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-
- Description:
- Episodic memory provides a means by which we are able to reflect on the past, make decisions about the future, and form a learned identity. Even subtle changes to our memory can have a detrimental impact on our daily lives. Memory declines as we age, and clinically salient impairment is...
- Keyword:
- aging, hippocampus, transcranial magnetic stimulation, precision, recollection, and human memory
- Subject:
- Cognitive psychology, Aging, and Neurosciences
- Creator:
- Nilakantan, Aneesha S
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_674620 and http://dissertations.umi.com/northwestern:14737
-
- Description:
- Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are non-selective cation channels expressed in the brain and heart where they exert control over many diverse physiological properties. In the hippocampus, HCN channels are enriched in a dendritic gradient within CA1 pyramidal cells where they reduce dendritic integration and dampen neuronal excitability. HCN channels...
- Keyword:
- Temporal Lobe Epilepsy, HCN channels, Phosphorylation, and TRIP8b
- Subject:
- Neurosciences
- Creator:
- Foote, Kendall Marie
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_682272 and http://dissertations.umi.com/northwestern:14781
-
- Description:
- Decision making is an essential and indispensable element in everyday life. It is posited that parallel, distinct systems subserving deliberative, goal-directed control and automatic, habitual control underlie decision making. Computational accounts suggest that model-based and model-free learning strategies give rise to these two systems respectively. The model-based system is a...
- Keyword:
- Reward, fMRI, and Decision making
- Subject:
- Neurosciences
- Creator:
- Zhong, Wanting
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14552 and etdadmin_upload_647965
-
- Description:
- For years, neuroscientists have strived to understand memory consolidation, where salient memories are sorted and organized into distributed cortical networks for long-term storage. A large body of sleep research suggests that slow-wave sleep is an optimal opportunity for memory consolidation, and that consolidation is driven, at least in part, by...
- Keyword:
- olfactory reactivation, functional MRI, slow-wave sleep, ventromedial prefrontal cortex, memory replay, and memory consolidation
- Subject:
- Neurosciences
- Creator:
- Shanahan, Laura Kathleen
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14493 and etdadmin_upload_634332
-
- Description:
- This thesis focuses on the development of a cochlear implant (CI) that uses photons to stimulate surviving auditory neurons in severe-to-profoundly deaf individuals. The benefit of optical over electrical stimulation is its spatial selectivity with the potential to create significantly more independent channels to encode acoustic information and likely enhances...
- Subject:
- Audiology, Psychology, and Neurosciences
- Creator:
- Xu, Yingyue
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14587 and etdadmin_upload_660188
-
- Description:
- The brain is known to shrink in normal aging or neurodegenerative disease and yet the neurobiological underpinnings of the cortical atrophy remain elusive. The structural changes that represent cortical atrophy can be measured during life using the reliable and quantitative method known as magnetic resonance imaging (MRI). Primary progressive aphasia...
- Keyword:
- primary progressive aphasia, neurons, cortical atrophy, activated microglia, and Alzheimer's disease
- Subject:
- Pathology, Medical imaging, and Neurosciences
- Creator:
- Ohm, Daniel Timothy
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_640035 and http://dissertations.umi.com/northwestern:14532
-
- Description:
- Slow-wave sleep (SWS) is important for overall health since it affects many physiological pathways from cardio-metabolic health to cognitive function. Sleep and autonomic nervous system (ANS) functioning are closely coupled at anatomical and physiological levels. Sleep-related changes in ANS function are likely the main pathway through which SWS affects many...
- Keyword:
- Memory, Sleep, Acoustic Stimulation, Aging, Autonomic Nervous System, and Mild Cognitive Impairment
- Subject:
- Neurosciences
- Creator:
- Papalambros, Penelope Ann
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_635017 and http://dissertations.umi.com/northwestern:14497
-
- Description:
- Store-operated Ca2+ entry (SOCE) is a principal mechanism for generating cellular Ca2+ signals. Store-operated Ca2+ release-activated Ca2+ (CRAC) channels serve an essential role in generating Ca2+ elevations needed for transcriptional, enzymatic, and secretory effector cascades in many cell types. CRAC channels, comprised of the ER Ca2+ sensor STIM and the...
- Subject:
- Biology and Neurosciences
- Creator:
- Toth, Anna
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14766 and etdadmin_upload_679006
-
- Description:
- Rhythmic oscillations in the brain are widespread. Extracellular recordings of local field potentials (LFPs) using methods ranging from microelectrodes to scalp electroencephalography (EEG) have demonstrated that oscillatory dynamics play a vital role in operations such as network synchronization, sensory tuning and information packaging. Empirical and computational evidence suggest that these...
- Subject:
- Neurosciences
- Creator:
- JIang, Han
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_641773 and http://dissertations.umi.com/northwestern:14545
-
- Description:
- Frontotemporal dementia (FTD) encompasses a group of neurodegenerative disorders characterized by cognitive and behavioral impairments. Heterozygous mutations in progranulin (PGRN) cause familial FTD and result in decreased PGRN expression, while homozygous mutations result in complete loss of PGRN expression and lead to the neurodegenerative lysosomal storage disorder neuronal ceroid lipofuscinosis...
- Keyword:
- Progranulin, Frontotemporal Dementia, Lysosome, and Cathepsin D
- Subject:
- Neurosciences
- Creator:
- Valdez, Clarissa
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2017-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14449 and etdadmin_upload_626172
-
- Description:
- The presence of subjective cognitive decline (SCD) among cognitively normal-for-age older adults is increasingly hypothesized to represent a preclinical stage in the development of Alzheimer’s dementia (Jessen et al., 2014). This project aimed to characterize this construct with regard to its cognitive, motor, emotional, and functional features. The first study...
- Keyword:
- subjective cognitive decline, cognitive aging, and Alzheimer's disease
- Subject:
- Clinical psychology and Neurosciences
- Creator:
- Kielb, Stephanie
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14814 and etdadmin_upload_685763
-
- Description:
- One of the most fascinating observations in the brain is that the neural connections change with experience and this phenomenon is called synaptic plasticity. Patterns of activity or neuromodulators can acutely induce changes in the synaptic strength in the brain. My thesis is focused on understanding the mechanisms of plasticity...
- Keyword:
- LTP, PKA, Synaptic potentiation, and Sex differences
- Subject:
- Neurosciences
- Creator:
- Jain, Anant
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_676778 and http://dissertations.umi.com/northwestern:14753
-
- Description:
- Birds such as the barn owl and zebra finch are known for their remarkable hearing abilities that are critical for survival, communication and vocal learning functions. A key to achieving these hearing abilities is the speed and precision required for the temporal coding of sound; a process heavily dependent on...
- Keyword:
- Development, Tonotopy, Voltage dependent sodium channel, Auditory system, Voltage dependent potassium channel, and Nucleus magnocellularis
- Subject:
- Neurosciences
- Creator:
- Hong, Hui
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14516 and etdadmin_upload_638995
-
- Description:
- We have a remarkable ability to perform complex, coordinated movements without much conscious effort. In addition to the computations required to generate commands for muscles, a key aspect of coordinated motor control is incorporating sensory feedback about the movement. One of the most important feedback routes is through proprioception, the...
- Keyword:
- musculoskeletal model, somatosensory cortex, reaching, motion tracking, monkey, and cat hindlimb
- Subject:
- Biomedical engineering and Neurosciences
- Creator:
- Chowdhury, Raeed Hasan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14692 and etdadmin_upload_666011
-
- Description:
- After stroke, inappropriate muscle activity phasing during the locomotor cycle is a key contributor to locomotor impairment. Muscle phasing has been shown to vary between behaviors post-stroke, but the degree to which individuals can voluntarily modulate activity is unclear. This dissertation consists of a series of three studies that investigate...
- Subject:
- Neurosciences
- Creator:
- Mullens, Christopher Howard
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14729 and etdadmin_upload_672305
-
- Description:
- The apolipoprotein E (APOE) E4 isoform is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). While APOE is predominantly expressed by astrocytes in the central nervous system, neuronal expression of APOE is of increasing interest in age-related cognitive impairment, neurological injury, and neurodegeneration. Here we show that endogenous...
- Keyword:
- APOE, Alzheimer, Stem Cells, and CRISPR
- Subject:
- Molecular biology, Medicine, and Neurosciences
- Creator:
- Wadhwani, Anil R
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14520 and etdadmin_upload_639542
-
- Description:
- We perform many movements every day without much deliberation. However, moving can be seen as a form of decision-making since one of many possible movements must be selected and executed. The decision-making processes that underlie movements are influenced by various factors, including sensory perception, energetics, time, perceived rates of failure...
- Keyword:
- hind brain, reticulospinal, decision, escape, spinal cord, and looming
- Subject:
- Biomedical engineering, Neurosciences, and Biomechanics
- Creator:
- Bhattacharyya, Kiran
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_653282 and http://dissertations.umi.com/northwestern:14560
-
- Description:
- Identifying key molecular mechanisms and targets for therapeutic development in sporadic neurodegenerative diseases has been challenging. Therefore, in-depth investigation of genetic forms of disease can provide valuable insight into pathogenic disease mechanisms. The discovery of genetic forms of Parkinson’s disease (PD) has highlighted the importance of the autophagy/lysosomal and mitochondrial/oxidative...
- Subject:
- Neurosciences
- Creator:
- Nguyen, Maria Bac-Ai
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14484 and etdadmin_upload_630756
-
- Description:
- Recent studies have begun to examine white matter connectivity aberrations in psychiatric populations, such as major depressive disorder. Several studies have found reduced white matter integrity (WMI) in depressed samples, though the location of this reduction is not clear. Incorporating symptom measures of depression severity and rumination may allow for...
- Keyword:
- rumination, women's health, depression, and white matter
- Subject:
- Clinical psychology, Psychology, and Neurosciences
- Creator:
- Satyshur, Maureen
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_676234 and http://dissertations.umi.com/northwestern:14751
-
- Description:
- New neurons are continuously produced in the subgranular zone of the dentate gyrus of the hippocampus throughout life. These newborn dentate granule cells (DGCs) undergo a stereotyped process of morphological and functional maturation during the first few weeks after differentiation that recapitulates some aspects of postnatal neuronal development. The inhibitory...
- Keyword:
- running, Fragile X, adult neurogenesis, GABA, dentate gyrus, and synapse
- Subject:
- Neurosciences
- Creator:
- Remmers, Christine L
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_634151 and http://dissertations.umi.com/northwestern:14492
-
- Description:
- Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are two devastating neurodegenerative diseases that affect 100,000s of people globally. They have a severe adverse impact on society, yet there are currently no early diagnostic tools or disease-modifying therapies available. Despite their clinical heterogeneity, evidence points to these diseases being on...
- Keyword:
- microRNA, Compositional Data Analysis, TDP-43 Proteinopathy, FUS Proteinopathy, RNA-Seq, and Mitochondria
- Subject:
- Molecular biology, Bioinformatics, and Neurosciences
- Creator:
- McGee, Warren A
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14675 and etdadmin_upload_663037
-
- Description:
- The cerebellum is involved in sensorimotor processing and motor control in the brain. What has been found across many species for many behaviors is cerebellar Purkinje (Pkj) cells and cerebellar nuclear (CbN) cells show activity that is related to and predictive of movements. Less is known about how patterns of...
- Subject:
- Neurosciences
- Creator:
- Brown, Spencer T
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_669457 and http://dissertations.umi.com/northwestern:14720
-
- Description:
- In mature neurons, postsynaptic NMDARs are segregated into two populations, synaptic and extrasynaptic NMDARs, which differ in localization, function, and associated intracellular cascades. These two pools are connected via lateral diffusion, and receptor exchange between them modulates synaptic NMDAR content (NMDAR-plasticity). Here, we identify the phosphorylation of the PDZ-ligand of...
- Keyword:
- NMDAR, NMDAR-plasticity, Extrasynaptic NMDAR, GluN2B, and PP1
- Subject:
- Pharmacology and Neurosciences
- Creator:
- Chiu, Andrew Michael
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_669024 and http://dissertations.umi.com/northwestern:14717
-
Peripheral Neural Representations of Naturalistic Tactile Stimuli in the Vibrissal-Trigeminal System
- Description:
- Many species of rodents rely on the set of exquisitely sensitive facial vibrissae (whiskers) to guide rich behaviors in which other senses are inadequate. Although whiskers are, like all hairs, inert strands of keratin, they provide the animal with a rich landscape of tactile information which is used to guide...
- Keyword:
- Mechanics, Afferent, Vibrissal, Trigeminal, and Whisker
- Subject:
- Neurosciences
- Creator:
- Bush, Nicholas E
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14697 and etdadmin_upload_666783
-
- Description:
- Contactin associated protein like 2 (CNTNAP2) has emerged as a prominent susceptibility gene implicated in multiple complex neurodevelopmental disorders, including autism spectrum disorders (ASD), intellectual disability (ID), and schizophrenia (SCZ). The presence of seizure comorbidity in many of these cases, as well as inhibitory neuron dysfunction in Cntnap2 knockout (KO)...
- Keyword:
- Epilepsy, Dendrites, Autism, CASK, CNTNAP2, and Interneurons
- Subject:
- Physiology, Molecular biology, and Neurosciences
- Creator:
- Gao, Ruoqi
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14243 and etdadmin_upload_595693
-
- Description:
- Motor planning is fundamental to the performance of everyday reaching movements. The influence of planning is not limited to voluntary movements but extends to involuntary movements initiated in response to sensory stimuli, such as postural perturbations applied to the arm. Stroke alters voluntary reaching and the involuntary response to perturbations,...
- Keyword:
- Startle, Stroke, Motor Planning, and Reaching
- Subject:
- Biomedical engineering and Neurosciences
- Creator:
- Heckman, Rosalind Lauren
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_625731 and http://dissertations.umi.com/northwestern:14442
-
- Description:
- Neurodegenerative diseases (NDs) commonly involve the accumulation and aggregation of neurotoxic proteins that impair and ultimately destroy specific neurons. Considerable evidence from human and animal studies indicates that many NDs show disrupted circadian and sleep as symptoms. Yet little is known about the molecular mechanisms by which genes cause NDs...
- Keyword:
- genetic screen, neurodegeneration, Huntington’s disease, and circadian
- Subject:
- Biology and Neurosciences
- Creator:
- Xu, Fangke
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14655 and etdadmin_upload_662687
-
- Description:
- Dystonia is a movement disorder characterized by involuntary and repetitive co-contractions of the agonist and antagonist muscles. Dystonia 6 (DYT6) is an autosomal dominant dystonia caused by loss of function mutations in the zinc finger transcription factor THAP1. I have generated Thap1 knock-out mice with a view to understanding its...
- Subject:
- Neurosciences
- Creator:
- Frederick, Natalie
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14680 and etdadmin_upload_663120
-
- Description:
- Spinal cord injury (SCI) is a devastating injury, which can be caused by motor vehicle accidents, violence, and non-traumatic causes. These injuries can leave patients with lifelong paralysis, as well as incontinence and life threatening autonomic dysreflexia. There is currently no FDA approved treatment for SCI. Spinal injury disrupts the...
- Keyword:
- Nanotechnology, Fibronectin, Spinal Cord Injury, Fibrosis, Mechanical Properties, and Gliosis
- Subject:
- Biology, Biomechanics, and Neurosciences
- Creator:
- Cooper, John Gregory
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14557 and etdadmin_upload_650745
-
- Description:
- Individuals following a stroke suffer from a host of movement impairments that affect the upper extremity. Hand use is often significantly compromised, especially in individuals with more severe impairments, which makes it difficult for individuals to participate in activities of daily living. One of the major goals of rehabilitation is...
- Keyword:
- Upper Extremity, Stroke, Neuroimaging, Hand, Rehabilitation, and EEG
- Subject:
- Neurosciences
- Creator:
- Wilkins, Kevin Bryant
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14743 and etdadmin_upload_675263
-
- Description:
- Rhythmic fluctuations of electrical activity in the brain provide insights into the proposed mechanism by which we encode experiences and then maintain, forget, modify, and retrieve them. Yet there is still much to learn about how neural oscillations relate to memory function. The purpose of this research is to discover...
- Keyword:
- EEG, Memory, Oscillation, Reactivation, Sleep, and Consolidation
- Subject:
- Cognitive psychology, Psychology, and Neurosciences
- Creator:
- Creery, Jessica Danielle
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/12/2020
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_615973 and http://dissertations.umi.com/northwestern:14395
-
- Description:
- To survive, animals, including human beings, have developed an amazing ability to learn the constantly changing environment. Specifically, detecting specific odorants in a noisy, variable background is crucial for finding food and water, mating, and avoiding potential dangers. For this purpose, rodents have developed an olfactory system that is powerful...
- Keyword:
- Synchronization, Olfactory Bulb, Neuron, Structural Plasticity, Learning, and Rhythms
- Subject:
- Applied mathematics and Neurosciences
- Creator:
- Meng, Hongyu
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/28/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14966 and etdadmin_upload_713722
-
- Description:
- Maneuvering your limbs requires both accurate commands for how to move, and accurate feedback of their true movements. Conventional prosthetic arms currently lack this sense of proprioceptive feedback, which can make daily tasks difficult without close visual monitoring. Although studies have successfully provided artificial proprioceptive feedback to improve control, this...
- Keyword:
- motor adaptation, sensory feedback, and myoelectric prosthesis
- Subject:
- Biomedical engineering and Neurosciences
- Creator:
- Earley, Eric Joseph
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/28/2020
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_713001 and http://dissertations.umi.com/northwestern:14963
-
- Description:
- Neurons are sensitive to the mechanical properties of their environment and show better growth, survival and differentiation when they are cultured in soft environments with mechanical properties similar to those of the brain compared to other tissues. Within the central nervous system (CNS), there is also a range of mechanical...
- Keyword:
- Hydrogels, Peptide amphiphiles, Mechanical properties, aza-glycine, Neurons, and Supramolecular
- Subject:
- Chemistry, Biomedical engineering, and Neurosciences
- Creator:
- Godbe, Jacqueline M
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/28/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15006 and etdadmin_upload_719165
-
- Description:
- Episodic memory provides a means by which we reflect on the past, make decisions about the future, and form a learned identity. Episodic memory depends on the hippocampus as well as on the distributed set of regions that form a hippocampal-cortical network (HCN), including medial prefrontal, posterior cingulate, and medial...
- Keyword:
- memory, hippocampus, brain network, and stimulation
- Subject:
- Neurosciences
- Creator:
- Warren, Kristen N
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:14985 and etdadmin_upload_717587
-
- Description:
- In susceptible individuals, episodic memories of overwhelmingly stressful experiences can give rise to debilitating socio-affective symptoms, including social dysfunction. This occurs even when such memories are not easily accessed for retrieval. In this case, it is generally accepted that the restricted retrieval of such memories is due to their having...
- Keyword:
- Chemogenetics, Hippocampus, Stress, Dentate gyrus, Social behavior, and Oxytocin
- Subject:
- Neurosciences
- Creator:
- Meyer, Mariah Alexie Azuz
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_718313 and http://dissertations.umi.com/northwestern:14995
-
- Description:
- The hippocampus has been identified as a critical structure for supporting spatial memory processes in both humans and animals alike. Many of these processes such as the ability to self-localize in a given environment as well as engage in goal-directed navigation are thought to depend on the location-specific firing of...
- Subject:
- Behavioral sciences, Biophysics, and Neurosciences
- Creator:
- Adoff, Michael David
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/29/2020
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_718033 and http://dissertations.umi.com/northwestern:14990
-
Exploring the effects of phonetic overlap and background noise on incremental processing in children
- Description:
- In everyday conversation, individuals actively process speech in order to comprehend and respond in real-time. As a word unfolds, listeners activate possible lexical candidates and actively determine the target word as they receive more information, a process referred to as incremental processing. This process requires knowledge of one’s native spoken...
- Keyword:
- background noise, phonetic overlap, and incremental processing
- Subject:
- Neurosciences
- Creator:
- Sophia Liu
- Owner:
- Scholarly Digital Publishing
- Date Uploaded:
- 06/08/2020
- Date Modified:
- 07/23/2020
- Date Created:
- 2020-06-01
- Resource Type:
- Conference Proceeding
-
- Description:
- Dynamic decision-making is a complex process that relies on our ability to generate, evaluate and implement a variety of strategies. Understanding how people navigate this process is a difficult problem that requires a wide range of methodologies. This study details a combination of behavioral experiments, computational modeling, and neuroimaging that...
- Keyword:
- Memory Systems, Decision Making, Computational Neuroscience, Learning, Cognitive Modeling, and Category Learning
- Subject:
- Cognitive psychology, Psychology, and Neurosciences
- Creator:
- Reuveni, Ben
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15045 and etdadmin_upload_732002
-
- Description:
- Brain network organization, the emergence of cognition, and the accumulation of neurodegenerative pathology are interwoven concepts frequently studied under the umbrella of behavioral neurology, neuropsychiatry, neuropsychology, and neuropathology. One approach to studying the organization of cognitive processes is to study those with selective deficits in such networks. To understand how...
- Keyword:
- primary progressive aphasia, cortical atrophy, neuroimaging, Alzheimer disease, and brain networks
- Subject:
- Pathology, Medical imaging, and Neurosciences
- Creator:
- Martersteck, Adam Christopher
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_743337 and http://dissertations.umi.com/northwestern:15111
-
- Description:
- The basal ganglia are a remarkably complicated and interconnected tangle of subcortical nuclei whose exact function and composition are hotly debated to this day. What is plainly obvious, however, is that loss of dopaminergic modulation in the basal ganglia, as is the case in Parkinson’s disease (PD) following the progressive...
- Keyword:
- in vivo electrophysiology, anesthesia, basal ganglia, optogenetics, and 6-hydroxydopamine
- Subject:
- Neurosciences
- Creator:
- Kovaleski, Ryan Francis
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_720363 and http://dissertations.umi.com/northwestern:15020
-
- Description:
- The mammalian retina contains three classes of photoreceptors: rods, cones and the recently discovered intrinsically photosensitive retinal ganglion cells (ipRGCs). ipRGCs express the photopigment melanopsin and were initially thought to be a homogeneous population of cells that drive subconscious visual behaviors such as circadian photoentrainment and pupil constriction. However, recent...
- Subject:
- Neurosciences
- Creator:
- Sonoda, Takuma
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15030 and etdadmin_upload_724350
-
- Description:
- Interactions between working memory and long term memory systems are still not well understood, as the systems have long been thought to be mostly separate. An interesting intersection of these memory systems is domain-specific expertise, whereby individuals are able to show supra-span memory for information related to the area of...
- Keyword:
- Domain-specific expertise, Long term memory, Working memory, and Expertise
- Subject:
- Psychology and Neurosciences
- Creator:
- Gigler, Kathryn Lee
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_743356 and http://dissertations.umi.com/northwestern:15112
-
- Description:
- Voltage-gated Na channels are expressed in all neurons, and are responsible for the upstroke of the action potential. They are part of a complex of proteins that includes pore-forming α subunits and auxiliary subunits that modify their trafficking, gating, and function. The modulation of Na channels by auxiliary subunits is...
- Keyword:
- sodium channels, FGF14, resurgent current, beta4, and purkinje cells
- Subject:
- Neurosciences
- Creator:
- White, Hayley Virginia
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15070 and etdadmin_upload_740150
-
- Description:
- Background: Glioblastoma (GBM) tumors are the most malignant brain cancers and are characterized as Grade IV astrocytomas by the World Health Organization. GBM tumors can be classified into three molecular subtypes known as proneural, classical, and mesenchymal. In addition, GBM tumors also have a small population of cells known as...
- Keyword:
- LY6K, Methylation, Glioblastoma, ERK1/2, and CAV-1
- Subject:
- Molecular biology, Oncology, and Neurosciences
- Creator:
- Sastry, Namratha G
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 01/21/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_733180 and http://dissertations.umi.com/northwestern:15049
-
- Description:
- Stroke is the leading cause of permanent adult disability. Subcortical unilateral (hemiparetic) stroke affecting the internal capsule or basal ganglia is the most common of all strokes and usually results in hemiparesis of the contralateral arm and leg. About 80% of the individuals with a moderate to severe hemiparetic stroke...
- Keyword:
- Sensorimotor pathways, brainstem, stroke, spinal cord, and magnetic resonance imaging
- Subject:
- Neurosciences
- Creator:
- Karbasforoushan, Haleh
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15187 and etdadmin_upload_754987
-
- Description:
- Leptin, a peptide mainly secreted in proportion to adipose tissue mass, increases energy expenditure with a parallel increase in breathing. The existence of a leptin-mediated neural circuit linking breathing to metabolism has been speculated, yet the precise central mechanisms were unknown. In my thesis, I show that optogenetic activation of...
- Keyword:
- NALCN, obesity, and Nucleus of the Solitary Tract
- Subject:
- Neurosciences
- Creator:
- Do, Jeehaeh
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_763656 and http://dissertations.umi.com/northwestern:15246
-
- Description:
- Mitochondrial complex I is the primary entry point for electrons into the mitochondrial electron transport chain that is composed of 45 individual protein subunits that are encoded in both the nuclear and mitochondrial genomes. Mitochondrial complex I sits at an important nexus in the essential bioenergetic, biosynthetic, and signaling functions...
- Keyword:
- NDI1, NDUFS2, NDUFS4, Mitochondria, Leigh Syndrome, and Metabolism
- Subject:
- Biology, Aging, and Neurosciences
- Creator:
- McElroy, Gregory Scott
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_746970 and http://dissertations.umi.com/northwestern:15152
-
- Description:
- Considerable progress has been made in characterizing the neural circuits that underlie stress, fear, feeding, and pain. However, little is known about how they affect each other. Stress bidirectionally regulates feeding, either increases (e.g., stress-induced binge eating) or decreases (e.g., stress-induced anorexia), depending on the types of stressors, duration of...
- Keyword:
- LTD, feeding, locus coeruleus, endocannabinoid, and fear
- Subject:
- Neurosciences
- Creator:
- Yang, Ben
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15324 and etdadmin_upload_770239
-
- Description:
- The interaction of amyloid-β (Aβ) with endogenous metal ions is thought to play a role in the pathogenesis of Alzheimer’s disease (AD). However, limited tools exist to study and modulate Aβ-metal binding. The Meade lab has developed cobalt(III) Schiff base (Co(III)-sb) complexes as protein inhibitors that competitively displace metals from...
- Keyword:
- amyloid-beta, aggregation, cobalt(III) Schiff base, and coordination complex
- Subject:
- Biology, Biochemistry, and Neurosciences
- Creator:
- Roberts, Kaleigh Filisa
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2018-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_773649 and http://dissertations.umi.com/northwestern:15349
-
- Description:
- Nearly all animals exhibit behaviors that can be classified as sleep. The distinctly disadvantageous nature of the asleep state, evolutionarily speaking, accentuates its role as a critical physiological process, yet chronic inadequate sleep is prevalent in today’s society. Among the multitude of health problems that have been linked to chronic...
- Keyword:
- Metabolome, Stress, Sleep, Sleep Deprivation, Microbiome, and PTSD
- Subject:
- Biology and Neurosciences
- Creator:
- Bowers, Samuel James
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15162 and etdadmin_upload_749831
-
- Description:
- Basal ganglia are a highly interconnected group of nuclei involved in motor control. The external globus pallidus (GPe) is a critical node within the basal ganglia circuit. While the prevailing basal ganglia circuit model assumes the GPe as merely a relay, phasic changes in the activity of GPe neurons during...
- Subject:
- Neurosciences
- Creator:
- Pamukcu, Arin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_770344 and http://dissertations.umi.com/northwestern:15325
-
- Description:
- Approximately 80-90% of individuals with Parkinson’s disease (PD) develop motor speech impairments, predominantly in the form of voice dysfunction. It is known that the motor symptoms of PD arise from degeneration of the dopamine producing neurons in the substantia nigra and dysregulation of basal ganglia motor pathways. It is also...
- Keyword:
- neuroimaging, dysarthria, fMRI, basal ganglia, hypophonia, and Parkinson's disease
- Subject:
- Neurosciences and Communication
- Creator:
- Manes, Jordan Leigh
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_759611 and http://dissertations.umi.com/northwestern:15211
-
- Description:
- Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimer’s disease (AD); however, little is known about the early mechanisms that contribute to this process. To objectively assess protein turnover at early stages of amyloid beta (Aβ) proteotoxicity, we used dynamic metabolic labeling with stable isotopes followed by proteomic...
- Keyword:
- Synaptic Vesicles, Alzheimer's Disease, Presynapse, Proteomics, and Protein Degradation
- Subject:
- Neurosciences
- Creator:
- Hark, Timothy
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15385 and etdadmin_upload_780177
-
- Description:
- The hippocampus has a well-established role in episodic memory and serves as a hub in a network of distributed brain regions (i.e., hippocampal-cortical network; HCN). Theta-band (4-8 Hz) neural activity recorded in the hippocampus have been associated with memory processing, and synchronized theta oscillations among the hippocampus and HCN regions...
- Subject:
- Neurosciences
- Creator:
- Hermiller, Molly Suzanne
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15271 and etdadmin_upload_764537
-
- Description:
- Neural stem and progenitor cell (NPC) fate specification is a crucial component of central nervous system development, and the myriad signaling pathways that guide it are poorly understood. In my thesis work, I aimed to elucidate signaling mechanisms of the bone morphogenetic protein family (BMP) and some of its targets...
- Keyword:
- YAP, Integrin, neural stem cell, TAZ, BMP, and HtrA1
- Subject:
- Neurosciences
- Creator:
- Chen, Jessie
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15191 and etdadmin_upload_755327
-
- Description:
- Melanopsin-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs) represent a class of non-canonical, ganglion cell photoreceptors. These cells influence a variety of visual behaviors including contrast sensitivity, circadian photoentrainment, sleep, and even mood. These wide-ranging behavioral influences are attributed to the multiple subtypes (M1-6) that comprise the ipRGC population, with different...
- Keyword:
- Development, ipRGCs, Melanopsin, and Retina
- Subject:
- Neurosciences and Developmental biology
- Creator:
- Lucas, Jasmine Ashley
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_744013 and http://dissertations.umi.com/northwestern:15132
-
- Description:
- We present two ways in which measures of information can be used for the design and analysis of neural networks in both the brain and the computer. In the brain, stimulus is often represented as a distributed pattern of activity in a network of neurons. The quality of such population...
- Keyword:
- Neural Coding, Fisher Information, Memory, Neural Networks, Population Coding, and Information Theory
- Subject:
- Artificial intelligence, Neurosciences, and Biophysics
- Creator:
- Kim, Hyun Jin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_764291 and http://dissertations.umi.com/northwestern:15264
-
- Description:
- Decisions in naturalistic environments usually feature delayed and uncertain outcomes that can only be reached after a sequence of actions are performed. For example, canonical stalking and pursuit strategies used by terrestrial predators often involve stages of concealment, pauses where the predator remains motionless, and high speed chase sequences. The...
- Keyword:
- Ecology, Evolution, Decision Making, and Computational Neuroscience
- Subject:
- Ecology, Biomedical engineering, and Neurosciences
- Creator:
- Mugan, Ugurcan
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_769384 and http://dissertations.umi.com/northwestern:15318
-
- Description:
- Classical conditioning is a form of associative learning and can be used as a behavioral paradigm to model and investigate the neural mechanisms underlying associative learning. In this work, classical conditioning paradigms are used to test the effectiveness of a disease model on the impact of learning and emotional regulation...
- Keyword:
- Memory, Persistent Firing, Entorhinal Cortex, Aging, Learning, and Postburst Afterhyperpolarization
- Subject:
- Neurosciences
- Creator:
- Lin, Carmen
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15321 and etdadmin_upload_770003
-
- Description:
- Navigating through the world is typically a multisensory experience. Mammals are believed to navigate using a cognitive map of space stored in the hippocampus. Yet, it is unclear how and whether spatial information of different sensory modalities can contribute to this map. A major barrier to addressing this question has...
- Keyword:
- Vision, 2-photon calcium imaging, Spatial perception, Olfaction, Smellevision, and Spatial cognition
- Subject:
- Cognitive psychology, Behavioral sciences, and Neurosciences
- Creator:
- Radvansky, Brad Allen
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/01/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15322 and etdadmin_upload_770028
-
- Description:
- Movement and sensing fundamentally works in a synergistic manner. Animal's sensory organs --- be they independently movable like eyes or requiring whole body movement as in the case of electroreceptors --- are actively manipulated throughout stimulus-driven active sensing behaviors. Though these sensing-related motions have been individually reported and analyzed across...
- Keyword:
- behavior, uncertainty, Shannon-Weaver entropy, exploration-exploitation tradeoff, active sensing, and information theory
- Subject:
- Artificial intelligence, Neurosciences, and Engineering
- Creator:
- Chen, Chen
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2019-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_675222 and http://dissertations.umi.com/northwestern:14742
-
- Description:
- A one-time, unilateral injury to the developing brain can interrupt the typical process of development and result in motor impairments that evolve over the course of the whole life-span. The timing of injury relative to neural development has implications for the continued refinement of the nervous system and the descending...
- Keyword:
- mirror movement, cerebral palsy, corticospinal tract, reaching, pediatric hemiplegia, and flexion synergy
- Subject:
- Biomedical engineering and Neurosciences
- Creator:
- Hill, Nayo Marel
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_792769 and http://dissertations.umi.com/northwestern:15452
-
- Description:
- Research on how sleep contributes to memory has blossomed in recent years. These studies have generally focused on whether or not sleep impacts various types of memory independently. An open question is whether sleep interactively influences different memory types. My research focuses on two types of memory—specificity and generalization. Whereas...
- Keyword:
- memory, sleep, generalization, memory consolidation, and targeted memory reactivation
- Subject:
- Cognitive psychology, Psychobiology, and Neurosciences
- Creator:
- Witkowski, Sarah (Sadie)
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2020-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15250 and etdadmin_upload_763727
-
- Description:
- The exchange of information in the brain is accomplished through sequences of action potentials that result from the integration of local microcircuits. Unraveling the connectivity of the neurons that constitute these microcircuits and how they contribute to network activity is vital for understanding how information is relayed through the brain...
- Subject:
- Neurosciences
- Creator:
- Fiske, Michael Patrick
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15476 and etdadmin_upload_797275
-
- Description:
- In the vertebrate retina, neurons process visual signals, generating feature selectivity in their activity levels. We use computational models to understand these behaviors by interpreting them mathematically. One component of this analysis is the spatial selectivity or receptive field, a property found in all visual sensory neurons. The neurons found...
- Keyword:
- Vision, Neuron, and Retina
- Subject:
- Neurosciences
- Creator:
- Cooler, Sam
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 04/15/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15450 and etdadmin_upload_792568
-
- Description:
- We present a biophysical model of GCaMP6f calcium fluorescence in CA1 pyramidal neuron dendrites based upon results from imaging and electrophysiology experiments. This work was completed using experimental results from the laboratory of Professor Daniel Dombeck, Department of Neurobiology. Constraining the model to reproduce different objectives --- from in-vitro and...
- Keyword:
- Calcium Model, Dendritic Spines, Computational Neuroscience, Calcium Imaging, and Synaptic Integration
- Subject:
- Applied mathematics and Neurosciences
- Creator:
- Young, Brita Schneiders
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_819855 and http://dissertations.umi.com/northwestern:15589
-
- Description:
- Understanding associative memory is fundamental for a variety of neurological and neurodegenerative diseases, however, a large proportion of this research has excluded female subjects due to unsubstantiated bias. By including intact females, ovariectomized females and males in the study of associative memory, clear sex differences in acquisition emerged. Female mice...
- Subject:
- Neurosciences
- Creator:
- Rapp, Amy
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_802347 and http://dissertations.umi.com/northwestern:15501
-
- Description:
- Prions are self-perpetuating, alternative protein conformations associated with neurological diseases and normal cellular functions. Saccharomyces cerevisiae contains many endogenous prions – providing a powerful system to study prionization. Previously, the Li Lab demonstrated that Swi1, a component of the SWI/SNF chromatin-remodeling complex, can form the prion [SWI+]. A small region,...
- Keyword:
- [SWI+], yeast, protein aggregation, prions, Saccharomyces cerevisiae, and Swi1
- Subject:
- Molecular biology, Bioinformatics, and Neurosciences
- Creator:
- Goncharoff, Dustin Kenneth
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_816388 and http://dissertations.umi.com/northwestern:15538
-
- Description:
- Astrocytes are the most abundant cell type in the brain, yet the mechanisms involved in astrocyte differentiation and the level of astrocyte heterogeneity in the CNS, particularly in the human cortex, is largely unknown due to the lack of subtype-specific astrocyte markers and inaccessibility of human brain tissue. Here we...
- Keyword:
- Glioblastoma, Stem cells, and Astrocyte
- Subject:
- Neurosciences
- Creator:
- Van Gulden, Stephanie
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15549 and etdadmin_upload_817717
-
- Description:
- Coiled-coil helix coiled-coil helix domain containing 10 (CHCHD10) is a nuclear gene that encodes for a mitochondria-enriched protein of unknown function. This type of protein is typically imported into mitochondria via the disulfide relay system which facilitates the formation of disulfide bridges between each coiled-coil helix, resulting in maintenance of...
- Subject:
- Neurosciences
- Creator:
- Ryan, Éanna B.
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_799720 and http://dissertations.umi.com/northwestern:15495
-
- Description:
- Understanding associative memory is fundamental for a variety of neurological and neurodegenerative diseases, however, a large proportion of this research has excluded female subjects due to unsubstantiated bias. By including intact females, ovariectomized females and males in the study of associative memory, clear sex differences in acquisition emerged. Female mice...
- Subject:
- Neurosciences
- Creator:
- Rapp, Amy
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/28/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_802347 and http://dissertations.umi.com/northwestern:15501
-
- Description:
- Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by motor neuron (MN) degeneration and resulting in progressive paralysis and death. ALS is genetically heterogeneous, disease pathophysiology is not completely understood, and there are no effective drug therapies. To develop broadly applicable therapeutics, we examine disease mechanisms in the...
- Keyword:
- ALS, C9orf72, iPSCs, nucleocytoplasmic transport, NEK1, and microtubules
- Subject:
- Molecular biology, Cellular biology, and Neurosciences
- Creator:
- Daley, Elizabeth
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15607 and etdadmin_upload_825395
-
- Description:
- Movement is achieved by combining synaptic inputs from various sources and activating motor unit populations. Motor units are the quantal elements of motor control which act as a neuromechanical transducer that converts sensory inputs into motor output. Because of the tight neuromuscular junctions between motoneuron axon terminals and a large...
- Keyword:
- Human Motor Control, EMG, Delta-F, Motor Units, and PICs
- Subject:
- Neurosciences
- Creator:
- Kim, Edward
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_824453 and http://dissertations.umi.com/northwestern:15604
-
- Description:
- Mitochondria-lysosome contacts are recently identified sites for mediating crosstalk between both organelles, but their role in normal and diseased human neurons remains unknown. We used super-resolution and live-cell microscopy in human iPSC-derived neurons to demonstrate that mitochondria-lysosome contacts can dynamically form in the soma, axons, and dendrites of human neurons,...
- Keyword:
- iPSC, Interorganelle contacts, GBA, Lysosome, Mitochondria, and Parkinson's disease
- Subject:
- Molecular biology, Cellular biology, and Neurosciences
- Creator:
- Kim, Soojin
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_825288 and http://dissertations.umi.com/northwestern:15606
-
- Description:
- Chemokines, such as Stromal Derived Factor 1 (SDF-1 or CXCL12) and their G protein coupled receptors (GPCRs) are well known regulators of the development and functions of numerous tissues. CXCL12 has two receptors: CXCR4 and CXCR7 or atypical chemokine receptor 3 (ACKR3). CXCR7 has been described as an atypical “biased”...
- Keyword:
- CXCR4 and CXCR7
- Subject:
- Pharmacology and Neurosciences
- Creator:
- Hopkins, Brittany E
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15737 and etdadmin_upload_844430
-
- Description:
- Coordinated movement relies on the precise and controlled activation of populations of motor units, which convert the commands of the nervous system into muscle forces. Motor unit firing patterns are often nonlinear and generated through the response to a combination of ionotropic excitatory and inhibitory commands, as well as metabotropic...
- Keyword:
- Motor Unit, Stroke, Persistent Inward Currents, Delta-F, Motoneuron, and Aging
- Subject:
- Biomedical engineering and Neurosciences
- Creator:
- Hassan, Altamash Shamsul
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15718 and etdadmin_upload_843639
-
- Description:
- Processing of sensory information in the brain is a pervasive and fundamental phenomenon across animal species and is involved in both "hard-wired" innate responses as well as learned and adaptive behaviors. Here, I show that the avoidance of hot temperature, a simple innate behavior, contains unexpected plasticity and complex processing...
- Keyword:
- systems neuroscience, sensory navigation, modeling, drosophila, thermosensation, and neural circuits
- Subject:
- Applied mathematics, Biology, and Neurosciences
- Creator:
- Levy, Joshua
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_836701 and http://dissertations.umi.com/northwestern:15663
-
- Description:
- Inter-organelle contact sites have become increasingly appreciated as important regulators of cellular homeostasis, and disruption of inter-organelle contact site dynamics and function has been observed in various pathologies. Recently, inter-organelle contact sites between mitochondria and lysosomes were discovered, offering a new mechanism by which these two organelles may directly interact,...
- Keyword:
- Imaging, Contact Sites, Lysosome, Mitochondria, Neurological Disease, and Calcium
- Subject:
- Biology, Medicine, and Neurosciences
- Creator:
- Peng, Wesley J
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 10/07/2021
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15610 and etdadmin_upload_827420
-
- Description:
- Social engagement, or shared attention between a child and caregiver, is a critical process for language and social development. Although previous EEG studies have investigated child social processing in closely controlled, experimental studies, no study has examined the interactive, reciprocal process of naturalistic social engagement. In my first paper, we...
- Subject:
- Developmental psychology and Neurosciences
- Creator:
- Manning, Brittany L
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15820 and etdadmin_upload_855920
-
- Description:
- In memory overgeneralization, details from negatively-valenced episodic memories become excessively generalized to unrelated neutral situations. This is a key cognitive distortion associated with major depressive disorder (MDD), generalized anxiety disorder (GAD), and post-traumatic stress disorder (PTSD). Stress promotes memory generalization, and this process likely relies on stress-induced changes in dorsal...
- Subject:
- Neurosciences
- Creator:
- Ren, Lynn Yi
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_851720 and http://dissertations.umi.com/northwestern:15800
-
- Description:
- Stimulus generalization is a critical mechanism for facilitating behavioral flexibility. Generalization allows the brain to reduce computational demands that would otherwise be necessary to create unique representations for each and every encounter while allowing the ability to deal with the complexity of real-world situations. Stimulus generalization is a fundamental cognitive...
- Keyword:
- discrimination learning, olfactory generalization, peak shift, fMRI, and aversive outcomes
- Subject:
- Neurosciences
- Creator:
- Porter, Daria Boratyn
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_777969 and http://dissertations.umi.com/northwestern:15368
-
- Description:
- The dentate gyrus is the first region for information processing within the classic hippocampal trisynaptic circuit, and this position makes it an important structure for the formation of associative memories. The dentate gyrus contains two major types of excitatory neurons: granule cells and mossy cells. While previous work has shown...
- Subject:
- Neurosciences
- Creator:
- Miller, Lisa
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_861456 and http://dissertations.umi.com/northwestern:15850
-
- Description:
- Protein homeostasis, or proteostasis, is essential for preserving all cellular functions and involves a balance of protein synthesis, folding, trafficking, and degradation. A collapse in proteostasis is a common feature of many neurodegenerative disorders that are characterized by the accumulation of insoluble protein aggregates in the brain. Parkinson’s disease (PD)...
- Keyword:
- induced pluripotent stem cell models, ER stress, protein aggregation, protein folding, and lysosomal dysfunction
- Subject:
- Molecular biology and Neurosciences
- Creator:
- Stojkovska, Iva
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 02/02/2022
- Date Created:
- 2021-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_850723 and http://dissertations.umi.com/northwestern:15793
-
- Description:
- In the adult hippocampus of many mammalian species, populations of newborn dentate granule cells (DGCs) are continuously generated and undergo subsequent activity-dependent neuronal maturation and incorporation into the preexisting hippocampal circuitry. Increasing evidence has demonstrated that these young adult-born DGCs (abDGCs) participate in numerous cognitive and affective processes such as...
- Keyword:
- Neurogenesis, GABA, Adult-born granule cell, Kainate receptor, and GluK2
- Subject:
- Neurosciences
- Creator:
- Zhu, Yiwen
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15903 and etdadmin_upload_874789
-
- Description:
- My research at northwestern with Dr. Christina Zelano focused on the human amygdala subnucleithat receive monosynaptic input from the olfactory bulb. Surprisingly little is known about these brain regions, including their potential roles in olfactory and nonolfactory processing. During my PhD, I completed three projects aimed at furthering our understanding...
- Keyword:
- Breathing, Olfaction, Respiration, Amygdala, and Human
- Subject:
- Neurosciences
- Creator:
- Noto, Torben
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16080 and etdadmin_upload_902927
-
- Description:
- Anxiety and depression are highly prevalent, recurrent, and major public health problems. Decades of research has uncovered associations between symptom dimensions of anxiety and depression and abnormal neural activation across executive control-, threat-, and reward-related networks. Recent studies have developed a hierarchical symptom structure of anxiety and depression termed the...
- Keyword:
- Executive Control, Reward, EEG, Threat, Anxiety, and Depression
- Subject:
- Physiology, Psychology, and Neurosciences
- Creator:
- Glazer, James
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_903824 and http://dissertations.umi.com/northwestern:16106
-
- Description:
- Background: The way in which one perceives their visual world (i.e., bottom-up visual perception) and what one pays attention to in their surroundings (i.e., top-down attention), are critical to uncovering underlying thoughts and cognitions, and impact how one operates in the social world. Individuals with autism spectrum disorder (ASD), a...
- Keyword:
- Eye tracking, Broad Autism Phenotype, Autism, Endophenotype, Local Global Processing, and EEG/ERP
- Subject:
- Cognitive psychology, Psychobiology, and Neurosciences
- Creator:
- Nayar, Kritika
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_898041 and http://dissertations.umi.com/northwestern:16008
-
- Description:
- Herpes simplex virus (HSV) encephalitis (HSE) is the most common cause of sporadic fatal encephalitis, and despite targeted antiviral therapy, outcomes remain poor. While rare in adults, neonates are significantly more susceptible to severe HSV disease. Understanding both the host and viral factors that contribute to pathogenesis is critical to...
- Keyword:
- Inflammasome, Neonate, Encephalitis, and Herpes
- Subject:
- Virology, Immunology, and Neurosciences
- Creator:
- Hayes, Cooper Kincaid
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_903123 and http://dissertations.umi.com/northwestern:16088
-
- Description:
- The retina does not act as a simple camera, rather visual information goes through multiple layers of processing before it reaches the brain. Retinal ganglion cells (RGCs) are the output neurons of the retina and process visual information in the retina and then project into the brain. There are over...
- Keyword:
- Vision, Retinal ganglion cells, Neuroscience, and Retina
- Subject:
- Neurosciences
- Creator:
- Wienbar, Sophia Rose
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16017 and etdadmin_upload_898849
-
- Description:
- All animals purposefully navigate feature-rich environments: while exploring, in search of vital resources of food and water, finding mates, and patrolling and marking habitats. During these complex behaviors, continuous analogue input information from peripheral sensory organs guides discrete and digital sequential motor output; accordingly, each action is informed, modulated, or...
- Keyword:
- Rodent, Behavior, Trigeminal, Prrxl1, Somatotopy, and Ingestive
- Subject:
- Neurosciences
- Creator:
- Resulaj, Admir
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_879817 and http://dissertations.umi.com/northwestern:15946
-
- Description:
- The cerebellar cortical system is an extensively studied circuit which is critical for motor learning. While multiple monoamines, such as norepinephrine and serotonin, modulate cerebellar cortical output, the mechanistic details of dopaminergic signaling in the cerebellum remain poorly understood. Additionally, neuronal cell types residing within the cerebellum remain relatively under-characterized....
- Keyword:
- Cerebellum, Dopamine, Unipolar brush cells, and Light sheet microscope
- Subject:
- Neurosciences
- Creator:
- Canton-Josh, Jose Ernesto
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15996 and etdadmin_upload_896041
-
- Description:
- Glioblastoma multiforme (GBM) is the most prevalent primary central nervous system tumor, characterized by resistance to therapeutic intervention, inevitable recurrence, and ultimately patient death. The dismal prognosis is due in part to underlying molecular factors that promote an intratumoral cellular state heterogeneity and protect tumor cells from cell death pathways....
- Keyword:
- Ferroptosis, Glioblastoma, Cancer, Stemness, Metabolism, and IDH1
- Subject:
- Molecular biology, Medicine, and Neurosciences
- Creator:
- Murnan, Kevin Michael
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15885 and etdadmin_upload_865864
-
- Description:
- Numerous insights into the sensorimotor systems that guide the control of voice have been garnered by observing how the system responds to manipulations of its auditory feedback. However, current approaches may be limited in the exploration of more complex parameters of volitional and adaptive voice control due to their limited...
- Keyword:
- Auditory Feedback, Sensorimotor Neuroscience, Systems and Cognitive Neuroscience, Speech Motor Control, Attention and Working Memory, and Vocal Control
- Subject:
- Cognitive psychology and Neurosciences
- Creator:
- Kim, Jason H
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:15952 and etdadmin_upload_882078
-
- Description:
- Sensorimotor integration is a general term to describe how task-specific motor output is generated from the selective and rapid processing of sensory and motor information. The rodent vibrissal (whisker) system is an important model for the study of sensorimotor integration and active tactile sensing. This research uses the rodent vibrissal...
- Keyword:
- whisker, multi-whisker responses, trigeminal brainstem, vibrissa, multivibrissal stimulation, and tactile
- Subject:
- Neurosciences
- Creator:
- Dorizan, Schnaude
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 06/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_879050 and http://dissertations.umi.com/northwestern:15928
-
- Description:
- Electrical spinal cord stimulation is an emerging treatment for spinal cord injury that can improve walking and bladder control, among many other functions. While the anatomical location of the motor pools for muscles involved in locomotion in the lumbosacral cord has been identified, the map of the functional output of...
- Subject:
- Neurosciences
- Creator:
- Patterson, Jacqueline
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16163 and etdadmin_upload_917878
-
- Description:
- The current view in neuroscience holds that the brain, together with its sensory and motor structures and the environment, form a closed-loop system – a sensorimotor loop – in which the brain receives information from the environment and converts it into a motor response while simultaneously making predictions about future...
- Subject:
- Biomedical engineering, Computer science, and Neurosciences
- Creator:
- Zweifel, Nadina Olivia
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16198 and etdadmin_upload_925059
-
- Description:
- Affect represents a major domain of human consciousness, consisting of a complex group of psychophysiological processes to drive human behavior. Many genetic and environmental factors may cause dysregulation of affective states, resulting in disorders that severely disrupt normal cognitive function and diminish the quality of life. Transitions among affective states...
- Keyword:
- Dopamine, Optogenetics, and Affective disorders
- Subject:
- Neurosciences
- Creator:
- Wu, Mingzheng
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_925290 and http://dissertations.umi.com/northwestern:16201
-
- Description:
- Cholinergic modulation of the brain cortex is critical for cognitive processes, and altered cholinergic modulation of the prefrontal cortex is emerging as an important mechanism of neuropathic pain. Despite the known sex differences in pain prevalence and perception, the precise nature of the mechanisms responsible for sexual dimorphism in chronic...
- Keyword:
- acetylcholine, cholinergic modulation, prefrontal cortex, and pain
- Subject:
- Neurosciences
- Creator:
- Jefferson, Taylor
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- http://dissertations.umi.com/northwestern:16249 and etdadmin_upload_928522
-
- Description:
- Persons with spinal cord injuries can use state-of-the-art brain-computer interfaces to control robotic arms. Despite this high-tech solution, their movements are slow and imprecise, much like those made by individuals who have lost proprioception, the sense of body position and movement. Intracortical microstimulation (ICMS) used to reactivate neural circuits in...
- Keyword:
- proprioception, stimulation, prosthetic, and sensory
- Subject:
- Biomedical engineering and Neurosciences
- Creator:
- Sombeck, Joseph T
- Owner:
- Scholarly Digital Publishing
- Language:
- en
- Date Uploaded:
- 09/22/2022
- Date Created:
- 2022-01-01
- Resource Type:
- Dissertation
- Alternate Identifier:
- etdadmin_upload_917097 and http://dissertations.umi.com/northwestern:16157