Patients with sickle cell disease (SCD) experience lifelong struggles with both chronic and acute pain, often requiring medical intervention. Pain can be managed with medications, but dosages must balance the goal of pain mitigation against the risks of tolerance, addiction and other adverse effects. Setting appropriate dosages requires knowledge of...
Metabolic conditions affect the developmental tempo of most animal species. Consequently, developmental gene regulatory networks (GRNs) must faithfully adjust their dynamics to a variable time scale. We find evidence that weak repressors of gene expression provide the necessary coupling between GRN output and cellular metabolism. Using a mathematical model that...
Spatiotemporal dynamics of EEG/MEG (electro-/magneto-encephalogram) have typically been investigated by applying time-frequency decomposition and examining amplitude-amplitude, phase-phase, or phase-amplitude associations between combinations of frequency bands and scalp sites, primarily to identify neural correlates of behaviors and traits. Instead, we directly extracted global EEG spatiotemporal dynamics as trajectories of k-dimensional state...
In the early decades of the NAES College library, librarians kept a physical card catalog which described, organized, and made findable all of the materials faculty, students, staff, and their relations might need as part of their experience at the college. Representing a unique view of the library in the...
Soil texture has important ramifications on the shape and size of roots as well as impacting how much water is taken up and the distribution of nutrients in the soil. These factors lead to differences in growth characteristics and plant performance. However, what traits and how the plant responds to...
There is growing evidence that growth with invasive species influences the traits of co-occurring native plants over multiple generations. Some studies indicate that these experienced populations perform better in the presence of the invasive species that led to the trait changes. These experienced populations could serve as source material for...
Understanding how root traits vary within a species and how traits respond to heterogeneous environments, can provide important insight into functional plant attributes that influence plant survival in competitive environments. Selecting plant material with root traits that will support its survival in heterogenous environments may help improve the outcomes of...
Restoration practitioners have many seed material choices when restoring plant communities, and for some species, cultivars may be the most affordable and accessible material available. However, the process of plant selection and commercial seed production can limit trait variability critical to survival and persistence in heterogeneous environments. Several studies have...
The custom of voluntarily tipping for services rendered has gone in and out of fashion in America since its introduction in the 19th century. Restaurant owners that ban tipping in their establishments often claim that social justice drives their decisions, but we show that rational profit-maximization may also justify the...
Advances in biosensor engineering have enabled the design of programmable molecular systems to detect a range of pathogens, nucleic acids, and chemicals. Here, we engineer and field-test a biosensor for fluoride, a major groundwater contaminant of global concern. The sensor consists of a cell-free system containing a DNA template that...
In many dryland environments, vegetation self-organizes into bands that can be clearly identified in remotely-sensed imagery. The status of individual bands can be tracked over time, allowing for a detailed remote analysis of how human populations affect the vital balance of dryland ecosystems. In this study, we characterize vegetation change...
Recent advances in cell-free gene expression (CFE) systems have enabled their use for a host of synthetic biology applications, particularly for rapid prototyping of genetic circuits and biosensors. Despite the proliferation of cell-free protein synthesis platforms, the large number of currently existing protocols for making CFE extracts muddles the collective...
A longstanding goal of synthetic biology has been the programmable control of cellular functions. Central to this is the creation of versatile regulatory toolsets that allow for programmable control of gene expression. Of the many regulatory molecules available, RNA regulators offer the intriguing possibility of de novo design – allowing...
These files include source datasets for the article "Multipartite stabilization of the C. beijerincki pfl ZTP aptamer disfavors terminator hairpin folding by gating strand invasion". RELATED ARTICLE: Strobel, E.J., Cheng, L., Berman, K.E. et al. A ligand-gated strand displacement mechanism for ZTP riboswitch transcription control. Nat Chem Biol 15, 1067–1076...
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The analysis of citations to scientific publications has become a tool in the evaluation of a researcher’s work, especially due to an ever-increasing production volume. Despite its acknowledged shortcomings and the ongoing debate on their meaning, citations are still primarily viewed as endorsements and as indicators of the...
Related article: McGrath, M.C., Gerber, A.S. Experimental evidence for a pure collaboration effect. Nat Hum Behav 3, 354–360 (2019) doi:10.1038/s41562-019-0530-9
This file contains the supplementary online material that should accompany the paper "Defining and Measuring the Influences of GIS-Based
Instruction on Students’ STEM-Relevant Reasoning", published in Journal of Geography.
This dissertation provides a study of local Black media development in Detroit in the decade following the 1967 Rebellion, as Detroit became a majority Black city. I argue that Black Detroiters not only produced documentaries that challenged local white discourse within what George Lipsitz terms “a Black spatial imaginary,†but...
Reactive Nitrogen (N) and phosphorus (P) pollution is responsible for a vast array of environmental problems, including eutrophication of nutrient limited water bodies, vast dead zones in the ocean margins, and ammonia toxicity to aquatic life. N pollution is also linked to the emission of the potent greenhouse gas nitrous...
Importance: Despite its efficacy, low tidal volume ventilation (LTVV) remains severely underutilized for patients with acute respiratory distress syndrome (ARDS). Physician under-recognition of ARDS is a significant barrier to LTVV use. We propose a computational method that addresses some of the limitations of the current approaches to automated measurement of...
To aid in the successful execution of goal-directed walking (discrete movement from a start location to an end target) the central nervous system forms a predictive motor plan. For the motor plan to be effective, it must be adapted in response to environmental changes. Despite motor planning being inherent to...
Data files for the Chicago Historical Homicide Project. The Chicago Historical Homicide Project began with the discovery of the availability of a rich log of more than 11,000 homicides maintained consistently and without interruption by the Chicago Police Department over the course of 60 years, from 1870 to 1930. The...
In May 2018, the US Food and Drug Administration approved daily oral pre-exposure prophylaxis (PrEP) for adolescents under age 18. Although this is an important step toward HIV prevention for adolescents assigned male at birth who have sex with males (AMSM), limited research exists to gauge their awareness of PrEP...
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Socially relevant situations that involve strategic interactions are widespread among animals and humans alike. To study these situations, theoretical and experimental research has adopted a game theoretical perspective, generating valuable insights about human behavior. However, most of the results reported so far have been obtained from a population...
The ideology scores of US Congress members over time, quantified from how similarly they voted on bills. I present an interactive visualization for the US Congress members’ ideology. The data used are ideology scores of US Congress members 1789-2015. The ideology scores are quantified from the Congress members’ voting records...
Traditional bottom-up mass spectrometry-based proteomics relies on the use of an enzyme, often trypsin, to generate small peptides (typically < 25 amino acids long). In top-down proteomics, proteins remain intact and are directly measured within the mass spectrometer. This technique, while inherently simpler than bottom-up proteomics, generates data which must...
Nearly a quarter of visits to the Emergency Department are for conditions that could have been managed via outpatient treatment; improvements that allow patients to quickly recognize and receive appropriate treatment are crucial. The growing popularity of mobile technology creates new opportunities for real-time adaptive medical intervention, and the simultaneous...
These datasets include all raw data, corrected data, and correction calculations for the sapling height, statistical tests and mycorrhizal morphological analysis data analyzed during the experimental work.
This collection includes all of the supplemental figures that were not included in the thesis document. (Isotopic, Mycorrhizal Morphology and Temperature)