the search for cheap, environmentally friendly, and nontoxic methods for generation of energy. However, most alternative energy sources such as photovoltaic, biofuels, hydraulic power, wind power, and geothermal energy, are characterized by...
Age-related cognitive deficits are observed in both humans and animals. Yet, the molecular mechanisms underlying these deficits are not yet fully elucidated. In aged animals, a decrease in intrinsic excitability of pyramidal neurons from the CA1 sub-region of hippocampus is believed to contribute to age-related cognitive impairments, but the molecular...
The impacts of many important technologies are limited by the availability of better-performing materials. One factor limiting the ability of engineers to develop better materials is the speed at which they can search through possible formulations and processing schemes. Recently, machine learning algorithms have emerged as a possible route to...
Loss of inhibitory control from descending serotonergic (5-HT) fibers deregulates the excitability of spinal motoneurons and interneurons following spinal cord injury (SCI). Exaggerated synaptic activity triggers long-lasting excitatory postsynaptic potentials (long EPSPs) in hyperexcitable motoneurons to ultimately drive muscle spasms at the chronic stage of SCI. Deep dorsal horn (DDH)...