The current research tested the principles of role congruity theory of prejudice, which states that prejudice arises from an incongruity between a group stereotype and social role characteristics (i.e., the attributes and behaviors prescribed by the social role), such that prejudice occurs when members of a group enter or attempt...
Studies on consolidated democracies have long concluded that there is a positive relationship between socioeconomic status and turnout. The strength of the empirical findings that linked electoral participation to socioeconomic variables elevated this correlation to a law-like principle and made it possible to assume that this electoral behavior would prevail...
This dissertation is a study of the figure of the intruder in postcolonial francophone literature, film and graphic novels published and released in the second half of the 20th and early 21st century which develop a discourse on the Maghreb or the Maghrebian dispora in France. Postcolonial critics have long...
This study examines the intersection between art and politics in the salons of Les XX, a group of some twenty, mostly Belgian, artists organizing international exhibitions of art in Brussels, Belgium between 1884 and 1893. The fact that Les XX derived a significant base of support from some of the...
Anthony Braxton’s Trillium J, part of an ambitious planned “complex” of 36 one-act operas, premiered in 2014. Very little writing—anecdotal, journalistic, nor scholarly—exists on these works, so this research provides a critical introduction, contextualizing the operas within Braxton’s oeuvre and discussing the works’ fundamental musical materials and organization.
Examples from...
The emergence of lightwave communication and computing, and applications in nanophotonics require an understanding of complex electromagnetic wave phenomena in linear and nonlinear materials having frequency-dependent and intensity-dependent polarizations. Both the complexity of the underlying physics and the problems required for modern engineering applications necessitate understanding the vector-nature of the...
The combined trends of decreasing application size and increasing requirements for energy efficiency have driven a need for improved understanding and better predictive tools for thin film lubricated systems. Research on such systems is complicated by the involvement of both larger scale phenomena such as fluid flow, material deformation, and...
Although recent research has provided some evidence to suggest that positive mood is associated with increased interpersonal trust, our understanding of the underlying explanation for why this occurs is far from complete. The current project presents the results from 4 experiments which were designed to understand both when, and why,...
My work in Comparative Literary Studies and French explores the link between the Mande oral tradition and its literature to reveal the presence and absence of the griots' words and their portrayal in the novel. Authors Amadou Hampaté Bâ (L'Étrange Destin de Wangrin); Massa Makan Diabaté (L'Assemblée de Djinns); D.T....
Polymers and polyelectrolytes are ideal tools for the development of novel self-assembled materials. The ability to control the length-scales of self-assembly, and thus the properties, for soft materials lies in the understanding and subsequent manipulation of competing intermolecular interactions, such as hydrophobicity, hydrogen bonding, van der Waals, electrostatics. In this...
The first chapter investigates the offshoring decision from a network capacity investment perspective. We analyze a firm that manufactures two products to serve two geographically separated markets using a common component and two localized final assemblies. Two strategic network design questions arise naturally: (1) Should the common part be produced...
Portfolio optimization problems with transaction costs have been widely studied by both financial economists and financial engineers through various approaches. In this paper, we propose the following approach. In analogy to American option pricing, we study the problem through the Finite Element Method (FEM) combined with an optimization method: We...
Organizational research has analyzed employee-organization relationships for years (Eisenberger, Fasolo, & Davis-LaMastro, 1990; Levinson, 1965; Tsui, Pearce, Porter, & Tripoli, 1997). However, the research on organizational citizenship behavior (OCB) has mainly focused upon antecedents and consequences of OCB attentive to organizational outcomes. This study extends OCB research to investigate OCB...
Novel self-healing alloy composites have been designed to address the need for self-repairable high-strength structural materials. A systems-based materials design approach using computational design tools was used to design a multifunctional biomimetic composite that can repair structural damage. The self-healing composite consists of a controlled-melting alloy matrix reinforced by thermodynamically...
The dependence of the electro-optic (EO) properties on the field-dependent domain structure in epitaxial polydomain BaTiO<sub>3</sub> thin films was investigated. Models of both the field-dependent electronic polarization and the EO response and their dependence on domain structure were developed. The agreement of these models with measured polarization and EO data...
Research suggests that there exists in some homosexual men a moral push towards the disclosure of their HIV serostatus; yet, does an antithetical, individualistic, and self-oriented movement that searches for restitution for HIV infection exist in others? The following study tested the influence of vengeance, hostility, anger, and other negative...
Youth with comorbid depression and conduct disorder (CD) in the juvenile justice system are a particularly vulnerable population. Comorbidity of depression and CD, as well as juvenile justice involvement, is associated independently with impairment and negative outcomes. Nevertheless, service provision to this high-need population is especially lacking. The purpose of...
This dissertation investigates the nature of apocalyptic fiction in the first Soviet decade. In my introduction, I consider the secondary or underground status that apocalyptic thought assumed during this period vis a vis the prevailing cultural ethos of utopianism. I assert that Russian literary apocalyptic persisted as a genre by...
The first essay examines how the shift between single-tasking and multitasking influences productivity and workers' bargaining power, and its implications on the distribution of earnings between management and workers. Under single-tasking, a firm can obtain high productivity because workers' hold-up power can provide them with larger incentives to work. In...
In high power density transmission systems, Ni-Co secondary hardening steels have shown great potential for next-generation gear applications due to their excellent strength, toughness and superior fatigue performance.
Study of residual stress generation and evolution in Ferrium C61 and C67 gear steels revealed that shot peening and laser peening processes...
This dissertation project explores the relationship between the architectures of black masculinity in America and a specific performance of discreet sexual identity. Through critical ethnographic and discursive exploration, I look closely at a group of black men who describe themselves as being on the "down low" (DL). These men, who...
Alzheimer's disease (AD) is a progressive amnestic dementia typified by the pathological self-association of the microtubule-associated tau protein into neurofibrillary tangles (NFTs). Important to NFT formation are numerous modifications of tau, including phosphorylation, truncation, and conformational changes. In addition, AD-associated inflammation promotes the formation of peroxynitrite (ONOO-), a potent nitrating...
Information has become increasingly important in modern organizations. It is frequently the form and function of work. Queries, novel information, facts and reports are used to complete tasks, coordinate interdependencies, and share knowledge. While information is critical to organizational and individual effectiveness, little is known about the mechanisms whereby information...
This dissertation analyzes the role of the Dutch city Middelburg around 1600 in stimulating the flower still-life production of Ambrosius Bosschaert. The shift in power from Antwerp to Amsterdam as the center of the northern European art market around 1600 has received much attention without recognition of the important role...
The enormous popularity of The Beggar's Opera gave rise to a remarkable series of plays known as ballad opera, a form that dominated the eighteenth-century London stage during the 1730s, a crucial decade in the development of English theatre. Although virtually every major playwright of the period, including Colley Cibber,...
This dissertation develops a war-centered theory of collectivist regimes. I argue that in a large-scale industrial war of coalition alliances, belligerent nations launch extensive programs of economic mobilization and establish centralized bureaucratic institutions of economic regulation. Because exterior states are likely to restrict interior states in their access to the...
FPGAs are evolving at a rapid pace with improved performance and logic density. However, power efficiency of FPGAs has continuously lagged behind, and hence power optimization of FPGAs is crucial. Trends in technology scaling makes leakage power a serious concern for designers; on the other hand, routing power is the...
Over the past two decades photonic crystals (PhCs) have emerged as a promising new class of materials which offers unprecedented control of light in materials. Recently, atomic layer deposition (ALD) has been shown to be a powerful tool for the infiltration of 3D templates with dielectric or semiconducting materials, which...
This is a detailed study of Congress's China policy, with a view toward building a theory of congressional policymaking. I argue that committees, bicameralism, and presidential veto have severely constrained Congress's ability to legislate on China policy. I analyze China bills introduced between 1973 and 2006. I report evidence that...
This dissertation analyzes the decision process of firms along two dimensions which are central to the field of macroeconomics. First, we study the pricing decision of the firm in a framework where customer base matters. Surveys of managers show that the main reason why firms keep prices stable is that...
Safe design requires a valid mechanical model and correct probabilistic analysis. Concrete, which is an archetypical quasibrittle material, typically exhibits stable crack propagation in many types of failure. Therefore, a scientific approach requires analyzing concrete failure on the basis of fracture mechanics. One of the simplest ways to incorporate fracture...
In the first essay, I examine the impact of exogenous changes in stock prices on managers' voluntary disclosures. Specifically, I investigate whether stock price declines prompt managers to voluntarily disclose firm-value-related information that was withheld prior to the decline because it was "unfavorable" but became favorable at a lower stock...
The work presented in this dissertation is centered on experimental efforts to maximize the sensitivity of surface-enhanced Raman spectroscopy (SERS) and tip-enhanced Raman spectroscopy (TERS) toward their application in ultrasensitive nanoscale chemical analysis. The work focuses on fundamental studies of the plasmonic properties of silver nanostructures, and how those properties...
Hegel's lectures on aesthetics bear witness not to the cessation of artistic activity as such, but to a progressive decline in its significance for human self-understanding. Still, the nature and extent of this decline remain contested. Is the creation of new art a vestigial activity in a world governed by...
The work presented here describes investigations into the optical properties of single silver nanoparticles. The contents of this thesis are divided into two parts: (1) single nanoparticle localized surface plasmon resonance (LSPR) spectroscopy and sensing and (2) approaches to combining LSPR spectroscopy with atomic force and transmission electron microscopies. Part...
Primary progressive aphasia (PPA) is a debilitating neurodegenerative syndrome that principally impairs the cognitive domain of language. Patients demonstrate deficits in a variety of language faculties including object naming (anomia), word finding, single word and sentence reading, speech comprehension, repetition, syntactic processing, and paraphasia. PPA has been associated with selective...
Breast cancer cells acquire many genetic alterations in apoptotic signaling pathways rendering them resistant to apoptosis. Human Epidermal growth factor Receptor-2 (HER-2/ErbB2/neu) is amplified or overexpressed in approximately 30% of breast and ovarian tumors and correlates with poor prognosis. Although HER-2 is an orphan receptor, it forms potent signaling heterodimers...
"Black Power TV: A Cultural History of Black Public Affairs Television, 1968-1980" chronicles the history of a television genre that emerged in 1968, addressing African American audiences with such bold titles as Like It Is, Say Brother, Our People, and For Blacks Only in cities such as Boston, New York,...
Nanoplasmonics is an emerging branch of photonics that studies the optical properties of noble metals. Nanostructured noble metal materials, which can strongly interact with light and support various plasmon modes, are exceptional candidates for nanophotonic devices. This work describes the latest advances in the fabrication of ordered silver nanoparticles or...
Intramuscular electromyograms (EMG) are believed to provide several potential advantages over surface EMG for multifunctional myoelectric prosthesis control. One example is the ability to focally record from deep muscles of the forearm. However, intramuscular EMG has rarely been investigated due to the inability to obtain chronic recordings. New technology is...
The response to reduced levels of oxygen (hypoxia) is essential for embryonic development by promoting the proper formation of vascular networks. Conversely, hypoxia also promotes the development of pathophysiological processes such as pulmonary hypertension and cancer. The main mediator of responses to hypoxia within the cell is the transcription factor...
The optimization problems associated with adaptive and autonomic computing systems are often difficult to pose well and solve efficiently. A key challenge is that for many applications, particularly interactive applications, the user or developer is unlikely or unable to provide either the objective function f, or constraints. It is a...
Oxide surface structures play a key role in many technological processes, including catalysis, thin film growth, and layered structures, and a thorough understanding of surface structures and surface structure dynamics is required in order to better engineer materials systems for these processes. This research works towards understanding these fundamental principles...
Multiple Myeloma (MM) is an incurable plasma cell malignancy occurring within the bone marrow. Glucocorticoids (GCs) are widely used in the treatment of MM patients due to potent induction of apoptosis. Though known to occur via the glucocorticoid receptor (GR), the molecular details of GC-induced apoptosis in MM cells remain...
Prostate cancer (PCa) is the most commonly diagnosed cancer (1:6), and the second most common cause of cancer-related deaths in American men (>27,000/year). Metastasis is largely responsible for these deaths. During metastasis, tumor cells travel from the prostate to a distant organ where they establish a secondary tumor. Cell motility...
In this dissertation, I analyse the effectiveness of various political institutions in aggregating private information. In the first two chapters, I consider diversity of information among the voters about given electoral alternatives and examine the conditions under which plurality rule voting aggregates such information. In the third chapter, I consider...
Why would someone's judgments and choices disregard the consequences he or she cares about most? Considerable research appears to show that in many contexts, people show precisely this paradoxical tendency. Researchers interpret these results as showing that people sometimes make choices on the basis of moral factors -- factors that...
Alkenylsilanes of varying chain lengths are investigated as simultaneous chain transfer agents + comonomers in organotitanium-mediated olefin polymerization processes. Ethylene + alkenylsilane polymerizations were carried out with activated Me2Si(Me4C5)(NtBu)TiMe2 and (-CH2CH2-3,3'){(5-indenyl )[1-Me2Si(tBuN)]}2Ti2Me4 precatalysts. Alkenylsilane incorporation levels follow the trend C8H15SiH3 < C6H11SiH3 ≈ C4H7SiH3 < C3H5SiH3. Long-chain branching levels versus...
Structural dynamics in three polymer blend systems, differing largely with respect to morphology, have been investigated. The first system, composed of two immiscible homopolymers, exhibits a microstructure of micron-sized droplets dispersed in a matrix phase. We have examined small-angle x-ray scattering (SAXS) as a new approach for conducting in situ...
"Anosognosia" or lack of insight into one's own illness is not uncommon in central nervous system disease. Neurodegenerative diseases of the brain that cause dementia are often associated with anosognosia. A lot is known about anosognosia in Alzheimer's disease but relatively little is known about lack of insight into illness...
Chronic kidney disease (CKD) is the ninth leading cause of death in the United States. According to the National Kidney Foundation, more than 20 million people already have CKD, and another 20 million are at risk for developing CKD. The primary causes of kidney disease are diabetes followed closely by...
Barbed end regulation is critical to the formation of the actin-based protrusive structures, lamellipodia and filopodia. In this body of work we have chosen to focus on two main activities, filament termination by the heterodimeric Capping protein (CP) and continued filament elongation by the Ena/VASP family of proteins. We demonstrate...
Child psychology research has helped to identify how symptoms and deficits, or psychiatric needs impact the human experience, immediately and across development. Recent investigations indicate that strengths, both those possessed by the individual, and those present in her environment, exert short- and long-term protective influence that buffers the impact of...
Early growth response genes (Egr1-4) are induced as immediate early genes by a variety of extracellular stimuli that influence cellular growth and differentiation. Egr transcriptional regulators modulate gene expression by binding to Egr response elements (ERE) in target genes. In this study, the low affinity p75 neurotrophin receptor (p75NTR) was...
Graphene sheets (one-atom-thick, two-dimensional layers of sp2-bonded carbon) are predicted to have a range of unusual properties. Recent studies have shown that individual graphene sheets have extraordinary electrical properties, but an efficient method of graphite exfoliation remains a challenge. A number of approaches to exfoliation have been tried, such as...
There is a need for cyclic robots that interact with lower limbs. Such robots will bring new programmability to exercise, rehabilitation, psychophysiology, and physiology, allowing for complete customization of the foot pedal path and dynamics. These robots are novel to the robotics research ¯eld as well, since conventional robotic designs...
My study examines three participatory learning environments in which computer-based tools and improvisational training techniques comprise innovative approaches to teaching performance studies to undergraduate students. For my analysis, I have selected to focus on two classes and one production project. I contend that performance, an interdisciplinary and collaborative art form,...
In this work, the processing of the superconductor MgB<sub>2</sub> was studied to create a fundamental scientific background for the production of superconducting composite wires. The synthesis of MgB<sub>2</sub> from Mg and B powders was investigated in situ to determine reaction rates and kinetic parameters for the application of powder-in-tube technology...
Little is known about the transcriptional events underlying megakaryocytic (Mk) differentiation from hematopoietic stem cells. We sought to identify genes and pathways not previously associated with megakaryopoiesis and to evaluate the CHRF-288-11 (CHRF) megakaryoblastic cell line as a model system for investigating megakaryopoiesis.
Using DNA microarrays, Q-RT-PCR, and protein-level assays,...
Megakaryocytic cells (Mks) are derived from hematopoietic stem cells (HSCs) and give rise to platelets. Ex vivo culture of HSCs under conditions that promote Mk differentiation has been proposed as a method for producing Mks and platelets for cell therapies. Mk maturation involves the development of polyploid cells via endomitosis,...
In this dissertation I examine the relationship between voter turnout and legislative representation in the United States Congress. My main contention is that political elites react to electoral participation in formulating public policies. I posit that the institutional advantages of incumbency in the House of Representative reduces turnout in congressional...
This dissertation covers the synthesis and study of peptide nucleic acids (PNAs), specifically, derivatives of PNA containing amine-bearing sidechains or cyclopentane portions. PNAs are non-natural nucleic acids that have far reaching potential in therapeutics and nucleic acid detection. Despite immense potential and widespread application, improving on the design and applications...
This study investigates the causes and welfare consequences of unravelling in two-sided matching markets. "Unravelling" arises when agents contract with one another at an early stage, before much of the relevant information is available. Such early matches may lead to ex-post inefficiencies and are perceived as socially harmful. This study...
Gonadotropin releasing hormone (GnRH) neurons comprise the final pathway through which the central nervous system exerts its control over the hypothalamic-pituitary-gonadal (HPG) axis. GnRH is released in a pulsatile manner, and conveyed to the anterior pituitary gland to stimulate synthesis and secretion of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating...
Gradient copolymers are novel materials that possess a gradual variation in composition along the chain, thereby forming an intermediate structure between random and block copolymers. As such, they are a model system to investigate the effect of molecular structure on fundamental properties of copolymers and may be useful in many...
Gradient copolymers are novel materials that possess a gradual variation in composition along the chain, thereby forming an intermediate structure between random and block copolymers. As such, they are a model system to investigate the effect of molecular structure on fundamental properties of copolymers and may be useful in many...
Development of the central nervous system requires the coordinated interplay of intrinsic and extrinsic factors. I examined the actions of an extrinsic factor, TWEAK, and an intrinsic factor, Iroquois1 (Irx1) on neural progenitor cell behavior. Embryonic day 12 (E12) and post-natal day 1 (PN1) neural progenitor cells both express Fn14,...
Direct dynamics quasiclassical trajectory (QCT) calculations are performed to study the dynamics of model atom + polyatom reactions. In the first part of this thesis, we examine adiabatic dynamics of H/O reaction with simple alkanes, CD4 and C2H6. Overall good agreement with state-of-the-art experiments shows that the molecular motion is...
Age-related maculopathy (ARM) is a leading cause of legal blindness in the elderly in the world. Currently, the physiological and ultrastructural bases for the development of ARM remain unclear. Many studies have proposed that the morphological changes, particularly the accumulations of lipids with aging, in Bruch's membrane - an extracellular...
One of the current goals in the biomaterials research is to develop implants with improved osteoconductivity and long-term stability. Thanks to its chemical similarity to the mineral phase of natural bone, hydroxyapatite (HA) has been extensively studied and clinically tested as a coating on metallic substrates, to obtain bioactive implants...
Small molecule organic materials based on perylene- and naphthalene- diimide are synthesized and characterized for use as semiconductor thin films in organic field-effect transistors. The orbital energetics of the materials are investigated via electrochemical, spectroscopic, and computational techniques. The thin film solids are characterized by x-ray diffraction techniques and surface...
In this thesis, we study routing and resource allocation problems which have probabilistic objective functions. This class of problems has received limited attention in literature despite its promising applications. A probabilistic objective function is capable of incorporating business targets into the problem modeling and representing the risk attitude of a...
The nervous system develops through the highly regulated process of proliferation and differentiation of neural stem cells. Two major regulatory pathways that maintain neural stem cells in a proliferative state or promote their differentiation are the Notch and BMP signaling pathways, respectively. In this dissertation, we demonstrate that HeyL, a...
Living organisms grow precisely controlled assemblies of inorganic crystals using organic substrates. This observation has inspired the strategy of using synthetic organic templates for the growth of tailored inorganic thin films. It has been previously shown that monomolecular organic layers floating on supersaturated aqueous subphases (Langmuir monolayers) select the structure...
The self-assembly of quantum dots (QDs) in thin solid films is an important area of nanotechnology with many relevant applications. In the present thesis, three problems related to the growth and self-assembly of QDs are investigated.
In Chapter 1, a new instability mechanism for the formation of QDs associated with...
The present studies aimed at developing a lie detection paradigm immune to countermeasures, while the theoretical issues of top-down influence of task requirement on subliminal semantic priming were investigated. In Experiment 1, subjects were presented supraliminal acquaintance and non-acquaintance names, which were subliminally primed by another acquaintance or non-acquaintance names....
Because soft materials, particularly polymer gels, are playing a greater role in industrial and biotechnological applications today, the exploration of their mechanical behavior over a range of deformations is becoming more relevant in our daily lives. Understanding these properties is therefore necessary as a means to predict their response for...
Activin, a member of the TGF-b superfamily, controls a variety of physiological events from the cell cycle to reproductive health. Activin activates the Smad signaling pathway through ActRII/B and ALK4 receptors. The regulation of activin signaling is carried out in part by the inhibitor protein follistatin. The mechanistic details of...
Weak optical signals, e.g., Raman scattering, fluorescence emission, etc., are typically enhanced by increasing both the excitation field and the collection efficiency. Near a surface, signals can be resonantly enhanced using either surface plasmon polaritons or a resonant dielectric waveguide, provided the sources lie within an evanescent decay length of...
Constructing 3D objects from 2D images has been an active research area for decades. Given captured 2D information from various devices, different techniques were developed to assign 3D positions to the target object. However, methods for reconstructing a 3D model from a single 2D image remain largely manual and labor-intensive....
Cluster Analysis deals with classifying a sample of multivariate measurements into different categories. In this dissertation we study the effect of the correlation structure of the data on the performance of a clustering method. We begin with the analysis of two-component normal mixture models and then proceed to cluster analysis...
Metal oxide surfaces are generally recognized as active substrates for many catalytic reactions. Density Functional Theory (DFT) has been found as a useful computational tool to investigate the geometry, energy, electronic structure of reactive oxide surfaces and their interaction with small molecules and fragments. In this thesis, primary efforts have...
This dissertation develops dynamic models to examine markets with product differentiation where both firm conduct and consumer behavior is jointly influenced by switching costs, network effects and technological innovation. In Chapter 1 I propose a structural model of competition where firms set prices, introduce new products and scrap obsolete models....
Okilactomycin and chrolactomycin are antitumor antibiotics isolated in 1987 and 2001, respectively. These tetracyclic natural products possess a unique 6-5 fused tetrahydropyrone-butyrolactone. The spirocenter is part of a highly functionalized cyclohexene ring, which together with the aforementioned 6-5 system compose the core of these molecules. A six carbon, 1,3-dialkyl-substituted carbon...
This study investigates the nature of the face-to-face interactions and collaborations between secondary school students and community members in the nested contexts of the classroom and a local Italian community, both situated in a large city in Canada. Students used the tools of inquiry of cultural ethnographers, interviewing members of...
In this dissertation, the Tg behavior of nanoconfined polymer films and 1-dimensional (1-D) patterned polymer nanostructures was studied. Using a novel fluorescence method, a reduction in Tg was observed upon confinement in PS films supported on silica, where free-surface (polymer-air interface) effects are dominant in modifying Tg. In contrast, Tg...
My dissertation investigates the social mechanisms that determine the allocation of consequences of earnings restatements for organizational elites, using a sample S&P1500 Index-listed firms restating earnings between 1997 and 2003. In chapter 1, I examine turnover following revelations of organizational misconduct. I find that outside director turnover is associated with...
Surfaces and interfaces, which are ubiquitous in the environment, control the mobility,speciation, and ultimate fate of groundwater species. The presented work provides insight into the interfacial behavior of three environmental pollutants: hexavalent chromium, oxytetracycline, and morantel. Model surfaces are employed for these studies, including (1-102) α-Al<sub>2</sub>O<sub>3</sub> and a carboxylic acid-terminated...
This dissertation examines and seeks to revitalize the concept of "distraction," through an analysis of the changes it underwent in German-speaking philosophy, critical theory, and literature between the World Wars. Defying the sociological and psychological norms of the period, Franz Kafka, Martin Heidegger, and Walter Benjamin refused to treat distraction...
This dissertation describes the invention and development of a new nanolithographic method: On-Wire Lithography (OWL). OWL is a simple, reproducible, and high-throughput procedure for the synthesis and lithographic processing of metal nanowires (i.e. Au, Ag, Pt, Ni, and Cu) that allows researchers to control the morphology and feature size of...
The overarching theme of this thesis is the development of non-natural oligomers for use in biological applications. Chapter I details the synthesis and studies of modified peptide nucleic acid (PNA) oligomers. PNA is a synthetic oligonucleotide mimic that binds to natural nucleic acids with extremely high affinity and specificity, making...
The physics of granular materials is one of the big questions in science. Granular materials serve as a prototype of collective systems far from equilibrium and fundamental questions remain. At the same time, an understanding of granular materials has tremendous practical importance. Among practical problems, granular mixing and its interplay...
This dissertation examines the development of a black theater aesthetic in Jamaica as the colony prepared for independence. I define my theory of myalisation to explain how middle class theatre audiences participated in the Afro-Jamaican religious rituals of the lower class and how their participation signaled the development of a...
In chapter 1, we study the investment behavior of firms faced with uncertainty, irreversibility and non-convex adjustment costs when output can be stored. A discrete-time dynamic optimization problem is solved numerically using neural networks to study the investment problem. Our numerical results suggest that whether or not firms can store...
Encouraging honest behavior and discouraging deceptive behavior has become a very important issue with respect to ethics and moral behavior in the workplace. As such, a critical practical and theoretical goal has been to directly study the likelihood of individuals punishing deception and rewarding honesty. The growing assumption within the...
Angiogenesis, the formation of blood vessels from a pre-existing vasculature, is a process whereby capillary sprouts are formed in response to chemical stimuli that can be either supplied externally or produced locally.
Understanding of the fundamental mechanisms that govern angiogenesis suggests a powerful therapeutic approach that will allow to combat...
In the Old Northwest, networks of activists across dispersed communities took controversial direct action against prejudice and slavery. By largely eschewing the growing cities that disproved the Old Northwest rule, this is a study of reform as it would have impacted most people, at the local level in the smaller...
This thesis contains four essays on the organization (both internal and external) of health care in the US. The first essay examines a mechanism through which individual workers acquire (or maintain) competence, namely that of experience. Specifically, I analyze whether cardiac surgeons who perform more procedures experience an improvement in...
Nelson and Staum derived ranking-and-selection procedures that employ control-variate (CV) estimators instead of sample means to obtain greater statistical efficiency. However, control-variate estimators require more computational effort than sample means, and effective controls must be identified. In this dissertation, we present a new CV screening procedure to avoid much of...
This work investigates children's early semantic representations of gradable adjectives (GAs) and proposes that infants perform a probabilistic analysis of the input to learn about abstract differences within this category. I first demonstrate that children as young as age three distinguish between relative (e.g., 'big', 'long'), maximum standard absolute (e.g.,...