An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative and links to the open-access version can be found at... and Perception in Aristotle's Ethics seeks to demonstrate that living an ethical life requires a mode of perception that is best called ethical perception. Specifically, drawing primarily on Aristotle’s accounts of perception and ethics in De anima and Nicomachean Ethics, Eve Rabinoff argues that the faculty of perception (aisthesis), which is...
Cite this article: Shen, J., McFarland, A.G., Blaustein, R.A. et al. An improved workflow for accurate and robust healthcare environmental surveillance using metagenomics. Microbiome 10, 206 (2022). https://doi.org/10.1186/s40168-022-01412-x and Background: Effective surveillance of microbial communities in the healthcare environment is increasingly important in infection prevention. Metagenomics-based techniques are promising due to their untargeted nature but are currently challenged by several limitations: (1) they are not powerful enough to extract valid signals out of the background noise for low-biomass samples,...
An electronic version of this book is freely available, thanks to the support of libraries working with Knowledge Unlatched. KU is a collaborative initiative designed to make high-quality books open access for the public good. More information about the initiative can be found at www.knowledgeunlatched.org. and Will the future be one of economic expansion, greater tolerance, liberating inventions, and longer, happier lives? Or do we face economic stagnation, declining quality of life, and a technologically enhanced totalitarianism worse than any yet seen? The Fabulous Future? America and the World in 2040 draws its inspiration from a...
This book is freely available in an open access edition thanks to TOME (Toward an Open Monograph Ecosystem)—a collaboration of the Association of American Universities, the Association of University Presses, and the Association of Research Libraries—and the generous support of the Pennsylvania State University. Learn more at the TOME website,... and This book investigates what change is, according to Aristotle, and how it affects his conception of being. Mark Sentesy argues that change leads Aristotle to develop first-order metaphysical concepts such as matter, potency, actuality, sources of being, and the teleology of emerging things. He shows that Aristotle’s distinctive ontological claim—that...
Advances in biosensor engineering have enabled the design of programmable molecular systems to detect a range of pathogens, nucleic acids, and chemicals. Here, we engineer and field-test a biosensor for fluoride, a major groundwater contaminant of global concern. The sensor consists of a cell-free system containing a DNA template that...
Recent advances in cell-free gene expression (CFE) systems have enabled their use for a host of synthetic biology applications, particularly for rapid prototyping of genetic circuits and biosensors. Despite the proliferation of cell-free protein synthesis platforms, the large number of currently existing protocols for making CFE extracts muddles the collective...
A longstanding goal of synthetic biology has been the programmable control of cellular functions. Central to this is the creation of versatile regulatory toolsets that allow for programmable control of gene expression. Of the many regulatory molecules available, RNA regulators offer the intriguing possibility of de novo design – allowing...
The segmental prestressed concrete box girder of Koror-Babeldaob (KB) Bridge in Palau, which had the record span of 241 m (791 ft.), presents a striking paradigm of serviceability loss due to excessive multi-decade deflections. The data required for analysis have recently been released and are here exploited to show how...
This thesis consists of the data and analysis of structural responses for two different studies: the Office of Surface Mining (OSM) study of the velocity response of “atypical” residential structures and the Autonomous Crack Monitoring (ACM) study. The main basis of this thesis was to do additional analysis on a...